ANCA-associated vasculitis

Yates, Max; Watts, Richard A.

doi:10.7861/clinmedicine.17-1-60

Cited by 169 publications

(170 citation statements)

References 21 publications

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“…The pathogenesis of AAV involves the interplay of many cell types of the immune system, including neutrophils, monocytes and B cells, all of which contribute to T cell differentiation and activation and controlled by cytokines released by T cells [2][3][4][21][22][23]. CD4 1 T cells produce Th1 and Th17 cytokines, such as interferon (IFN)-g and interleukin (IL)-17, respectively, are expanded in the circulation of patients with GPA and MPA [24,25], whereas Th2 cells, producing IL-4, IL-5 and IL-13, are more frequent in patients with EGPA [24,[26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

Fazekas

Moreno‐Olivera

Kelly

et al. 2017

Clinical and Experimental Immunology

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Innate lymphocyte populations, such as innate lymphoid cells (ILCs), γδ T cells, invariant natural killer T (iNK T) cells and mucosal-associated invariant T (MAIT) cells are emerging as important effectors of innate immunity and are involved in various inflammatory and autoimmune diseases. The aim of this study was to assess the frequencies and absolute numbers of innate lymphocytes as well as conventional lymphocytes and monocytes in peripheral blood from a cohort of anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV) patients. Thirty-eight AAV patients and 24 healthy and disease controls were included in the study. Patients with AAV were sampled both with and without immunosuppressive treatment, and in the setting of both active disease and remission. The frequencies of MAIT and ILC2 cells were significantly lower in patients with AAV and in the disease control group compared to healthy controls. These reductions in the AAV patients remained during remission. B cell count and frequencies were significantly lower in AAV in remission compared to patients with active disease and disease controls. Despite the strong T helper type 2 (Th) preponderance of eosinophilic granulomatosis with polyangiitis, we did not observe increased ILC2 frequency in this cohort of patients. The frequencies of other cell types were similar in all groups studied. Reductions in circulating ILC2 and MAIT cells reported previously in patients with AAV are not specific for AAV, but are more likely to be due to non-specific manifestations of renal impairment and chronic illness. Reduction in B cell numbers in AAV patients experiencing remission is probably therapy-related.

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Section: Discussionmentioning

confidence: 99%

Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

Fazekas

Moreno‐Olivera

Kelly

et al. 2017

Clinical and Experimental Immunology

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“…GPA has a wide spectrum of clinical manifestations, including symptoms from the upper and lower respiratory system (hearing loss, epistaxis, inflammation, etc), cardiovascular symptoms (vasculitis, occlusive vascular disease, pericarditis, cardiomyopathy, ischemic heart disease, etc), gastrointestinal symptoms (mesenteric vasculitis, peritonitis), cutaneous and mucocutaneous symptoms. Renal participation may even lead to end‐stage renal failure …”

Section: Introductionmentioning

confidence: 99%

“…Renal participation may even lead to end-stage renal failure. 6,7 Involvement of the nervous system, even as the initial manifestation, is not uncommon, with reported frequencies ranging from 22 to 54% of patients. In older studies, peripheral nervous system (PNS) involvement seemed to dominate, predominantly as polyneuropathy or mononeuritis multiplex due to vasculitis of the vasa nervorum, whereas lesions of the central nervous system (CNS) were considered rather rare, with reported frequencies ranging from 7 to 11% (modern authors exclude cranial nerve palsies from CNS manifestations).…”

Section: Introductionmentioning

confidence: 99%

Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature

et al. 2018

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“…AAV is common in older adults, and slightly more common in men. 2 The ANCA-positive rate is much higher in patients with T1DM than in healthy individuals. 3 The database searches (PubMed, J-STAGE, and Ichushi) using the key words "type 1 diabetes mellitus" and "ANCA-associated vasculitis" identified just 10 T1DM cases of ANCA-associated vasculitis ( Table 1; File S1).…”

mentioning

confidence: 98%

Oldest‐old type 1 diabetes patient receiving insulin pump treatment with positive myeloperoxidase‐antineutrophil cytoplasmic antibody complication: A case report

Omura

Tamura

Kodera

et al. 2019

Geriatrics Gerontology Int

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DJ. Exercise-induced rhabdomyolysis mechanisms and prevention: a literature review. J Sport Health Sci 2016; 5: 324-333. 3 Wongrakpanich S, Kallis C, Prasad P, Rangaswami J, Rosenzweig A. The study of rhabdomyolysis in the elderly: an epidemiological study and single center experience. Aging Dis 2018; 9: 1-7. 4 Sahin OZ, Ayaz T, Yuce S, Sumer F, Sahin SB. A rare case of acute renal failure secondary to rhabdomyolysis probably induced by donepezil. Case Rep Nephrol 2014; 2014: 214359. 5 Keltz E, Khan FY, Rhabdomyolysis MG. The role of diagnostic and prognostic factors. Muscles Ligaments Tendons J 2013; 3: 303-312. 6 Maust DT, Kim HM, Seyfried LS et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiat 2015; 72: 438-445. 7 Rabinowitz J, Katz IR, De Deyn PP, Brodaty H, Greenspan A, Davidson M. Behavioral and psychological symptoms in patients with dementia as a target for pharmacotherapy with risperidone. J Clin Psychiatry 2004; 65: 1329-1334. 8 Kurz A, Schwalen SS, Schmitt A. Effects of risperidone on behavioral and psychological symptoms associated with dementia in clinical practice. Int Psychogeriatr 2005; 17: 605-616. 9 Hodgkinson B, Koch S, Nay R, Lewis M. Managing the wandering behaviour of people living in a residential aged care facility. Int J Evid Based Healthc 2007; 5: 406-436.

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ANCA-associated vasculitis

Cited by 169 publications

References 21 publications

Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature

Oldest‐old type 1 diabetes patient receiving insulin pump treatment with positive myeloperoxidase‐antineutrophil cytoplasmic antibody complication: A case report

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