Anatomy of female puberty: The clinical relevance of developmental changes in the reproductive system

Colvin, Caroline; Abdullatif, Hussein

doi:10.1002/ca.22164

Cited by 33 publications

(8 citation statements)

References 102 publications

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“…Adjustments for body size attenuated relationships with B2 in our analyses, but minimally affected the positive risk for younger PH2 with atopic conditions, suggesting that obesity does not mediate or confound the latter association. BMI, however, may confound associations with B2 because thelarche is triggered by rising estrogen levels, which are synthesized in peripheral adipose tissue; estrogen is less important for PH2, which is initiated by adrenal androgens . Our findings were similar to the British cohort study, which found associations between early menarche and asthma to be minimally affected by adjustments for BMI .…”

Section: Discussionsupporting

confidence: 75%

Younger pubertal age is associated with allergy and other atopic conditions in girls

Hong

Pajak

Teitelbaum

et al. 2014

Pediatric Allergy Immunology

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Background Early menarche is linked to higher incidence of adult asthma, suggesting that earlier puberty may influence type 2 immune response characteristics of allergic diseases. We examined the hypothesis that timing of breast and pubic hair development, which precede menarche, is associated with increased childhood atopic conditions. Methods Girls were enrolled at 6–8 yr of age (2004–2007) in the Breast Cancer and the Environment Research Program Puberty Study and were followed through 2011. Pubertal stages were assessed and atopic conditions were queried annually. Associations of age at pubertal stage 2 for breast or pubic hair development with atopic conditions were assessed using prevalence ratios (PR) or odds ratios (OR) and 95% confidence intervals (CI) from log-binomial regression and generalized estimating equation models, controlling for body mass index and other covariates. A total of 1055 girls with medical and pubertal stage data were included. Results Asthma (ever vs. never) was associated with younger pubarche (≤10 vs. >10 yr, PR = 1.15, CI: 1.04–1.28 adjusted for race/ethnicity and site; PR = 1.13, CI: 1.01–1.25 further adjusted for BMI), but not thelarche. In longitudinal models, risk of developing allergies increased with younger age at pubarche (adjusted OR = 1.60, CI: 1.10–2.34; ≤10 vs. >10 yr). Risks were highest among black girls with earlier pubarche (n = 248/326); for allergies, their fully adjusted OR was 2.35, CI: 1.06–5.19 for pubarche ≤10 vs. >10 yr. Conclusions Atopic conditions during childhood are associated with younger age at pubarche, independent of obesity, and these relationships may vary by racial/ethnic groups.

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Section: Discussionsupporting

confidence: 75%

Younger pubertal age is associated with allergy and other atopic conditions in girls

Hong

Pajak

Teitelbaum

et al. 2014

Pediatric Allergy Immunology

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“…They include oestradiol (the primary oestrogen), oestrone, and oestriol. Oestrogens regulate the maturation and maintenance of the female reproductive system ( McCarthy, 2008 ; Colvin & Abdullatif, 2013 ). Compared to testosterone, much less research has been done on the social and behavioural correlates of oestrogens, although there is some evidence that oestradiol drives female competition and status-seeking behaviour in humans ( Knight & Mehta, 2014 ; Stanton & Edelstein, 2009 ; Stanton & Schultheiss, 2007 ).…”

Section: Microbial Regulation Of Social Signalling Moleculesmentioning

confidence: 99%

“…Researchers have also recently detected microbiome–progestogen associations. Like oestrogens, progestogens are ‘female’ steroid hormones that contribute to female reproductive processes ( Colvin & Abdullatif, 2013 ). However, like oestrogens, progestogens are also present in males in small quantities and contribute to male biology.…”

Section: Microbial Regulation Of Social Signalling Moleculesmentioning

confidence: 99%

The role of the microbiome in the neurobiology of social behaviour

et al. 2020

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Microbes colonise all multicellular life, and the gut microbiome has been shown to influence a range of host physiological and behavioural phenotypes. One of the most intriguing and least understood of these influences lies in the domain of the microbiome's interactions with host social behaviour, with new evidence revealing that the gut microbiome makes important contributions to animal sociality. However, little is known about the biological processes through which the microbiome might influence host social behaviour. Here, we synthesise evidence of the gut microbiome's interactions with various aspects of host sociality, including sociability, social cognition, social stress, and autism. We discuss evidence of microbial associations with the most likely physiological mediators of animal social interaction. These include the structure and function of regions of the ‘social' brain (the amygdala, the prefrontal cortex, and the hippocampus) and the regulation of ‘social’ signalling molecules (glucocorticoids including corticosterone and cortisol, sex hormones including testosterone, oestrogens, and progestogens, neuropeptide hormones such as oxytocin and arginine vasopressin, and monoamine neurotransmitters such as serotonin and dopamine). We also discuss microbiome‐associated host genetic and epigenetic processes relevant to social behaviour. We then review research on microbial interactions with olfaction in insects and mammals, which contribute to social signalling and communication. Following these discussions, we examine evidence of microbial associations with emotion and social behaviour in humans, focussing on psychobiotic studies, microbe–depression correlations, early human development, autism, and issues of statistical power, replication, and causality. We analyse how the putative physiological mediators of the microbiome–sociality connection may be investigated, and discuss issues relating to the interpretation of results. We also suggest that other candidate molecules should be studied, insofar as they exert effects on social behaviour and are known to interact with the microbiome. Finally, we consider different models of the sequence of microbial effects on host physiological development, and how these may contribute to host social behaviour.

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“…Self‐esteem then gradually increases as teenagers transition into adulthood, peaking at age 60 . Impacting this are the significant changes that the female body naturally undergoes during puberty and then again with child bearing and delivery and finally with the menopausal transition. There is a paucity of research focusing on adolescents and requests for cosmetic genital surgery.…”

Section: Discussionmentioning

confidence: 99%

Audit of referrals for concern regarding labial appearance at the Royal Children's Hospital: 2000–2012

McQuillan

Jayasinghe

Grover

2018

J Paediatrics Child Health

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With appropriate education and counselling, the majority of girls with concerns regarding labial appearance can be managed without surgery. Overall, our data support current international policy that female cosmetic genital surgery not be performed in mature minors unless there are specific indications. More research about characteristics of patients referred with labial concerns, definition of labial size and long-term satisfaction of conservative versus surgical methods is necessary to determine the best approach.

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Anatomy of female puberty: The clinical relevance of developmental changes in the reproductive system

Cited by 33 publications

References 102 publications

Younger pubertal age is associated with allergy and other atopic conditions in girls

Younger pubertal age is associated with allergy and other atopic conditions in girls

The role of the microbiome in the neurobiology of social behaviour

Audit of referrals for concern regarding labial appearance at the Royal Children's Hospital: 2000–2012

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