Anatomically‐based transoral surgical approach to early‐stage oral tongue squamous cell carcinoma

Calabrese, Luca; Pietrobon, Giacomo; Fazio, Enrico; Abousiam, Monir; Awny, Shadi; Bruschini, Roberto; Accorona, Remo

doi:10.1002/hed.26095

Cited by 13 publications

(8 citation statements)

References 8 publications

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“…And it enables surgical resection with enough margin simultaneously with primary repair and also leave minimal cosmetic and functional defects. 13) Presence of neck lymph node metastasis is one of the most important prognostic factors of head and neck cancer. Classic or modified radical neck dissection is a treatment of choice of nodal metastasis.…”

Section: Discussionmentioning

confidence: 99%

Recurred Minor Salivary Gland Cancer in Base of Tongue, Endoscopic Neck Management

Yoon¹,

Lee²,

Song³

et al. 2021

Korean J Otorhinolaryngol-Head Neck Surg

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A 45-year-old female who presented with a salivary gland tumor on the oral and base of the tongue underwent surgery via intraoral approach. It led to a recurrence of the primary site and metastasis to bilateral cervical lymph nodes within 5 years of surgery. We performed resection of the recurred tumor via transoral approach and endoscope assisted neck dissection via retroauricular approach. The patient has been alive for 5 years without recurrence or any complications. We report on this case where a minimally invasive approach was used to obtain excellent cosmetic results and outstanding surgical outcomes.

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Section: Discussionmentioning

confidence: 99%

Recurred Minor Salivary Gland Cancer in Base of Tongue, Endoscopic Neck Management

Yoon¹,

Lee²,

Song³

et al. 2021

Korean J Otorhinolaryngol-Head Neck Surg

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“…As a common and highly malignant oral squamous cell carcinoma, tongue squamous cell carcinoma (TSCC) [1] TSCC can easily lead to disorders of swallowing, chewing, speech thereby seriously influencing the quality of life of the patient [2]. It also has a poor prognosis and a high local recurrence rate, which lead to reduced overall survival rate.…”

Section: Introductionmentioning

confidence: 99%

Ailanthone decreases cell viability in tongue squamous cell carcinoma via PI3K/AKT pathway

wang¹,

Chen²,

Zhu³

et al. 2021

Preprint

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To investigate the anti-tumor effect and mechanisms of ailanthone (AIL) in tongue squamous cell carcinoma (TSCC). The viability and apoptotic cell number of TCA8113 and Cal-27 cells declined and increased considerably following AIL. Hoechst 33258 staining revealed chromatin aggregation after exposure to AIL. Along with an accumulation of cleaved caspase-9, caspase-3, and PARP1, Bcl-2/Bax ratio and the levels of caspase-3, caspase-9 and PARP1 reduced after exposure to AIL treatment. Subjecting Cal-27 cells to AIL treatment led to the arrestment of the cell cycle at the G2/M phase. Nevertheless, the cell cycle of AIL-treated TCA8113 cells did not change significantly. Following AIL treatment, a decline in the expression of CDK1 and cyclin B1 was manifested by Western Blot. The p-AKT as well as the expression level of p-PI3K underwent a significant downregulation by AIL in both cells. The outcome furnishes a valuable understanding of the potential applications of AIL in treating TSCC.

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“…For example, Chandler et al showed that local recurrence was higher with muscle invasion than DOI, although the positive predictive value of muscle invasion in regards to nodal status was slightly less than DOI [7]. Additionally, routes of tumoral spread in the oral tongue through muscle fibers should be taken into account to plan a complete resection through a standardized and replicable surgical technique [8]. Therefore, it is interesting to compare the aspects of tumor diffusion in lingual musculature on the basis of anatomical and surgical findings with the most recent basic research data [9].…”

Section: Introductionmentioning

confidence: 99%

From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research

Calabrese

Bizzoca

Grigolato

et al. 2020

Life

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Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved. Depth of invasion, pattern of invasion such as tumor budding grade, lingual lymph node metastasis in early stages, collective cell migration and circulating tumor cells in peripheral blood are some examples of the mechanisms that are currently receiving increasing attention in the evaluation of the prognosis of tongue cancers. Anatomic-based surgery showed that it is possible to improve loco-regional control of tongue cancer. In patients with a “T-N tract involvement”, there is significantly more distant recurrence (40%) in patients undergoing a compartmental tongue surgery. In general, the neoplastic infiltration of the lingual muscles is traced back to the finding of neoplastic tissue along the course of a muscle; however, the muscle fibers, due to their spatial conformation and the organization of the extracellular matrix, could influence the movement of tumor cells through the muscle, leaving its three-dimensional structure unchanged. We need to exclude the possibility that tongue muscle fibers represent a mechanism for the diffusion of cancer cells without muscle invasion.

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Anatomically‐based transoral surgical approach to early‐stage oral tongue squamous cell carcinoma

Cited by 13 publications

References 8 publications

Recurred Minor Salivary Gland Cancer in Base of Tongue, Endoscopic Neck Management

Recurred Minor Salivary Gland Cancer in Base of Tongue, Endoscopic Neck Management

Ailanthone decreases cell viability in tongue squamous cell carcinoma via PI3K/AKT pathway

From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research

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