Anatomical Mapping of Lymphatic Drainage in Penile Carcinoma with SPECT-CT: Implications for the Extent of Inguinal Lymph Node Dissection

Leijte, Joost A.P.; Olmos, Renato A. Valdés; Nieweg, Omgo E.; Horenblas, Simon

doi:10.1016/j.eururo.2008.04.094

Cited by 122 publications

(47 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All SNs were located in the medial superior (73 %), lateral superior (8.7 %) and central (18.3 %) inguinal zones on SPECT/CT. No lymphatic drainage to the inferior zones of the groin was seen which suggests that it may be possible to exclude these zones from a subsequent inguinal lymph node dissection in the case of a tumour-positive SN [30]. Lymphatic drainage can be blocked by extensive metastatic involvement of the SN with rerouting of lymph fluid to a ''neo-SN''.…”

Section: Vulvar and Penile Cancermentioning

confidence: 98%

SPECT/CT and sentinel node lymphoscintigraphy

Olmos

Rietbergen

Vidal-Sicart

2014

Clin Transl Imaging

View full text Add to dashboard Cite

The use of single-photon emission computed tomography/computed tomography (SPECT/CT) for sentinel node (SN) detection has been evaluated in the majority of malignancies with predominantly superficial lymphatic drainage. In breast cancer and melanoma, important initial contributions of SPECT/CT were based on the anatomical localisation of SNs already visualised on planar images, the detection of additional SNs in aberrant basins, and the depiction of SNs in cases with no visualisation on planar images. However, more recently, the finding that SPECT/CT use is associated with a higher rate of SN detection, more metastatic SNs, and a higher rate of disease-free survival in large series of patients is leading SPECT/CT to be routinely performed in melanoma. The incorporation of SPECT/CT into the SN procedure in melanoma also appears to be cost effective and was significantly related to shorter operative times, shorter hospital stays, and fewer complications. In penile and vulvar cancer, the use of SPECT/CT has led to the detection of additional SNs. In oral cavity cancer and thyroid cancer, SPECT/CT not only appears to be useful for planar image interpretation but is also becoming an essential component of the SN procedure, providing surgeons with additional anatomical information. As regards malignancies with deep lymphatic drainage, SPECT/CT has been extensively validated in urological and gynaecological cancers. In these malignancies, SPECT/CT was able to localise SNs not only in the basins included in the area of extended pelvic lymph node dissection but also in aberrant locations. In gastrointestinal and lung malignancies, SPECT/CT has been used only incidentally. SPECT/CT must be considered complementary to planar lymphoscintigraphy for SN identification, and a combined interpretation of both modalities is necessary. With the improvement of the CT component, nuclear physicians today can also identify lymph nodes corresponding to radioactive SNs. This visual information is helpful for the intraoperative procedure and for postexcision assessment using portable devices.

show abstract

Section: Vulvar and Penile Cancermentioning

confidence: 98%

SPECT/CT and sentinel node lymphoscintigraphy

Olmos

Rietbergen

Vidal-Sicart

2014

Clin Transl Imaging

View full text Add to dashboard Cite

show abstract

“…29 Crossover drainage from the left to right groin or vice versa can also occur. 30 Pelvic LNs are the second regional nodal packet affected by lymphatic metastatic spread, and it typically occurs in the setting of ipsilateral ILN disease. 31 The pelvic LNs of interest include the obturator, external iliac, and internal iliac LNs where up to 12-20 nodes can be found.…”

Section: Surgical Treatment Of T2-t4 Diseasementioning

confidence: 99%

Current surgical management of penile cancer

Zargar‐Shoshtari¹,

Spiess²

2015

Current Problems in Cancer

View full text Add to dashboard Cite

“…An interesting study has recently been reported whereby hybrid single-photon emission CT lymphatic drainage patterns were analyzed in a cohort of patients. In 10%, the sentinel nodes were located in the lateral superior zone (based on Daseler's classification) which is not sampled with either modified dissection, providing a rationale for recurrences (67).…”

Section: Assessment Of the Inguinal Nodesmentioning

confidence: 99%

Update in the management of penile cancer

et al. 2009

View full text Add to dashboard Cite

Purpose: The management of penile cancer has evolved as less invasive techniques are applied in the treatment of the primary tumor and inguinal lymph nodes. Materials and Methods: Herein we review the literature focusing on advances in the preservation of the phallus as well as less morbid procedures to evaluate and treat the groins. Results: Promising imaging modalities for staging are discussed. New techniques are described and tables provided for penile preservation. We also review the contemporary morbidity of modified surgical forms for evaluation of the inguinal nodes. Conclusions: Advances in surgical technique have made phallic preservation possible in a greater number of primary penile cancers. The groins can be evaluated for metastasis with greater accuracy through new radiologic means as well as with less morbid modified surgical techniques.

show abstract

Anatomical Mapping of Lymphatic Drainage in Penile Carcinoma with SPECT-CT: Implications for the Extent of Inguinal Lymph Node Dissection

Cited by 122 publications

References 21 publications

SPECT/CT and sentinel node lymphoscintigraphy

SPECT/CT and sentinel node lymphoscintigraphy

Current surgical management of penile cancer

Update in the management of penile cancer

Contact Info

Product

Resources

About