Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions

Yamanaka, Takehiko; Uchida, Yuto; Sakurai, Keita; Kato, Daisuke; Mizuno, Masayuki; Sato, Toyohiro; Madokoro, Yuta; Kondô, Yûkô; Suzuki, Asuka; Ueki, Yoshino; Ishii, Fumiyasu; Borlongan, Cesar V.; Matsukawa, Noriyuki

doi:10.14336/ad.2018.0929

Cited by 15 publications

(13 citation statements)

References 36 publications

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“…PVWMH linked to atrophic processes was likely to affect the long association fibers that connected the more distant cortical areas. The study involving executive functions revealed the association between PVWMH and working memory, DWMH and inhibition performance, and MTA and flexibility performance (32). The relationship between WMH and attention and executive function was also demonstrated in our study.…”

Section: Discussionsupporting

confidence: 80%

The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment

Shen

Jia

et al. 2021

Front. Psychiatry

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Objectives: Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memory clinics.Methods: A total of 236 patients with MCI and 85 healthy controls were included. One hundred nine amnestic MCI-multiple domains (amMCI), 38 amnestic MCI-single domain (asMCI), 36 non-amnestic MCI-multiple domains (namMCI), and 53 non-amnestic MCI-single domain (nasMCI) patients were diagnosed. All participants were evaluated with the cognitive assessments and imaging features including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and cerebral atrophy according to a standard procedure.Results: The patients with amMCI, namMCI, and nasMCI had more high-grade basal ganglia EPVS compared with healthy controls, while the percentages of high-grade basal ganglia EPVS in the patients with amMCI were also more than those in patients with asMCI, namMCI, and nasMCI. There were more high-grade centrum semiovale EPVS in patients with amMCI in comparison with all other groups. The patients with amMCI and namMCI had more percentages of severe deep and periventricular WMH and deep CMBs compared with healthy controls. All MCI groups had higher scores of the medial temporal lobe atrophy than healthy controls, whereas the scores of the amMCI group were also higher than those of the namMCI and nasMCI groups.Conclusions: There were varied neuroimaging features of CSVD including cerebral atrophy in different MCI groups, which meant that vascular mechanism contributed to the prodromal stage of dementia.

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Section: Discussionsupporting

confidence: 80%

The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment

Shen

Jia

et al. 2021

Front. Psychiatry

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“…Currently, significant advances have been made in neuroimaging modalities in neurodegenerative disease 12,27–29 . Neuroimaging on cognitive impairment has become a research hotspot in PD, providing in vivo insights into examining the structural and biochemical changes in PD 23,30–39 . However, no reliable predictors of cognitive impairment exist in PD so far.…”

Section: Introductionmentioning

confidence: 99%

The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease

Liu

Deng

Xie

et al. 2021

Ann Clin Transl Neurol

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The aim of this meta‐analysis was to review systematically and to identify the relationship between the severity and location of white matter hyperintensities (WMHs) and the degree of cognitive decline in patients with Parkinson’s disease (PD). We searched the PubMed, EMBASE, Web of Science, Ovid, and Cochrane Library databases for clinical trials of the severity and location of WMHs on the degree of cognitive impairment in PD through October 2020. We conducted the survey to compare the association of WMH burden in patients with PD with mild cognitive impairment (PD‐MCI) versus those with normal cognition (PD‐NC) and in patients with PD with dementia (PDD) versus those with PD without dementia (PD‐ND). Nine studies with PD‐MCI versus PD‐NC and 10 studies with PDD versus PD‐ND comparisons were included. The WMH burden in PD‐MCI patients was significantly different compared to that in PD‐NC patients (standard mean difference, SMD = 0.39, 95% CI: 0.12 to 0.66, p = 0.005), while there was no correlation shown in the age‐matched subgroup of the comparison. In addition, PDD patients had a significantly higher burden of WMHs (SMD = 0.8, 95% CI: 0.44 to 1.71, p < 0.0001), especially deep white matter hyperintensities (SMD = 0.54, 95% CI: 0.36 to 0.73, p < 0.00001) and periventricular hyperintensities (SMD = 0.70, 95% CI: 0.36 to 1.04, p < 0.0001), than PD‐NC patients, regardless of the adjustment of age. WMHs might be imaging markers for cognitive impairment in PDD but not in PD‐MCI, regardless of age, vascular risk factors, or race. Further prospective studies are needed to validate the conclusions.

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“…Moreover, there is growing evidence that the WMHs is imperative to cognitive dysfunction, particularly in executive function. Niels et al reported that increasing severity of periventricular WMHs was specifically associated with impaired information processing speed and executive function ( Prins et al, 2005 ; Smith et al, 2011 ; Yamanaka et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities

Cao

Nie

Zhang

et al. 2021

Front. Aging Neurosci.

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ObjectiveWhite matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is frequently presumed to be secondary to cerebral small vessel disease (CSVD) and associated with cognitive decline. The cerebellum plays a key role in cognition and has dense connections with other brain regions. Thus, the aim of this study was to investigate if cerebellar abnormalities could occur in CSVD patients with WMHs and the possible association with cognitive performances.MethodsA total of 104 right-handed patients with WMHs were divided into the mild WMHs group (n = 39), moderate WMHs group (n = 37), and severe WMHs group (n = 28) according to the Fazekas scale, and 36 healthy controls were matched for sex ratio, age, education years, and acquired resting-state functional MRI. Analysis of voxel-based morphometry of gray matter volume (GMV) and seed-to-whole-brain functional connectivity (FC) was performed from the perspective of the cerebellum, and their correlations with neuropsychological variables were explored.ResultsThe analysis revealed a lower GMV in the bilateral cerebellum lobule VI and decreased FC between the left- and right-sided cerebellar lobule VI with the left anterior cingulate gyri in CSVD patients with WMHs. Both changes in structure and function were correlated with cognitive impairment in patients with WMHs.ConclusionOur study revealed damaged GMV and FC in the cerebellum associated with cognitive impairment. This indicates that the cerebellum may play a key role in the modulation of cognitive function in CSVD patients with WMHs.

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Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions

Cited by 15 publications

References 36 publications

The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment

The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment

The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease

The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities

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