Anatomical mapping of functional activation in stereotactic coordinate space

Evans, Alan C.; Marrett, Sean; Neelin, P.; Collins, D. Louis; Worsley, Keith J.; Dai, Weiqian; Milot, Sylvain; Meyer, Ernst; Bub, Daniel N.

doi:10.1016/1053-8119(92)90006-9

Cited by 390 publications

(222 citation statements)

References 17 publications

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“…PET images were reconstructed using a 6 mm fullwidth half-maximum Hanning filter. Each individual's weighted radioactivity PET images were coregistered to average MRI (Evans et al, 1992) derived from each subjects' high-resolution T1-weighted MRI. PET scans corrupted by movement were corrected by applying an algorithm that compensates for between-frame misalignment (Perruchot et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [¹¹C]Raclopride Study with Amphetamine

Boileau¹,

Dagher²,

Leyton³

et al. 2007

J. Neurosci.

206

101

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Studies in laboratory rodents suggest that previously neutral stimuli repeatedly paired with the administration of drugs of abuse can acquire the ability to increase striatal dopamine release. This conditioned neurochemical response is believed to prompt drug seeking in animals and has been hypothesized to contribute to drug craving and relapse in substance abusers. In the present study, we used positron emission tomography and 11 C]raclopride binding potential in the ventral striatum and did so with the same amplitude as amphetamine (23%). These results suggest that cues associated with amphetamine increase dopamine transmission, providing evidence that this system is involved in reward prediction in humans.

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Section: Methodsmentioning

confidence: 99%

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [¹¹C]Raclopride Study with Amphetamine

Boileau¹,

Dagher²,

Leyton³

et al. 2007

J. Neurosci.

206

101

View full text Add to dashboard Cite

show abstract

“…These volumes were corrected for image intensity nonuniformity , and linearly and nonlinearly transformed into standardized stereotaxic space (Talairach and Tournoux, 1988) using automated feature matching to the MNI305 template (Collins et al, 1994b;Collins and Evans, 1997). Each individual's MRI was then coregistered to their summed radioactivity PET images (Evans et al, 1992). Inspection of the time activity curves suggested that one subject moved during one scan.…”

Section: Methodsmentioning

confidence: 99%

Decreasing Amphetamine-Induced Dopamine Release by Acute Phenylalanine/Tyrosine Depletion: A PET/[11C]Raclopride Study in Healthy Men

Leyton

Dagher

Boileau

et al. 2003

Neuropsychopharmacol

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Acute phenylalanine/tyrosine depletion (APTD) has been proposed as a new method to decrease catecholamine neurotransmission safely, rapidly, and transiently. Validation studies in animals are encouraging, but direct evidence in human brain is lacking. In the present study, we tested the hypothesis that APTD would reduce stimulated dopamine (DA) release, as assessed by positron emission tomography (PET) and changes in [ 11 C]raclopride binding potential (BP), a measure of DA D2/D3 receptor availability. Eight healthy men received two PET scans, both following d-amphetamine, 0.3 mg/kg, p.o., an oral dose known to decrease [ 11 C]raclopride BP in ventral striatum. On the morning before each scan, subjects ingested, in counter-balanced order, an amino-acid mixture deficient in the catecholamine precursors, phenylalanine, and tyrosine, or a nutritionally balanced mixture. Brain parametric images were generated by calculating [ 11 C]raclopride BP at each voxel. BP values were extracted from the t-map (threshold: t ¼ 4.2, equivalent to po0.05, Bonferroni corrected) and a priori identified regions of interest from each individual's coregistered magnetic resonance images. Both receptor parametric mapping and region of interest analyses indicated that [ 11 C]raclopride binding was significantly different on the two test days in the ventral striatum (peak t ¼ 6.31; x ¼ À25, y ¼ À8, and z ¼ 0.1). In the t-map defined cluster, [ 11 C]raclopride BP values were 11.8 7 11.9% higher during the APTD session (po0.05). The reduction in d-amphetamine-induced DA release exhibited a linear association with the reduction in plasma tyrosine levels (r ¼ À0.82, po0.05). Together, the results provide the first direct evidence that APTD decreases stimulated DA release in human brain. APTD may be a suitable new tool for human neuropsychopharmacology research.

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“…High resolution (1 mm) T1-weighted magnetic resonance imaging (MRI) images were obtained for all subjects, co-registered to the summed radioactivity PET images (Evans et al 1992), and linearly transformed into standardized stereotaxic space (Talairach and Tournoux 1988) using automated algorithms (Collins et al 1994).…”

Section: Pet and Mrimentioning

confidence: 99%

Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking A PET/[11C]Raclopride Study in Healthy Men

Leyton

Boileau

Benkelfat

et al. 2002

Neuropsychopharmacology

421

211

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Anatomical mapping of functional activation in stereotactic coordinate space

Cited by 390 publications

References 17 publications

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [¹¹C]Raclopride Study with Amphetamine

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [¹¹C]Raclopride Study with Amphetamine

Decreasing Amphetamine-Induced Dopamine Release by Acute Phenylalanine/Tyrosine Depletion: A PET/[11C]Raclopride Study in Healthy Men

Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking A PET/[11C]Raclopride Study in Healthy Men

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Anatomical mapping of functional activation in stereotactic coordinate space

Cited by 390 publications

References 17 publications

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [11C]Raclopride Study with Amphetamine

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [11C]Raclopride Study with Amphetamine

Decreasing Amphetamine-Induced Dopamine Release by Acute Phenylalanine/Tyrosine Depletion: A PET/[11C]Raclopride Study in Healthy Men

Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking A PET/[11C]Raclopride Study in Healthy Men

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Conditioned Dopamine Release in Humans: A Positron Emission Tomography [¹¹C]Raclopride Study with Amphetamine

Conditioned Dopamine Release in Humans: A Positron Emission Tomography [¹¹C]Raclopride Study with Amphetamine