“…Besides the etiology of the cardiomyopathy (ischemic versus non-ischemic), factors such as CS anatomy, tributary distribution and final LV lead positioning highly affect the response to CRT. Anatomical obstacles in the CS network (venous valves, stenosis, tortuosity of the target vein, among others) represent a major challenge for the operator [ 2 ]. Concerning CS or branch stenosis, balloon angioplasty seems to achieve high rates of successful transvenous LV lead placement.…”