ANCA in Systemic Vasculitides, Collagen Vascular Diseases, Rheumatic Disorders and Inflammatory Bowel Diseases

Hauschild, S.; Schmitt, Wilhelm H.; Csernok, Elena; Flesch, Brigitte K.; Rautmann, A; Gross, Wolfgang L.

doi:10.1007/978-1-4757-9182-2_36

Cited by 66 publications

(73 citation statements)

References 9 publications

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“…Skogh & Peen [9] even detected ANCA against lactoferrin in 50% of UC sera irrespective of the ANCA status in immunofluorescence. This, however, could not be confirmed by our group [6]. By contrast, ANCA against lactoferrin have been reported in higher frequencies in a variety of inflammatory disorders, including systemic lupus erythematosus [24] and vasculitis [6].…”

Section: Discussioncontrasting

confidence: 62%

“…This, however, could not be confirmed by our group [6]. By contrast, ANCA against lactoferrin have been reported in higher frequencies in a variety of inflammatory disorders, including systemic lupus erythematosus [24] and vasculitis [6].…”

Section: Discussioncontrasting

confidence: 62%

“…ANCA rates oscillating between 49% and 88% in UC and 10% and 40% in CD were reported by separate authors [21,22]. Two other groups [8,23] found ANCA to be directed against cathepsin G, but this could be confirmed by neither Duerr et al [20] nor by us [6]. Furthermore, Duerr et al [20] reported that ANCA in IBD are not directed against PR3, MPO, or elastase.…”

Section: Discussionmentioning

confidence: 90%

“…Cathepsin G [8], lactoferrin [9], lysozyme [10], and other as yet undefined proteins have been described as candidate autoantigens. However, these antigens were found in only a minor portion (<20%) of patients with IBD, and in a similarly low percentage of patients with vasculitis [6].…”

Section: Introductionmentioning

confidence: 93%

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Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders

Stoffel

Csernok

Herzberg

et al. 1996

Clinical and Experimental Immunology

109

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SUMMARYIt was our purpose to determine the immunodiagnostic value of ANCA directed against BPI in diseases known to be associated with ANCA, such as ANCA-associated vasculitides, inflammatory bowel disease (IBD) and the associated condition primary sclerosing cholangitis. The immunoreactivity of recombinant BPI (rBPI) was established in order to develop an ELISA specific for rBPI. By means of this assay, BPI-ANCA were assessed in sera of 178 patients with IBD or the associated disorder primary sclerosing cholangitis, 112 patients with ANCA-associated vasculitides, and in sera of 182 disease and 140 healthy controls. BPI-ANCA were found to be closely associated with IBD and primary sclerosing cholangitis (34% and 44% of ANCA-positive sera, respectively). By contrast, BPI-ANCA positivity was low (<10%) in the double-negative sera of patients with ANCA-associated vasculitides and in disease and healthy controls. BPI-ANCA appear to constitute an important marker for IBD and primary sclerosing cholangitis, but not for the ANCA-associated vasculitides.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders

Stoffel

Csernok

Herzberg

et al. 1996

Clinical and Experimental Immunology

109

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“…In addition, the group studied by Falk et a1 (12) was very heterogeneous: among 37 WG patients, only 19 were positive for cANCA (compared with all 43 patients in our study). Classic ANCA is a highly specific diagnostic indicator of WG, lacking in <lo% of patients with active generalized disease (6,13). The high incidence of perinuclear-pattern ANCA (pANCA) positivity observed in Falk's patients is unusual in WG.…”

Section: Discussionmentioning

confidence: 99%

Influence of disease manifestation and antineutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with wegener's granulomatosis

Reinhold‐Keller

Kekow

Schnabel

et al. 1994

Arthritis & Rheumatism

Self Cite

166

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Objective. To assess the effectiveness of pulse cyclophosphamide (CYC) in the treatment of Wegener's granulomatosis (WG) and to identify the patients who are responsive to the treatment.Methods. The prospective study included 43 patients with biopsy-proven WG. Clinical, radiographic, laboratory, and immunologic data were evaluated for predicitive values regarding the outcome of pulse CYC therapy.Results. Only 42% of the patients showed complete or partial remission that lasted at least 6 months after cessation of pulse CYC therapy. These responders had a higher frequency of disease activity limited to the upper and lower respiratory tract (39%, versus 8% in the nonresponder group; P < 0.05) and had lower titers of classic antineutrophil cytoplasmic antibody (cANCA) prior to treatment (<1:64 42%, versus 6% in the nonresponder group; P < 0.05). In the 58% of patients who did not respond to pulse CYC treatment, there was both systemic disease involving more than 4 organ systems (mainly, the heart, nervous system, eye, and

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Standardized Neurologic Evaluations of 128 Patients With Wegener Granulomatosis

Groot¹,

Schmidt²,

Arlt³

et al. 2001

Arch Neurol

Self Cite

197

109

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Peripheral neuropathy is frequent in generalized WG, occurring early in the disease course. As PN can be the first and sole symptom of a beginning systemic vasculitis, it is important that in cases of PN of an unclear origin, interdisciplinary investigations are initiated to detect, treat, and closely follow-up a possible underlying WG, especially as these patients seem to have a more severe disease course.

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ANCA in Systemic Vasculitides, Collagen Vascular Diseases, Rheumatic Disorders and Inflammatory Bowel Diseases

Cited by 66 publications

References 9 publications

Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders

Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders

Influence of disease manifestation and antineutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with wegener's granulomatosis

Standardized Neurologic Evaluations of 128 Patients With Wegener Granulomatosis

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