Anatomy of CNS opioid receptors

Mansour, Alfred; Khachaturian, Henry; Lewis, Michael; Akil, Huda; Watson, Stanley J.

doi:10.1016/0166-2236(88)90093-8

Cited by 1,103 publications

(641 citation statements)

References 33 publications

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“…Furthermore, the specific opioid ligand involved in MOR activation in VTA has not been identified. Anatomical studies show both beta-endorphin (Mansour et al, 1988) and enkephalin (Johnson et al, 1980;Fallon and Leslie, 1986) terminals in the VTA, and pharmacological evidence shows that both of these peptides can activate the mesolimbic DA system (Broekkamp et al, 1979;Stinus et al, 1980;Dauge et al, 1992). In addition, recent reports have indicated the presence of the highly MOR-specific ligands endomorphin-1 and -2 in the VTA (Greenwell et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Although the present study focused exclusively on MOR, it is possible that other opioid receptors are also involved in the sex-induced activation of the mesolimbic system. Autoradiographic studies show that delta and kappa opioid receptors are present in the VTA, albeit at much lower densities compared to MOR (Mansour et al, 1987(Mansour et al, , 1988Dilts and Kalivas, 1990;Xia and Haddad, 1991). Furthermore, delta agonists infused into the VTA are 100-1000 times less potent at stimulating DA release in the NAc, while kappa agonists fail to do so altogether (Devine et al, 1993), suggesting that sex-induced activation of the mesolimbic DA pathway occurs primarily via MOR activation.…”

Section: Discussionmentioning

confidence: 99%

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Sexual Behavior and Sex-Associated Environmental Cues Activate the Mesolimbic System in Male Rats

Balfour

Coolen

2003

Neuropsychopharmacol

164

125

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The mesolimbic system plays an important role in the regulation of both pathological behaviors such as drug addiction and normal motivated behaviors such as sexual behavior. The present study investigated the mechanism by which this system is endogenously activated during sexual behavior. Specifically, the effects of sexual experience and sex-related environmental cues on the activation of several components of the mesolimbic system were studied. The mesolimbic system consists of a dopaminergic projection from the ventral tegmental area (VTA) to the nucleus accumbens (NAc). Previous studies suggest that these neurons are under tonic inhibition by local GABA interneurons, which are in turn modulated by mu opioid receptor (MOR) ligands. To test the hypothesis that opioids are acting in the VTA during sexual behavior, visualization of MOR internalization in VTA was used as a marker for ligand-induced activation of the receptor. Significant increases in MOR internalization were observed following copulation or exposure to sex-related environmental cues. The next goal was to determine if sexual behavior activates dopamine neurons in the VTA, using tyrosine hydroxylase as a marker for dopaminergic neurons and Fos-immunoreactivity as a marker for neuronal activation. Significant increases in the percentage of activated dopaminergic neurons were observed following copulation or exposure to sex-related environmental cues. In addition, mating and sex-related cues activated a large population of nondopaminergic neurons in VTA as well as neurons in both the NAc Core and Shell. Taken together, our results provide functional neuroanatomical evidence that the mesolimbic system is activated by both sexual behavior and exposure to sex-related environmental cues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sexual Behavior and Sex-Associated Environmental Cues Activate the Mesolimbic System in Male Rats

Balfour

Coolen

2003

Neuropsychopharmacol

164

125

View full text Add to dashboard Cite

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“…Acute administration of AMPH or METH is known to increase endogenous opioid contents [35], and mesolimbic structures such as VTA and NAcc receive β-endorphin containing fibers [29]. Although opioid agonists had been known to increase the firing rate of dopamine neurons [31] and increase dopamine levels [20] in the VTA, the character of opioidergic system in chronic use of psychostimulants still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone

Chiu

2005

Brain Research Bulletin

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Repeated intermittent exposure to psychostimulants was found to produce behavioral sensitization. The present study was designed to establish a mouse model and by which to investigate whether opioidergic system plays a role in methamphetamine-induced behavioral sensitization. Mice injected with 2.5 mg/kg of methamphetamine once a day for 7 consecutive days showed behavioral sensitization after challenge with 0.3125 mg/kg of the drug on day 11, whereas mice injected with a lower daily dose (1.25 mg/kg) did not. Mice received daily injections with either 1.25 or 2.5 mg/kg of methamphetamine showed behavioral sensitization after challenge with 1.25 mg/kg of the drug on days 11, 21, and 28. To investigate the role of opioidergic system in the induction and expression of behavioral sensitization, long-acting but non-selective opioid antagonist naltrexone was administrated prior to the daily injections of and challenge with methamphetamine, respectively. Our results show that the expressions of behavioral sensitization were attenuated by pretreatment with 10 or 20 mg/kg of naltrexone either during the induction period or before methamphetamine challenge when they were tested on days 11 and 21. These results indicate that repeated injection with methamphetamine dose-dependently induced behavioral sensitization in mice, and suggest the involvement of opioid receptors in the induction and expression of methamphetamine-induced behavioral sensitization.

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“…The cortical distributions of dopaminergic and opiate receptors (Joyce and Meador-Woodruff 1997;Mansour et al 1988) might be expected to lead to different patterns of cognitive impairment among stimulant and opiate abusers. For example, dopamine (DA) D1 receptors are mainly present in the anterior neocortex (especially prefrontal cortex).…”

mentioning

confidence: 99%

Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers

Ornstein

Iddon

Baldacchino

et al. 2000

Neuropsychopharmacology

383

289

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Anatomy of CNS opioid receptors

Abstract: This paper reviews some of the findings that have led to this conclusion and the anatomical distributions of these sites in the rat brain. Their relation to the opioid peptides and some of the proposed functions mediated by these receptor systems are also discussed.

Cited by 1,103 publications

References 33 publications

Sexual Behavior and Sex-Associated Environmental Cues Activate the Mesolimbic System in Male Rats

Sexual Behavior and Sex-Associated Environmental Cues Activate the Mesolimbic System in Male Rats

Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone

Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers

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