Anatomy and White Matter Connections of the Middle Frontal Gyrus

Briggs, Robert G.; Lin, Yueh‐Hsin; Dadario, Nicholas B.; Kim, Sihyong J.; Young, Isabella M.; Bai, Michael Y.; Dhanaraj, Vukshitha; Fonseka, R. Dineth; Hormovas, Jorge; Tanglay, Onur; Chakraborty, Arijit; Milligan, Ty M; Abraham, Carol J.; Anderson, Christopher; Palejwala, Ali H.; Conner, Andrew K.; O’Donoghue, Daniel L.; Sughrue, Michael E.

doi:10.1016/j.wneu.2021.03.045

Cited by 67 publications

(50 citation statements)

References 55 publications

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“…The MFG is an important centre associated with attention. Previous research has shown that this area plays a key role in the reorientation of attention, working memory, speech, and language comprehension [47]. A study on vestibular migraine found increased FC between the left thalamus and the right MFG [16].…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study

et al. 2022

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Why carry out this study?Migraine is considered to be one of the most serious chronic dysfunctional disorders worldwide, with a high prevalence and significant loss and damage to personal health and socioeconomic well-being.The etiology of migraine is still unclear, effective treatments are lacking, and further research into its pathogenesis is urgently needed. At present, structural MRI of patients with migraine has not revealed any problems and functional MRI (fMRI) is expected to reveal biomarkers. What was learned from this study?This study used fMRI techniques to investigate the functional connectivity differences in the brain between patients with migraine and healthy controls. Compared with healthy controls, the patients exhibited abnormal voxelmirrored homotopic connectivity and functional connectivity in the bilateral thalamus. This may be related to the fact that the thalamus is an important sensory relay hub.These results provide solid evidence for the pathogenesis of migraine. In the future, studies with larger samples will be needed to further validate these findings.

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Section: Discussionmentioning

confidence: 99%

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study

et al. 2022

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“…Previous studies showed that the lateral prefrontal cortex had a critical role in male sexual arousal and sexual behavior ( 27 , 69 ). The middle frontal gyrus (orbital part) is a core region of the central executive network in the brain, which is primarily implicated in cognitive control, response inhibition, and attention ( 60 , 70 ). The previous study demonstrated that patients with minor changes (fewer subregions) of the lateral prefrontal cortex exhibited inhibition in behavior while patients with superior abnormalities (more subregions) of this region had both aberrant sexual inhibition and insufficient cognition and attention to sexual targets ( 27 , 71 ).…”

Section: Discussionmentioning

confidence: 99%

Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study

et al. 2022

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BackgroundSexual dysfunction, namely, erectile dysfunction (ED) and premature ejaculation (PE), has been found to be associated with abnormal structural connectivity in the brain. Previous studies have mainly focused on a single disorder, however, convergent and divergent structural connectivity patterns of the brain network between ED and PE remain poorly understood.MethodsT1-weighted structural data and diffusion tensor imaging data of 28 patients with psychological ED, 28 patients with lifelong PE (LPE), and 28 healthy controls (HCs) were obtained to map the white matter (WM) brain networks. Then, the graph-theoretical method was applied to investigate the differences of network properties (small-world measures) of the WM network between patients with ED and LPE. Furthermore, nodal segregative and integrative parameters (nodal clustering coefficient and characteristic path length) were also explored between these patients.ResultsSmall-world architecture of the brain networks were identified for both psychological ED and LPE groups. However, patients with ED exhibited increased average characteristic path length of the brain network when compared with patients with LPE and HCs. No significant difference was found in the average characteristic path length between patients with LPE and HCs. Moreover, increased nodal characteristic path length was found in the right middle frontal gyrus (orbital part) of patients with ED and LPE when compared with HCs. In addition, patients with ED had increased nodal characteristic path length in the right middle frontal gyrus (orbital part) when compared with patients with LPE.ConclusionTogether, our results demonstrated that decreased integration of the right middle frontal gyrus (orbital part) might be a convergent neuropathological basis for both psychological ED and LPE. In addition, patients with ED also exhibited decreased integration in the whole WM brain network, which was not found in patients with LPE. Therefore, altered integration of the whole brain network might be the divergent structural connectivity patterns for psychological ED and LPE.

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“…We found that individuals experiencing more fatigue had weaker FC between the non-lesioned supramarginal gyrus and middle frontal gyrus compared to those who did not experience fatigue. Recent evidence suggests that these areas are structurally connected via the superior longitudinal fasciculus 31 . Perhaps surprisingly, the weaker connectivity seen in fatigued participants re ected the pattern in typically developed participants, where there was virtually no functional connectivity between these areas.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in perinatal stroke is associated with resting-state functional connectivity

Wrightson

Carlson

Condliffe

et al. 2022

Preprint

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Fatigue is prevalent in youth with perinatal stroke, but the causes are unclear. Predictive coding models of adult post-stroke fatigue suggest that fatigue may arise from dysfunction in predictive processing networks. To date, the association between fatigue and neural network connectivity in youth with perinatal stroke has not been examined. The present study examined the association between fatigue and the functional connectivity of predictive processing neural networks, measured using resting-state functional magnetic resonance imaging, in individuals with perinatal stroke. Participants who reported experiencing fatigue had weaker functional connectivity between the non-lesioned middle frontal and supramarginal gyri and between the non-lesioned intracalcarine cortex and the lesioned paracingulate cortex. In contrast, participants reporting fatigue had stronger functional connectivity between the lesioned inferior temporal gyrus and non-lesioned insula. These results suggest that fatigue in youth with hemiparetic cerebral palsy caused by perinatal stroke is associated with the functional connectivity of hubs previously associated with predictive processing and fatigue. These results suggest potential cortical and behavioral targets for the treatment of fatigue in individuals with perinatal stroke.

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Anatomy and White Matter Connections of the Middle Frontal Gyrus

Cited by 67 publications

References 55 publications

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study

Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study

Fatigue in perinatal stroke is associated with resting-state functional connectivity

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