ANCA in diseases other than systemic vasculitis

Peter, Hans; Metzger, Dennis W.; Rump, Amy; Röther, E

doi:10.1111/j.1365-2249.1993.tb06217.x

Cited by 25 publications

(5 citation statements)

References 25 publications

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“… 3 Fluorescent patterns that are neither cytoplasmic nor perinuclear are termed ‘atypical’ and are found in conditions such as rheumatoid arthritis and inflammatory bowel disease. 4 Our patient had an atypical P-ANCA which was anti-PR3 and anti-MPO negative. Although not the usual pattern in Wegener's granulomatosis, it is reported in approximately 10% of cases.…”

Section: Discussionmentioning

confidence: 63%

Wegener's granulomatosis with multiple pulmonary nodules – diagnostic difficulties

et al. 2010

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Section: Discussionmentioning

confidence: 63%

Wegener's granulomatosis with multiple pulmonary nodules – diagnostic difficulties

et al. 2010

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“…The pathogenic role of these target antigens in vasculitis remains to be elucidated, but they may play a certain role as markers of certain inflammatory and infectious conditions such as IBD, SLE, RA and subacute bacterial endocarditis (SBE). [10][11][12][13][14]. The notion that ANCA might be of clinical, diagnostic and pathologic relevance in these various clinical settings was the driving force behind the preparation of the 2020 consensus statement on ANCA testing beyond systemic vasculitis, which recommended the testing of specific ANCA targeting proteinase-3 and myeloperoxidase by solid phase immunoassays in patients with anti-GBM disease, idiopathic interstitial pneumonia and infective endocarditis with nephritis [15].…”

Section: Discussionmentioning

confidence: 99%

Clinical implications of ANCA positivity in a hospital setting: a tertiary center experience

et al. 2020

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ANCA testing plays an established critical role in the diagnosis of ANCA Associated vasculitis (AAV). The spectrum of diseases associated with positive ANCA has recently broadened, thus calling into question the diagnostic implications of ANCA positivity in a hospital setting. We retrospectively studied all adult patients who had a positive ANCA test (by Indirect Immunofluorescence (IIF), ELISA or both) performed over the span of 19 years. Subjects were then divided into discordant (positive on one assay) and concordant ANCA (positive on both assays) groups based on their ANCA positivity status. The two groups were then compared with regards to their demographic, clinical and laboratory characteristics, the indication for ANCA testing in both groups and their final diagnoses. Of the 9189 ANCA tests ordered during the 19-year span of the study, 389 (4.2%) were positive. Two hundred and forty subjects met the exclusion criteria (patients aged less than 18 years or the lack of clinical and laboratory data in the medical file) thus resulting in a final cohort of 149 subjects. Of them, 122 subjects had discrepant ANCA results and 27 had matching ANCA results. Most cases in the discrepancy group were IIF positive and ELISA negative (86.8%). The diagnosis of AAV was highly unlikely in cases with discrepant IIF and ELISA serologies compared to cases with matching IIF and ELISA serologies (4.1% versus 44.4%, p value < 0.001). The diagnosis of AAV in unlikely in subjects with discrepancies between IIF and ELISA, particularly with only positive IIF.

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“…Also, the ANCA that have been detected in RA bind to neutrophil components other than PR3 and MPO. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

ANCA-associated Goodpasture′s syndrome in a patient with rheumatoid arthritis on penicillamine

2012

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Although penicillamine has been used effectively in the management of a variety of diseases, several adverse reactions have been observed with prolonged administration of this agent. We report a case of Goodpasture's syndrome, as a result of induction of anti-myeloperoxidase antineutrophil cytoplasmic antibodies in a 51 year old man who was being treated with this drug for rheumatoid arthritis. This pulmonary-renal syndrome has been described on rare occasions in patients receiving penicillamine. Treatment with steroids and cyclophosphamide resulted in pulmonary and renal functional recovery.

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ANCA in diseases other than systemic vasculitis

Cited by 25 publications

References 25 publications

Wegener's granulomatosis with multiple pulmonary nodules – diagnostic difficulties

Wegener's granulomatosis with multiple pulmonary nodules – diagnostic difficulties

Clinical implications of ANCA positivity in a hospital setting: a tertiary center experience

ANCA-associated Goodpasture′s syndrome in a patient with rheumatoid arthritis on penicillamine

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