ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine

Abstract

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Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination

“…Prior cases have been mainly reported among elderly individuals without known renal diseases. Six cases have been associated with a mRNA vaccine, while a viral vector vaccine has been associated with two cases (8)(9)(10)(11)(12)(13)(14). AAV was diagnosed after either the first dose (37.5%) or second dose (62.5%) of COVID-19 vaccination.…”

“…AAV was diagnosed after either the first dose (37.5%) or second dose (62.5%) of COVID-19 vaccination. The onset time of symptoms varied from <1 week to 7 weeks (8)(9)(10)(11)(12)(13)(14). While non-specific prodromal symptoms were observed after vaccination, characteristic findings included microscopic or gross hematuria with dysmorphic red blood cells, significant proteinuria, and acute renal failure (8)(9)(10)(11)(12)(13)(14).…”

“…The onset time of symptoms varied from <1 week to 7 weeks (8)(9)(10)(11)(12)(13)(14). While non-specific prodromal symptoms were observed after vaccination, characteristic findings included microscopic or gross hematuria with dysmorphic red blood cells, significant proteinuria, and acute renal failure (8)(9)(10)(11)(12)(13)(14). Serum creatinine levels ranged from 1.9 to 8.4 mg/dL (8,(10)(11)(12)(13)(14).…”

Case Report: ANCA-Associated Vasculitis Presenting With Rhabdomyolysis and Pauci-Immune Crescentic Glomerulonephritis After Pfizer-BioNTech COVID-19 mRNA Vaccination

“…Generally, renal manifestations in AAV are estimated at 80% among all cases mainly manifesting as ANCA-associated glomerulonephritis (ANCA GN), and the overall prevalence does not seem to differ substantially between MPO-ANCA and PR3-ANCA AAV (6). Interestingly, five cases of renal AAV presenting with pauci-immune crescentic ANCA GN after COVID-19 mRNA vaccination have already been reported (7)(8)(9)(10). We here expand our current knowledge of this rare but important association and report a case of AAV presenting with massive rhabdomyolysis and pauci-immune crescentic GN after Pfizer-BioNTech COVID-19 mRNA vaccination.…”

Cutaneous Leukocytoclastic Vasculitis Induction Following ChAdOx1 nCoV-19 Vaccine

“…An international registry of 414 cutaneous reactions following Pfizer-BioNTech, and Moderna vaccines reported three vasculitides [5]. LCV is a rare vaccine side effect; however, recent case reports presented the flare of LCV, antineutrophil cytoplasmic antibody vasculitis, and varicella-zoster-related vasculitis following Pfizer-BioNTech vaccine [7][8][9] and cutaneous vasculitis following inactivated whole virion vaccine [10]. To the best of our knowledge, no LCV case following the ChAdOx1 nCoV-19 vaccine has been reported so far.…”