Anatomy of the Eye and Orbit.

Duggan, W. F.

doi:10.1001/archopht.1933.00830060147017

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Koniocellular neurons are located in between those laminae. Layers 2, 3 and 5 receive fibers from the ipsilateral eye, whereas layers 1, 4 and 6 receive fibers from the contralateral eye [3]. I.e., each layer receives information from one eye only.…”

Section: Introductionmentioning

confidence: 99%

Deep Learning-Supported Cytoarchitectonic Mapping of the Human Lateral Geniculate Body in the BigBrain

Brandstetter

Bolakhrif

Schiffer

et al. 2021

Lecture Notes in Computer Science

View full text Add to dashboard Cite

The human lateral geniculate body (LGB) with its six sickle shaped layers (lam) represents the principal thalamic relay nucleus for the visual system. Cytoarchitectonic analysis serves as the groundtruth for multimodal approaches and studies exploring its function. This technique, however, requires experienced knowledge about human neuroanatomy and is costly in terms of time. Here we mapped the six layers of the LGB manually in serial, histological sections of the BigBrain, a high-resolution model of the human brain, whereby their extent was manually labeled in every 30th section in both hemispheres. These maps were then used to train a deep learning algorithm in order to predict the borders on sections in-between these sections. These delineations needed to be performed in 1 µm scans of the tissue sections, for which no exact cross-section alignment is available. Due to the size and number of analyzed sections, this requires to employ high-performance computing. Based on the serial section delineations, high-resolution 3D reconstruction was performed at 20 µm isotropic resolution of the BigBrain model. The 3D reconstruction shows the shape of the human LGB and its sublayers for the first time at cellular precision. It represents a use case to study other complex structures, to visualize their shape and relationship to neighboring structures. Finally, our results could provide reference data of the LGB for modeling and simulation to investigate the dynamics of signal transduction in the visual system.

show abstract

Section: Introductionmentioning

confidence: 99%