ANCA-associated vasculitis in patients with primary Sjögren's syndrome: Detailed analysis of 7 new cases and systematic literature review

“…The SS, SLE, and RA are all the autoimmune diseases with a higher incidence rate and often involve in the connective tissues of the skin, mucous membrane, glands, and so forth [4–8]. Hence, the cornea, conjunctiva, and lacrimal gland tissues of the ocular surface have also become the immune attack positions, which lead to the damage of their structures and functions and cause the severe ocular surface problem, for example, dry eye.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Clinical Characteristics of Immune-Related Dry Eye

Wang

Chen

et al. 2017

Journal of Ophthalmology

View full text Add to dashboard Cite

Aim To discuss the clinical characteristics of immune-related dry eye. Methods Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren's syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA). The classification of all patients was performed. The difference between the two groups was compared, including age, gender, ocular surface fluorescein staining and inflammatory reaction, tear breakup time (TBUT), Shirmer I test, confocal microscopy scan, and dry eye grading. Results Compared with the SDE group, the patients of IRDE group were younger (P < 0.05). The female patients were significantly more than the male ones (P < 0.05). Corneal staining counts and ocular surface inflammation were significantly increased (P < 0.05). TBUT and Shirmer I test shortened significantly (P < 0.05). Corneal nerve fibers were less, and the number of local lymphocyte was significant increased. The number of dry eye patients in the moderate or above IRDE group was significantly increased (P < 0.05). Conclusions The dry eye symptom and sign and ocular surface inflammation of IRDE were significantly more severe than those of the SDE.

show abstract

“…Lionaki et al conducted a case–control study of 158 cases of AAV, and found a history of thyroid disease to be more common in cases than in age- and sex-matched controls (OR = 3.7, 95% CI: 1.5, 9.2; P = 0.005) [ 30 ]. Other evidence comes from case series: there have been reports of 6 cases where AAV occurred after a diagnosis of RA [ 31 ], 7 cases of co-existence of primary SS and AAV [ 32 ] and 35 cases of co-existence of scleroderma and AAV [ 33 ]. It seems likely that the finding of clustering of autoimmune diseases in individuals [ 29 ] is contributed to by shared genetic susceptibility loci at immune regulatory genes (HLA [ 34 ], CTLA-4 [ 35 , 36 ], PTPN22 [ 37 ] and CD40 [ 38 ]) [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink

et al. 2018

View full text Add to dashboard Cite

ObjectivesWe aimed to provide insights into the aetiology of granulomatosis with polyangiitis (GPA), by conducting a large case–control study using a general population-based, prospectively collected database of healthcare records.MethodsWe compared all incident cases of GPA in the Clinical Practice Research Datalink 1990–2014, with up to 10 age-, sex- and general practice-matched controls. We identified potential risk factors, recorded numbers of cases and controls exposed to each, and calculated odds ratios (ORs) using conditional logistic regression. Our main analysis excluded data recorded during 1 year before diagnosis, to prevent early symptoms being mistaken for risk factors.ResultsWe identified 757 people with GPA and matched 7546 controls. People with GPA were five times more likely to have a previous diagnosis of bronchiectasis (OR = 5.1, 95% CI: 2.7, 9.4; P < 0.0001), and these effects remained stable in diagnoses recorded >5 years prior to diagnosis. People with GPA were two to three times more likely than controls to have previous diagnoses of autoimmune diseases or chronic renal impairment, and these effects also remained stable >5 years prior to diagnosis. People with GPA were more likely to have a diagnosis of pulmonary fibrosis (OR = 5.7, 95% CI: 1.7, 19.5; P = 0.01) and sinus infections (OR = 2.7, 95% CI: 1.8, 4.2; P < 0.0001) recorded in the 3 years before diagnosis, but not before this. We also found former smoking, some medications and higher socio-economic status significantly, but less strongly, associated.ConclusionWe found novel long-term associations between GPA and pre-existing bronchiectasis and autoimmune diseases.

show abstract

ANCA-associated vasculitis in patients with primary Sjögren's syndrome: Detailed analysis of 7 new cases and systematic literature review

Cited by 53 publications

References 35 publications

Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis

Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis

Analysis of Clinical Characteristics of Immune-Related Dry Eye

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink

Contact Info

Product

Resources

About