Anatomical location of the spinothalamic tract in the subcortical white matter in the human brain: A diffusion tensor imaging study

Jang, Sung Ho; Seo, Jeong Hyun

doi:10.1002/ca.23709

Cited by 6 publications

(5 citation statements)

References 25 publications

(43 reference statements)

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“… 21 However, in this study, the entire CST was not estimated like our study because the FA value was measured 2-dimensionally in the corona radiate, which contains other neural tracts such as the corticoreticular tract and spinothalamic tract as well as the CST. 32 , 33 In addition, their results were different with our results. As a result, to the best of our knowledge, the present study is the first to demonstrate a relation between the ipsilesional CST state and ADL independence, which was estimated the entire CST using DTT in patients with chronic ICH.…”

Section: Discussioncontrasting

confidence: 99%

Relation Between the Corticospinal Tract State and Activities of Daily Living in Patients With Intracerebral Hemorrhage

Jang

Choi

2022

Stroke

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Background and Purpose: We investigated the relation between the ipsilesional corticospinal tract (CST) state and activity of daily living independence in patients with chronic intracerebral hemorrhage. Methods: Fifty-six consecutive patients with unilateral intracerebral hemorrhage and 38 healthy control subjects were recruited for this study. The Motricity index and the modified Barthel index were used to evaluate motor function of the affected extremities and activity of daily living independence, respectively. The diffusion tensor imaging parameter values for fractional anisotropy (FA) and voxel number (VN) of the CST were determined. Ratios of the ipsilesional to the contralesional CST measures were calculated and are presented as the CST-ratio (FA value and VN). Results: The FA value and VN of the ipsilesional CST and the CST-ratio in the patient group were lower than those of the control group ( P <0.05). There was a strong positive correlation between the Motricity index score of the affected extremities and the modified Barthel index score ( P <0.05), while the FA value and VN of the ipsilesional CST and the CST-ratio showed moderate and strong positive correlations with the Motricity index and modified Barthel index scores, respectively ( P <0.05). In addition, the VN of the ipsilesional CST showed excellent utility as a classifier, whereas the FA value of the ipsilesional CST and the FA value and VN of the CST-ratio showed good classifier utility ( P <0.05). Conclusions: We demonstrated that impairment of activity of daily living independency was closely related to the injury severity of the ipsilesional CST in patients with chronic intracerebral hemorrhage. In addition, the injury severity of the ipsilesional CST can be used to classify the degree of activity of daily living independency. REGISTRATION: URL: http://www.e-irb.com/index.jsp ; Unique identifier: 2021-03-014.

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Section: Discussioncontrasting

confidence: 99%

Relation Between the Corticospinal Tract State and Activities of Daily Living in Patients With Intracerebral Hemorrhage

Jang

Choi

2022

Stroke

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“… 29 In the clinical application of DTI/DTT to visualize the STT in patients with CPSP, the STT and its thalamocortical pathway were observed from the medulla oblongata to the subcortical white matter. 30 , 31 Using imaging techniques in clinic settings, partial damage to the STT was observed, with preservation, rather than disruption, of the integrity of the fiber tract more likely leading to CPSP. 32 This is consistent with the concept proposed by Wasner et al that “the partially preserved STT acts as a central pain generator”.…”

Section: Resultsmentioning

confidence: 99%

Role of Sensory Pathway Injury in Central Post-Stroke Pain: A Narrative Review of Its Pathogenetic Mechanism

Li¹,

Lin²,

Tan³

et al. 2023

JPR

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Central post-stroke pain (CPSP) is a severe chronic neuropathic pain syndrome that is a direct result of cerebrovascular lesions affecting the central somatosensory system. The pathogenesis of this condition remains unclear owing to its extensive clinical manifestations. Nevertheless, clinical and animal experiments have allowed a comprehensive understanding of the mechanisms underlying CPSP occurrence, based on which different theoretical hypotheses have been proposed. We reviewed and collected the literature and on the mechanisms of CPSP by searching the English literature in PubMed and EMBASE databases for the period 2002–2022. Recent studies have reported that CPSP occurrence is mainly due to post-stroke nerve injury and microglial activation, with an inflammatory response leading to central sensitization and de-inhibition. In addition to the primary injury at the stroke site, peripheral nerves, spinal cord, and brain regions outside the stroke site are involved in the occurrence and development of CPSP. In the present study, we reviewed the mechanism of action of CPSP from both clinical studies and basic research based on its sensory pathway. Through this review, we hope to increase the understanding of the mechanism of CPSP.

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“…As one of the important components of fMRI, DTI can quantitatively analyze the diffusion movement of water molecules in tissues in three-dimensional space compared with DWI. Due to the anisotropic characteristics of water diffusion in tissues, it can show different tissue structures, which is of great significance in the study of white matter fiber bundles in the brain [8,9]. FA value and MD value, as two quantitative indexes of DTI, have been used many times in previous studies.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of cervical spine ZOOM-DWI in cervical spondylotic myelopathy

Li,

Tian,

Zhao

et al. 2024

Eur Spine J

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Purpose To investigate the clinical application value of the non-shared incentive diffusion imaging technique (ZOOM-DWI) diagnoses of cervical spondylotic myelopathy (CSM). Methods 49 CSM patients who presented from January 2022 to December 2022 were selected as the patient group, and 50 healthy volunteers are recruited as the control group. All subjects underwent conventional MRI and ZOOM-DWI of the cervical spine and neurologic mJOA scores in patients with CSM. The spinal ADC values of segments C2-3, C4-5, C5-6, and C6-7 are measured and analyzed in all subjects, with C5-6 being the most severe level of spinal canal compression in the patient group. In addition, the study also analyzes and compares the relationship between the C5-6 ADC value and mJOA score in the patient group. Results The mean ADC shows no significantly different levels in the control group. Among the ADC values at each measurement level in the patient group, except for C4-5 and C6-7 segments are not statistically significant, the remaining pair-wise comparisons all show statistically significant differences (F = 24.368, p < 0.001). And these individuals have the highest ADC value at C5-6. The C5-6 ADC value in the patient group is significantly higher compared with the ADC value in the control group (t = 9.414, p < 0.001), with statistical significance. The ADC value at the patient stenosis shows a significant negative correlation with the mJOA score (r = −0.493, p < 0.001). Conclusion Cervical ZOOM-DWI can be applied to diagnose CSM, and spinal ADC value can use as reliable imaging data for diagnosing cervical myelopathy.

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Anatomical location of the spinothalamic tract in the subcortical white matter in the human brain: A diffusion tensor imaging study

Cited by 6 publications

References 25 publications

Relation Between the Corticospinal Tract State and Activities of Daily Living in Patients With Intracerebral Hemorrhage

Relation Between the Corticospinal Tract State and Activities of Daily Living in Patients With Intracerebral Hemorrhage

Role of Sensory Pathway Injury in Central Post-Stroke Pain: A Narrative Review of Its Pathogenetic Mechanism

Diagnostic value of cervical spine ZOOM-DWI in cervical spondylotic myelopathy

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