Anatomische Bilder zur sekretorischen Umwandlung der glandulären Hyperplasie

Gruner, Wolfgang

doi:10.1007/bf01725251

Cited by 14 publications

(2 citation statements)

References 4 publications

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“…!i i ĩl l l I!i i l~l l l!ĩ~. ~~illll~illllllillllllllllllllllllll~lli~l~ metrium (Hamblen, 1947;Greenblatt and Barfield, 1951;Gruner, 1942). It is assumed that, in the normal secretory phase, 10 mg. estradiol is effective (Ober et al, 1954).…”

Section: Gynecologic Disordersmentioning

confidence: 99%

Observations on the Role of Progestational Agents in Human Gynecologic Disorders and Pregnancy Complications

Boschann

1958

Ann NY Acad Sci

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In the first part of my paper I propose to report the clinical experiments on surgical castrates performed by my associates and myself to establish standard dosages for parenterally and orally administered progestational agents. I n the second part, I shall discuss the practical therapeutic application of these basic experiments. I n gynecological patients these clinical applications concern functional uterine bleeding, amenorrhea, shortened menstrual cycle, and genital hypoplasia with dysmenorrhea and sterility. In obstetrical patients the clinical applications concern threatened and habitual abortion and protection of pregnancy during surgical procedures. CLINICAL EXPERIMENTSThe purpose of our clinical experiments was the standardization of progestational agents in humans. Animal experiments could not be compared directly with the actual effect in humans. There were also discrepancies between the results of the Allen-Doisy test and the clinical results on amenorrheic patients when testing estrogens. We based our experiments on the test on the estrogen-primed endometrium, as initiated by Carl Kaufmann in 1932.FIGURE la shows the scheme devised by Kaufmann in 1933. The endometrium is proliferated by five 5-mg. injections of estradiol benzoate every fourth day, from the first to the fifteenth day of the test cycle. From the nineteenth to the twenty-third day, 5 mg. of progesterone in an oily solution is injected daily. Two days after the last injection there will be uterine bleeding of about 3 days' duration. We have modified this test by administering estrogens also during the second part of the test cycle, as it seems to correspond with the more recent knowledge of the hormonal conditions during the menstrual cycle. This test on the same patient, using the same experimental method, generally gives uniform results, as we could observe in our material on 264 artificial cycles in 11 castrates. I t seems permissible, then, to draw comparative conclusions on the progestational activity and duration of effect of the different tested substances.In addition to the experiments on surgical castrates, we also observed the onset of withdrawal bleeding in amenorrheic patients and the reaction of the vaginal epithelium. The epithelial changes in the vagina also permitted an assessment of whether or not a test substance had an estrogenic effect.FIGURE 2 shows the effect of free progesterone in oily solution on the endometrium primed with five 5-mg. doses of estradiol benzoate. Following the administration of five 10-mg. doses of progesterone from the nineteenth 727

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Section: Gynecologic Disordersmentioning

confidence: 99%

Observations on the Role of Progestational Agents in Human Gynecologic Disorders and Pregnancy Complications

Boschann

1958

Ann NY Acad Sci

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“…Άλλες καταστάσεις, οι οποίες μπορεί να προκαλέσουν υπερπλασία ενδομητρίου είναι: επίμονο ωοθυλάκο (Schröder, 1915), πολυκυστική ωοθήκη, στρωματική υπερπλασία (Novak και συν., 1965, Bilde, 1967, υπερπλασία των πυλαίων ωοθηκικών κυττάρων (Husslein, 1948, Dhom, 1952, θηκώματα (Limburg, 1947, Fienberg, 1958, Kottmeir, 1959. Η αδενωματώδης-κυστική υπερπλασία του ενδομητρίου, είναι συχνό τερη μεταξύ 41-50 χρόνων, μια μεταβατική περίοδο για την ωοθηκική λειτουργία, όπως αποδεικνύεται από την έντονη διακύμανση της παρα γωγής οιστρογόνων (Grüner, 1942, Schröder, 1954.…”

Section: υπερπλασια ενδομητριουunclassified