Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain

Ose, Takayuki; Autio, Joonas; Ohno, Masahiro; Frey, Stephen; Uematsu, Akiko; Kawasaki, Akihiro; Takeda, Chiho; Hori, Yuki; Nishigori, Kantaro; Nakako, Tomokazu; Yokoyama, Chihiro; Nagata, Hidetaka; Yamamori, Tetsuo; Essen, David C. Van; Glasser, Matthew F.; Watabe, Hiroshi; Hayashi, Takuya

doi:10.1016/j.neuroimage.2022.118965

Cited by 13 publications

(9 citation statements)

References 101 publications

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“…This putative region is thought to be as slender as 2.8 mm in its width, based on observations in macaques. If a similar narrow strip were to exist in marmoset, its estimated width would be a mere 270 micrometers, inferred by the relative cortical surface sizes of macaque and marmoset 29,30 . It is possible that our imaging overlooked such a small structure.…”

Section: Discussionmentioning

confidence: 99%

Naturalistic Movies and Encoding Analysis Redefine Areal Borders in Primate Visual Cortex

Shimaoka,

Wong,

Rosa

et al. 2023

Preprint

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Accurate definition of the borders of cortical visual areas is essential for the study of neuronal processes leading to perception. However, data used for definition of areal boundaries has suffered from issues related to resolution, uniform coverage, or suitability for objective analysis, leading to ambiguity. Here, we present a novel approach that combines widefield optical imaging, presentation of naturalistic movies, and encoding model analysis, to objectively define borders in the primate extrastriate cortex. We applied this method to test conflicting hypotheses about the third-tier visual cortex, where areal boundaries have remained controversial. The results support a hypothesis whereby an area contains representations of both the upper and lower contralateral quadrants (DM) is located immediate anterior to V2, and unveil pronounced tuning preferences in the third-tier areas. High-density electrophysiological recordings with a Neuropixels probe confirm these findings. Our encoding-model approach offers a powerful, objective way to disambiguate areal boundaries.

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Section: Discussionmentioning

confidence: 99%

Naturalistic Movies and Encoding Analysis Redefine Areal Borders in Primate Visual Cortex

Shimaoka,

Wong,

Rosa

et al. 2023

Preprint

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“…Robot-assisted neuronavigation systems is one such technology that is becoming increasingly popular and allows for reduction of targeting error beyond the gold standard of image-guided stereotaxy (Ose et al, 2022). Additionally, this technology allows for a reduction in the surgical time and provides better patient outcome as presented in the human neurosurgery literature (Fomenko & Serletis, 2018;Joswig et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

A method for chronic and semi-chronic microelectrode array implantation in deep brain structures using image guided neuronavigation

Mahmoudian

Dalal

Lau

et al. 2022

Preprint

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Precise targeting of deep brain structures in humans and large animal models has been a challenge for neuroscientists. Conventional protocols used in animal models typically require large access chambers which are prone to infection and involve assembly and implantation of complex microdrives for semi-chronic applications. Here we present a methodology for improving targeting of subcortical structures in large animals such as macaque monkeys, using image guided neuronavigation. Design of custom cranial caps allowed for incorporation of stable fiducial markers, required for increased targeting accuracy in neuronavigation procedures, resulting in an average targeting error of 1.6 mm over three implantations. Incorporation of anchor bolt chambers, commonly used in human neurosurgery, provided a minimally invasive entrance to the brain parenchyma, allowing for chronic recordings. By leveraging existing 3D printing technology, we fabricated an anchor bolt-mounted microdrive for semi-chronic applications. Our protocol leverages commercially available tools for implantation, decreases the risk of infection and complications of open craniotomies, and improves the accuracy and precision of chronic electrode implantations targeting deep brain structures in large animal models.

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“…Although we conducted ICMS in individual animals to account for the effects of individual differences, this was not sufficient to accurately identify the borders. Registration of the imaging field to a brain atlas with MRI would be useful to more accurately identify the areas (Ose et al, 2022).…”

Section: Limitationsmentioning

confidence: 99%

Dynamics of motor direction representation in the primate premotor and primary motor cortices during sensorimotor learning

Ebina,

Sasagawa,

Hong

et al. 2023

Preprint

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Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). However, how PM- and M1-specific reorganization occurs in primates remains unclear. We conducted calcium imaging of these areas in common marmosets while they learned a two-target reaching (pull/push) task. Throughout learning, the dorsorostral PM (PMdr) showed peak activity earlier than the dorsocaudal PM (PMdc) and M1. PMdr showed decreased representation of newly introduced (push) movement, whereas PMdc and M1 maintained high representation. Many task-related neurons in PMdc and M1 exhibited a strong preference to either movement direction. PMdc neurons dynamically switched their preferred direction, whereas M1 neurons stably retained their preferred direction. Differences in preferred direction between adjacent neurons in PMdc increased during learning. These results suggest that in primate sensorimotor learning, dynamic motor representation in PMdc converts the cognitive sensorimotor signals of PMdr to stable and specific motor representation of M1.

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Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain

Cited by 13 publications

References 101 publications

Naturalistic Movies and Encoding Analysis Redefine Areal Borders in Primate Visual Cortex

Naturalistic Movies and Encoding Analysis Redefine Areal Borders in Primate Visual Cortex

A method for chronic and semi-chronic microelectrode array implantation in deep brain structures using image guided neuronavigation

Dynamics of motor direction representation in the primate premotor and primary motor cortices during sensorimotor learning

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