Anatomical factors in medication-related osteonecrosis of the jaws

Abstract

Introduction: Medication-related osteonecrosis of the jaws (MRONJ) is a serious adverse event of antiresorptive and antiangiogenic drugs that affects bone and soft tissue of the maxilofacial region [1]. Clinical features and risk factors of MRONJ have been described in several publications, however few studies address the anatomical factors involved [2,3]. This study aims to: (a) describe in detail the anatomical location of MRONJ lesions; (b) identify the most susceptible areas and association with other factors. Materials and methods: A retrospective study was conducted including all patients with MRONJ diagnosis in an Oral Surgery Clinic between 2004 and 2018. The data was collected from the patient clinical records. Lesion extension was S86 ABSTRACTS