“…Furthermore, the cellular and molecular effects of the mechanical signals through this interface have been shown to be widespread, varying from cell contraction to signal transduction to gene expression (Langevin et al, 2002). Fascia has been reported to have the following functions: (1) it provides a 3D framework for all tissues promoting alignment and stability (DeRosa and Porterfield, 2007), (2) it can respond to change in tension levels by transmission of signals to other interfaces (Langevin, 2006;Stecco et al, 2009), termed 'mechanotransduction', and (3) it provides the necessary lubricant between tissue interfaces to enable movement (Alter, 2004). Research by Hinz and Gabbiani (2007), Schleip et al (2006Schleip et al ( , 2007, Petroll (2008) and Thomasek et al (2002) have reported a fourth function, that fascia is capable of generating its own mechanical tension through the contraction of smooth muscle cells within its matrix.…”