Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography

Abstract

The results were consistent with manganese-enhanced MRI studies, despite the much lower manganese concentration used for PET (100 mM Mn for MRI compared to ~ 0.05 mM for PET). This indicates that uptake and transport mechanisms are comparable even at low PET doses. This helps establish the use of manganese-based radiotracers in both preclinical and clinical studies to assess anatomy, function, and connectivity.

Production and Use of the First-Row Transition Metal PET Radionuclides43,44Sc,52Mn, and45Ti

“…52g Mn has been used in several imaging applications. For example, recent studies showed that Mn 21 can enter neurons, and thus, 52g Mn has been studied as a neural imaging agent (37). Because manganese is also used as a contrast agent in manganese-enhanced MRI, MRI tools can benefit from the use of 52g Mn to enhance the understanding of the pharmacokinetics of these agents (38).…”

“…Another interesting study showed the uptake of 52g Mn-Mn 21 in monkeys after nostril administration of the radiotracer (37). Brain uptake in rhesus macaque monkeys was determined over 8 sessions with at least 6 mo between each session.…”

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

“…The sensitivity of PET is much higher than that of MRI, and PET uses a lower dose of manganese for imaging. In particular, the emergence of Mn-PET/MRI will be beneficial for clinical applications of Mn 2+ (180,181). Further developments in material science are expected to produce safe manganesecontaining contrast agents.…”

Manganese in PET imaging: Opportunities and challenges

“…Saar et al studied the biodistribution of 51 Mn and 52g Mn in different organs . Further, they investigated the neuronal olfactory pathway in monkeys and rodents using nasally administrated 51 Mn and 52g Mn.…”