Anatomy and white-matter connections of the precuneus

Tanglay, Onur; Young, Isabella M.; Dadario, Nicholas B.; Briggs, Robert G.; Fonseka, R. Dineth; Dhanaraj, Vukshitha; Hormovas, Jorge; Lin, Yueh‐Hsin; Sughrue, Michael E.

doi:10.1007/s11682-021-00529-1

Cited by 57 publications

(47 citation statements)

References 75 publications

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“…The AG is located in the posterior of the inferior parietal lobe, and serves as a central hub for different subsystems ( 46 ). The AG plays a role in semantic processing, reading, and word comprehension, and is linked to higher memory scores ( 47 ). Over the course of SCH progression, patients exhibit increases in brain damage, with chronic SCH patients exhibiting the disruption of normal bilateral AG asymmetry and a reversal of the normal left > right asymmetry relative to HC individuals ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

Gao

Tong

Huang³

et al. 2022

Front. Psychiatry

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ObjectiveSchizophrenia (SCH) is primarily diagnosed based on specific clinical symptoms, with the lack of any objective SCH-related biomarkers often resulting in patient misdiagnosis and the underdiagnosis of this condition. This study was developed to assess the utility of amplitude of low-frequency fluctuation (ALFF) values analyzed via support vector machine (SVM) methods as a means of diagnosing SCH.MethodsIn total, 131 SCH patients and 128 age- and gender-matched healthy control (HC) individuals underwent resting-state functional magnetic resonance imaging (rs-fMRI), with the resultant data then being analyzed using ALFF values and SVM methods.ResultsRelative to HC individuals, patients with SCH exhibited ALFF reductions in the left angular gyrus (AG), fusiform gyrus, anterior cingulate cortex (ACC), right cerebellum, bilateral middle temporal gyrus (MTG), and precuneus (PCu) regions. No SCH patient brain regions exhibited significant increases in ALFF relative to HC individuals. SVM results indicated that reductions in ALFF values in the bilateral PCu can be used to effectively differentiate between SCH patients and HCs with respective accuracy, sensitivity, and specificity values of 73.36, 91.60, and 54.69%.ConclusionThese data indicate that SCH patients may exhibit characteristic reductions in regional brain activity, with decreased ALFF values of the bilateral PCu potentially offering value as a candidate biomarker capable of distinguishing between SCH patients and HCs.

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Section: Discussionmentioning

confidence: 99%

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

Gao

Tong

Huang³

et al. 2022

Front. Psychiatry

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“…Particular attention may deserve the cingulate cortex, which has both a relevant topological role (an intermediate spatial position bridging the anterior and posterior blocks) and is a key element of global connectivity (Maldonado et al, 2012; Rolls, 2019; Wu et al, 2016), possibly associated with human‐specific features (Ardesch, Scholtens, Li, et al, 2019). As a spatial bridge between the anterior and posterior district, it is a key pathway between the precuneus and the frontal cortex (Tanglay et al, 2021; Wenderoth et al, 2005). With this in mind, we may wonder whether the development of the prefrontal cortex in humans and apes (Parks & Smaers, 2018; Semendeferi et al, 2002) has influenced their topological brain parameters in terms of network proximity.…”

Section: Discussionmentioning

confidence: 99%

A network approach to the topological organization of the Brodmann map

Bruner

2022

The Anatomical Record

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Brain morphology is the result of functional factors associated with cortical areas, but it is also influenced by structural aspects due to physical and spatial constraints. Despite the noticeable advances in brain mapping, Brodmann's map is still used in many research fields that rely on macroscopic cortical features for practical or theoretical issues. Here, the topological relationships among the Brodmann areas were modeled according to the principles of network analysis, in order to provide a synthetic view of their spatial properties following a criterion of contiguity. The model evidences the importance of the parieto-temporal region in terms of biological burden and topological complexity. The retrosplenial region is particularly influenced by spatial constraints, and the cingulate cortex occupies a position that bridges the anterior and posterior topological blocks. Such spatial framework should be taken into account when dealing with brain morphology in both ontogeny and phylogeny.

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“…The DMN is the neural basis of many important functional activities of humans, including cognition, consciousness, etc. ( Hu et al, 2022 ; Oyarzabal et al, 2022 ; Wang et al, 2022 ) It participates in a lot of neurophysiological processes, such as the evaluation of episodic memory, introspection, monitoring of the external environment, emotional processing, and cognitive control ( Greicius et al, 2003 ; Arsenault et al, 2018 ; Li J. et al, 2021 ; Oyarzabal et al, 2022 ; Tanglay et al, 2022 ). Studies have confirmed that in the state of chronic pain, the activation-inactivation mechanics of the DMN is in disorder ( Baliki et al, 2008 ; Shen et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity

Yang

Guo³

et al. 2022

Front. Neurosci.

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IntroductionPrimary dysmenorrhea (PDM) is a common gynecological disease and chronic pain disorder. Moxibustion, a form of traditional Chinese medicine therapy, has proven to be effective for PDM. However, the central mechanisms of PDM and moxibustion for PDM are still unclear. This study aims to explore the potential central mechanism of PDM and clarify the possible mechanism of moxibustion for relieving pain.Materials and methodsA total of 23 PDM patients and 23 matched healthy controls (HCs) were enrolled. For PDM patients, resting-state functional magnetic resonance imaging (rs-fMRI) data were collected pre- and post-moxibustion treatment of 3 consecutive menstrual cycles, respectively. For HCs, rs-fMRI data were collected in the baseline. The resting-state functional connectivity strength (rs-FCS) analysis and the resting-state functional connectivity (rs-FC) analysis based on the region of interest (ROI) were combined to be conducted.ResultsCompared to HCs, PDM patients showed weaker rs-FCS in the left inferior frontal gyrus (IFG). After the moxibustion treatment, rs-FCS in the left IFG was increased with clinical improvement. Then, the left IFG was chosen as ROI, and the rs-FC analysis was conducted. It showed that the left IFG rs-FC in the bilateral anterior cingulate cortex (ACC)/middle cingulate cortex (MCC), the left posterior cingulate cortex (PCC)/precuneus (PCU), and the left parahippocampal gyrus (PHG) decreased after moxibustion treatment, most of which belong to the default mode network (DMN).ConclusionOur results highlight the role of the left IFG and the DMN in PDM. Specifically, the central mechanism of moxibustion for analgesia may be related to modulating the disorders of the reappraisal and processing of pain stimuli through influencing the cognition of pain.

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Anatomy and white-matter connections of the precuneus

Cited by 57 publications

References 75 publications

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

A network approach to the topological organization of the Brodmann map

Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity

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