Anatomical parcellation of the brainstem and cerebellar white matter: a preliminary probabilistic tractography study at 3 T

Habas, Christophe; Cabanis, E. A.

doi:10.1007/s00234-007-0267-4

Cited by 125 publications

(107 citation statements)

References 17 publications

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“…The seed region of interest was given at the area of the spinothalamic tract in the posterolateral medulla (posterior to the inferior olivary nucleus and anterior to the inferior cerebellar peduncle) for both STPs, as described in a brain atlas. [22][23][24][25][26] Target regions of interest for the hand and leg were selected according to known anatomy (region of interest for the hand was the postcentral gyrus posterior to the precentral knob; and region of interest for the leg was the postcentral gyrus posterior to the leg somatotopy of the precentral gyrus) on the non-diffusion-weighted (b0) image (Fig 1).…”

Section: Fiber Trackingmentioning

confidence: 99%

Probabilistic Somatotopy of the Spinothalamic Pathway at the Ventroposterolateral Nucleus of the Thalamus in the Human Brain

Hong¹,

Kwon²,

Jang³

2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The STP has been regarded as the most plausible neural tract responsible for pathogenesis of central poststroke pain. The VPL nucleus has been a target for neurosurgical procedures for control of central poststroke pain. However, to our knowledge, no DTI studies have been conducted to investigate the somatotopic location of the STP at the VPL nucleus of the thalamus. In the current study, we attempted to investigate this location in the human brain by using a probabilistic tractography technique of DTI.

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Section: Fiber Trackingmentioning

confidence: 99%

Probabilistic Somatotopy of the Spinothalamic Pathway at the Ventroposterolateral Nucleus of the Thalamus in the Human Brain

Hong¹,

Kwon²,

Jang³

2011

AJNR Am J Neuroradiol

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“…The pons has been targeted multiple times in previous DTI studies (8,(19)(20)(21). On one hand, although some of the existing single-shot echo-planar imaging (EPI) studies used more than six diffusion encoding directions (8,21), the achieved spatial resolution was typically low owing to the technical limitations of conventional single-shot EPI.…”

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confidence: 99%

“…On one hand, although some of the existing single-shot echo-planar imaging (EPI) studies used more than six diffusion encoding directions (8,21), the achieved spatial resolution was typically low owing to the technical limitations of conventional single-shot EPI. On the other hand, although some of the existing multishot studies achieved high spatial resolution (22,23), the number of the employed diffusion encoding directions was six to maintain a reasonable total acquisition time.…”

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confidence: 99%

High‐resolution diffusion tensor imaging of the human pons with a reduced field‐of‐view, multishot, variable‐density, spiral acquisition at 3 T

Karampinos

Van

Olivero

et al. 2009

Magnetic Resonance in Med

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Diffusion tensor imaging of localized anatomic regions, such as brainstem, cervical spinal cord, and optic nerve, is challenging because of the existence of significant susceptibility differences, severe physiologic motion in the surrounding tissues, and the need for high spatial resolution to resolve the underlying complex neuroarchitecture. The aim of the methodology presented here is to achieve high-resolution diffusion tensor imaging in localized regions of the central nervous system that is motion insensitive and immune to susceptibility while acquiring a set of two-dimensional images with more than six diffusion encoding directions within a reasonable total scan time. We accomplish this aim by implementing self-navigated, multishot, variable-density, spiral encoding with outer volume suppression. We establish scan protocols for achieving equal signal-to-noise ratio at 1.2 mm and 0.8 mm in-plane resolution for reduced field-of-view diffusion tensor imaging of the brainstem. In vivo application of the technique on the human pons of three subjects shows a clear delineation of the multiple local neural tracts. By comparing scans acquired with varying in-plane resolution but with constant signal-to-noise ratio, we demonstrate that increasing the resolution and reducing the partial volume effect result in higher fractional anisotropy values for the corticospinal tracts.

