Anatomical Effects of Thiouracil

Pharmacology

“…Edema of the lungs frequently occurs, but not always. There is a marked retardation of grow�h, and signs of cretinism appear if medication is instituted at the time of birth (235,236). Continued administration of thiouracil to rats induces leucopenia and anemia (236).…”

The Influence of Thiouracil on Semen Quality in the Fowl ,

“…Leathern (1946) reported that 0.1 percent thiourea in the diet of rats for twenty days decreased seminal vesicle size. Williams et al (1944) studied the effects of 0.25 percent thiouracil in the drinking water of rats for fourteen days. No change was observed in the size or microscopic appearance of the testes or ovaries.…”

The Influence of Thiouracil on Reproduction and Growth in the Rat

“…Hughes [1944], Goldsmith et al. [1944] and Freiesleben & Kjerulf-Jensen [1946, 1947 also confirm the findings of Williams, Kay & Jandorf [1944] and Williams, Weinglass, Bissell & Peters [1944] that these drugs are secreted into the milk by the mammary glands in the rat and the human. Thus, characteristic effects on the thyroid glands and interference with growth at the early stages of development are produced by these thyroid-inhibiting drugs.…”

“…Protein-bound iodine (PI) was measured by the method described by Barker [1948] ; this type of determination has been shown by many to determine the status of thyroid function [cf. Salter, Bassett & Sappington, 1941 ;Lowenstein, Bruger & Hinton, 1944;Taurog, Chaikoff & Bennett, 1946;and Wolff, Chaikoff, Taurog & Rubin, 1946].…”