Anatomy and Development of the Thyroid

Felice, Mario De; Lauro, R

doi:10.1016/b978-1-4160-5583-9.00072-1

Cited by 4 publications

(2 citation statements)

References 194 publications

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“…(4) Although most thyroid nodules are benign and do not require treatment, some benign nodules may require treatment for associated symptoms and/or because of cosmetic problems. (5)…”

Section: Introductionmentioning

confidence: 99%

Comparative Study between Sonographic Finding, Fine Needle Aspiration Cytology and Surgical Pathology In Multi-nodular Goiter

El-Deen

El-Maola

Elsewefy

et al. 2019

Minia Journal of Medical Research

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Introduction: Thyroid nodules constitute a frequently seen clinical problem, and the incidence of thyroid nodules has increased with the recently increased use of thyroid ultrasonography (US). Aim of the work: Evaluation of validity and feasibility of different diagnostic tools in multi-nodular goiter. Also, evaluation of sensitivity , specificity and their impact on surgical decision.Patients & Methods: This study was conducted in Minia university hospital in prospective study including 90 patients with multi-nodular goiter thorough history and clinical examination. Results: In this prospective study of 90 cases with nodular goiter. Conclusion: In our study,it was found that USG and FNAC have a high specificity.

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“…(4) Although most thyroid nodules are benign and do not require treatment, some benign nodules may require treatment for associated symptoms and/or because of cosmetic problems. (5)…”

Section: Introductionmentioning

confidence: 99%

Comparative Study between Sonographic Finding, Fine Needle Aspiration Cytology and Surgical Pathology In Multi-nodular Goiter

El-Deen

El-Maola

Elsewefy

et al. 2019

Minia Journal of Medical Research

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“…As the biggest endocrine organ in humans, the thyroid gland is mainly composed of follicular cells and parafollicular cells (C cells), which originate from a median endodermal mass in the region of the tongue (foramen cecum) and from the ultimobranchial body originating from the fourth branchial pouch, respectively 1 . But interestingly, other primary histological components are sometimes seen in thyroid lesions, such as benign squamous metaplasia, squamous cell carcinoma (SCC), mucoepidermoid carcinoma and intrathyroid epithelial thymoma/carcinoma showing thymus‐like differentiation (ITET/CASTLE) 2–7 .…”

mentioning

confidence: 99%

Squamous cell components in a thyroid follicular adenoma: Significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses

Bai

Mori

Liu

et al. 2011

Pathology International

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Squamous cells in the thyroid appear in a variety of conditions, including adenomatous goiters, malignant neoplasms, inflammatory diseases, and embryonic remnants. However the origin of the squamous cells is still under dispute. Here we report a case of an encapsulated follicular cell tumor consisting of follicular cells, basaloid squamous cells, and morphologically intermediate cells. The patient was a 66-year-old man presenting with a progressively enlarged painless lump in the right side of his neck. A solid tumor with encapsulation in the right lobe was confirmed by simple right lobe thyroid lobectomy. This tumor demonstrated heterogeneous immunoreactions for Ki-67, thyroglobulin, thyroid transcription factor-1, and pan-cytokeratin (AE1/AE3), in that the intermediate cells had intermediate immunoreactivity between follicular and basaloid squamous cells. p63 was positive in the periphery layer of tumor cell nests of the intermediate and squamous cells. A completely negative immunoreaction was noted for high molecular weight cytokeratin (34βE12), calcitonin, CEA, p53, CD5, and rearranged in transformation (RET). Mutational analysis of BRAF and RAS were negative. These results strongly suggest that this tumor is a follicular adenoma, and that the squamous component originated from follicular cells undergoing squamous metaplasia. The patient has been disease free more than 40 months after surgery.

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