Anatomy of the stomach

Mahadevan, Vishy

doi:10.1016/j.mpsur.2014.09.009

Cited by 14 publications

(18 citation statements)

References 1 publication

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“…The stomach is a hollow, distensible organ located in the left upper quadrant of the peritoneal cavity (Mahadevan, 2014). As a result of the distinct curving of the gastric wall, which is more pronounced on the left compared to the right border (i.e.…”

Section: Anatomymentioning

confidence: 99%

“…Branches of the celiac artery ensure adequate blood supply and drainage of blood to the stomach and venous blood drains into the portal system (Ellis, 2011;Mahadevan, 2014;Trowers and Tischler, 2014a). Similarly, lymphatic fluid is drained from lymph nodes distributed across the stomach and collected in the celiac lymph nodes (Farre and Tack, 2013;Mahadevan, 2014;Soybel, 2005;Trowers and Tischler, 2014a). The stomach is characterized by extensive intrinsic innervation.…”

Section: Blood Supply Lymphatic Flow and Innervationmentioning

confidence: 99%

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The dynamic gastric environment and its impact on drug and formulation behaviour

Abeele

Rubbens

Brouwers

et al. 2017

European Journal of Pharmaceutical Sciences

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Section: Anatomymentioning

confidence: 99%

Section: Blood Supply Lymphatic Flow and Innervationmentioning

confidence: 99%

The dynamic gastric environment and its impact on drug and formulation behaviour

Abeele

Rubbens

Brouwers

et al. 2017

European Journal of Pharmaceutical Sciences

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“…Although several anatomical regions in the stomach have since long been identified [4,5], these are seldom recognized in drug development. When evaluating drugs and formulations, the stomach is often considered to be a simple, one-compartmental organ in which a drug awaits transfer to the duodenum relatively undisturbed.…”

Section: Introductionmentioning

confidence: 99%

Exploring the link between gastric motility and intragastric drug distribution in man

Abeele

Brouwers

Tack

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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In drug development, the stomach is often considered to be a simple, one-compartmental organ, a waiting room for transfer of an orally administered dosage form to the duodenum. However, factors such as gastric acidity and hydrodynamics in the gastric environment may influence drug disposition. Although a link between gastrointestinal drug behaviour and gastric motility has often been hypothesized, they have not been simultaneously investigated in humans yet. In this proof-of-concept study, the combination of a well-established intraluminal sampling technique with high-resolution manometric measurements in the gastrointestinal tract was evaluated. This new combination of in vivo techniques proved to be feasible from a practical point of view and yielded valuable additional information regarding intraluminal drug behaviour. As a first application, the link between fasted state gastric motility and (in)homogeneous distribution of an orally administered drug in the stomach was investigated in healthy subjects. To this end, drug concentrations were measured in different regions of the stomach after oral administration of a commercially available drug product (Gabbroral®, 250mg paromomycin) during a specific period of gastric contractile activity. A clear trend towards better mixing of an orally administered drug with gastric contents was observed when dosed in the presence of gastric contractions, resulting in a more homogeneous distribution of the drug throughout the stomach compared to dosing in the absence of gastric contractions.

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“…When disaggregating rates by age category, the CI5X and CI5XI datasets combined gastric cancers of the lesser and greater curvature (C16.5 and C16.6) with those classified as ‘overlapping lesion of stomach’ and ‘stomach, not otherwise specified’ (C16.8 and C16.9). Because C16.5-6 are typically classified as cancers of the non-cardia gastric region [19,32,33], and because other analysts have reclassified all or some C16.8-9 cases as NCGC when these classifications are relatively common [2,34,35,36], we chose to attribute all cases classified as C16.5-9 to NCGC. It is possible that some of the cases classified as overlapping or unknown topography (C16.8-9) are, in fact, cancers of the cardia and were misclassified here; however, given the low proportion of cases classified as CGC in global populations, the degree of any potential misclassification is likely small.…”

Section: Discussionmentioning

confidence: 99%

“…In the CI5 and NT datasets, gastric cancer cases were classified according to the International Classification of Diseases, 10th Revision (ICD-10): Gastric cancer (C16), CGC (C16.0), and NCGC (C16.1-9). NCGC typically includes the following anatomical regions of the stomach: fundus, body, antrum, pylorus, lesser curvature, and greater curvature (C16.1-6) [19,32,33]. However, the CI5X datasets group cancers of the greater and lesser curvature (C16.5 and C16.6) with cancers classified as overlapping and not-otherwise specified (C16.8 and C16.9).…”

Section: Methodsmentioning

confidence: 99%

Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites

Colquhoun

Hannah

Corriveau

et al. 2019

Cancers

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In northern Canada where there is a high prevalence of Helicobacter pylori infection, there is a paucity of information on gastric cancer by the topographical subsites cardia (CGC) and non-cardia (NCGC). Here we describe the incidence of CGC and NCGC, separately, among northern Canadian populations. We used data from the Cancer Incidence in Five Continents Volumes X (CI5X) and XI (CI5XI) to obtain CGC and NCGC incidence for Canada and for Yukon (YT), a northern Canadian territory. Using these data with those provided by the Government of the Northwest Territories (NT), we estimated standardized incidence ratios comparing northern populations to Canada as a whole. We also estimated age-standardized incidence rates to permit comparisons across populations globally. NT and YT populations were disproportionately impacted by gastric cancer, particularly NCGC. This was especially true for Indigenous populations: NCGC incidence rates among NT Indigenous men were 2.7 times the rates among all men in Canada, while rates among NT Indigenous women were 3.1 times the rates among all women in Canada. Similarly, age-standardized rates of NCGC among Indigenous NT residents were comparable to global regions where there is a high burden of NCGC. This study has, for the first time, quantified the incidence of CGC and NCGC for the NT and YT, providing new insights into the burden of these cancers among northern Canadian populations.

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Anatomy of the stomach

Cited by 14 publications

References 1 publication

The dynamic gastric environment and its impact on drug and formulation behaviour

The dynamic gastric environment and its impact on drug and formulation behaviour

Exploring the link between gastric motility and intragastric drug distribution in man

Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites

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