ANCA-associated vasculitis as paraneoplastic syndrome with colon cancer: a                 case report

Díez-Porres, Leyre; Ríos-Blanco, Juan José; Robles‐Marhuenda, Ángel; Gutiérrez-Molina, M; Gil‐Aguado, Antonio; Vázquez-Rodríguez, Juan José

doi:10.1191/0961203305lu2153cr

Cited by 32 publications

(30 citation statements)

References 7 publications

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“…The association of ANCA-associated vasculitis with solid tumors has been sporadically reported 22, 23, 25–28. These reports demonstrate that ANCA-associated vasculitis can occur concurrently with cancer, but cancers are frequently diagnosed after the vasculitis.…”

Section: Solid Tumorsmentioning

confidence: 87%

Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

2010

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Paraneoplastic glomerulonephritis is a rare complication of malignancy that is frequently mistaken for idiopathic glomerulonephritis. Failure to recognize paraneoplastic glomerulonephritis can subject patients to ineffective and potentially harmful therapy. Pathology of paraneoplastic glomerulonephritis varies between different types of malignancies. This Review describes the association of glomerulonephritis with both solid tumors and hematological malignancies The pathogenetic mechanisms of many glomerular lesions seem to relate to altered immune responses in the presence of a malignancy Studies in the Buffalo/Mna rat model of spontaneous thymoma and nephrotic syndrome indicate that polarization of the immune response toward a T-helper-2 (T H 2) profile has an important role in the development of thymoma-associated glomerular lesions. Furthermore, overexpression of the T H 2 cytokine interleukin 13 in transgenic rats induces minimal change disease. Such findings from experimental studies might facilitate the identification of biomarkers that can distinguish paraneoplastic glomerulonephritis from idiopathic and other secondary glomerulonephritides. This Review describes potential pathogenetic mechanisms for paraneoplastic glomerulonephritides associated with different malignancies and highlights the need for a multidisciplinary approach to the management of patients with paraneoplastic glomerulonephritis.

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Section: Solid Tumorsmentioning

confidence: 87%

Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

2010

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“…A subsequent literature search failed to identify other reports of an association between gastric cancer and AAV. However, AAV has been reported to respond to resection of colon cancer and steroid treatment [5], suggesting that cancer causes or exacerbates AAV in some patients [3,6]. Generally, ANCA-associated nephritis is characterized by glomerular and vascular damage, and the presence of only tubulointerstitial lesions is extremely rare [7], although it has been reported [8].…”

Section: Discussionmentioning

confidence: 97%

Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

Hosoya¹,

Minota²,

Lefor³

et al. 2009

Mod Rheumatol

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We report a case of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis in a 62-year-old patient with gastric cancer. The myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) level was threefold above normal preoperatively. Vasculitis was seen on renal biopsy. Gastric resection revealed well-differentiated adenocarcinoma and vasculitis. The MPO-ANCA level returned to normal post-operatively. Although ANCA-associated vasculitis occasionally accompanies malignant tumors, this is the first documented case of concurrent gastric cancer-associated and ANCA-associated vasculitis, with post-operative resolution of the vasculitis.

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“…[13] Another case report described an unusual association of P-ANCA-positive vasculitis in a patient suffering from colon cancer in whom the vasculitis resulted in impressive neurological symptoms. [14] The recognition of PVN is important as these syndromes may respond to primary tumor removal and immunosuppression using corticosteroids along with cyclophosphamide. [14] The response to treatment may either be complete or partial.…”

Section: Discussionmentioning

confidence: 99%

“…[14] The recognition of PVN is important as these syndromes may respond to primary tumor removal and immunosuppression using corticosteroids along with cyclophosphamide. [14] The response to treatment may either be complete or partial. In our cases also, the patients improved partially after treatment with corticosteroids and cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%