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“…To comprehensively probe corticomotor-cerebellar integrity in ataxic conditions, [21][22][23][24][25][26][27][28] diffusion tensor imaging (DTI), 29 a model of dMRI, is used. The diffusion tensor describes the molecular displacement (D) of water in the brain in three dimensions (x, y and z) and is comprised of a 3×3 matrix as shown:…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

“…127 These findings suggest that a threshold level of cerebellar degeneration may be a prerequisite to successful steroid therapy in A-T. 131,132 Such a threshold level may be determined using non-invasive imaging with MRI, especially diffusion-weighted imaging, which enable the extent of degeneration of cerebellar-corticomotor pathways to be quantitatively assessed in a number of ataxic conditions. [21][22][23][24][25][26][27][28] Interestingly, a recent fMRI pilot study where A-T patients received a 10-day cycle of oral betamethasone has shown increased activation within corticomotor regions after treatment using simple motor tasks. 133 This preliminary work suggests that steroid treatment could improve motor performance, facilitating cortical compensatory mechanisms.…”

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confidence: 99%

Investigating neural connectivity of corticomotor networks in ataxia telangiectasia: improving our understanding of the clinical phenotype

Sahama¹

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The human genetic disorder ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative condition occurring in 3 per million live births. The disease is characterised by neurodegeneration, immunodeficiency, radiosensitivity, cell cycle checkpoint defects, genomic instability and cancer predisposition among patients. The most debilitating aspect of the disease is progressive cerebellar ataxia, which represents the hallmark neuropathological condition of A-T.At present, long term therapy to cure or prevent progressive symptoms of A-T are not currently available. While short term treatment to alleviate symptoms associated with immunodeficiency and deficient lung function are available to patients, the predisposition to cancer and the progressive neurodegeneration associated with A-T cannot be prevented with such efforts. To gain a more informed understanding of the A-T condition, research has focused on clinical, genetic and immunological aspects of the disorder; however, minimal attention has been directed towards identifying altered brain structure and function using imaging modalities such as magnetic resonance imaging (MRI).Imaging studies in A-T are limited to structural MRI imaging, where various radiological anomalies in patients are reported as clinical case studies. While these studies provide a detailed focus on the morphological and histopathological conditions of A-T, they provide limited insight into the mechanisms of neurodegeneration and loss of neural motor network connectivity among patients. In other ataxic diseases such as Friedrich's ataxia and spinocerebellar ataxia, the use of high-resolution MRI and diffusion-weighted imaging (DWI) has given valuable insight into the microstructural tissue environment, and the loss of white matter integrity of motor networks due to abnormal neurodevelopmental and/or progressive neurodegenerative conditions associated with the disease.Such imaging approaches have not yet been extended to the study of A-T, and could provide important new information regarding the relationship between the ataxia-telangiectasia gene mutation (ATM) and loss of motor pathway integrity in A-T patients. ivThe key objective of this PhD programme was to investigate white matter integrity and grey matter volume changes associated with A-T using a combination of structural MRI and diffusion-weighted imaging, to pinpoint potential neurodegenerative biomarkers that can be targeted for therapeutic use among young A-T patients. Performing diffusion imaging in children with A-T presents a significant challenge, as spontaneous movement at resting positions form part of the A-T condition, and nonsedated imaging procedures will contribute to excessive motion artefact and limited image quality in diffusion-weighted images. To effectively detect and correct for motion artefacts, a series of data preprocessing and correction steps were introduced to the DWI processing pipeline of A-T images in this project. Whole brain imaging analysis, specifically voxel-based morphometry (based...

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Anatomical parcellation of the brainstem and cerebellar white matter: a preliminary probabilistic tractography study at 3 T

Cited by 125 publications

References 17 publications

Probabilistic Somatotopy of the Spinothalamic Pathway at the Ventroposterolateral Nucleus of the Thalamus in the Human Brain

Probabilistic Somatotopy of the Spinothalamic Pathway at the Ventroposterolateral Nucleus of the Thalamus in the Human Brain

High‐resolution diffusion tensor imaging of the human pons with a reduced field‐of‐view, multishot, variable‐density, spiral acquisition at 3 T

Investigating neural connectivity of corticomotor networks in ataxia telangiectasia: improving our understanding of the clinical phenotype

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