Anatomical and psychometric relationships of behavioral neglect in daily living

Rousseaux, M.; Allart, Étienne; Bernati, T.; Saj̈, Arnaud

doi:10.1016/j.neuropsychologia.2015.02.011

Cited by 33 publications

(43 citation statements)

References 42 publications

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“…Studies indicate that there are regions of the brain that are associated with different types of anosognosia (Pia, Neppi-Modona, Ricci, & Berti, 2004; Rousseaux, Allart, Bernati, & Saj, 2015; Starkstein et al, 2010; Vocat, Staub, Stroppini, & Vuilleumier, 2010; Vossel et al, 2012). Neuroanatomical relationships to neglect subtypes (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Examining Anosognosia of Neglect

Grattan

Skidmore

Woodbury

2017

OTJR: Occupation, Participation and Health

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Background Unilateral neglect (neglect) and anosognosia often co-occur post-stroke. It is unknown whether anosognosia of neglect varies for different types of daily activities. Objectives To examine the frequency of anosognosia of neglect for items on the Catherine Bergego Scale (CBS) and determine the level of agreement between participant/assessor item ratings and total scores. Methods Secondary analysis of data. We conducted descriptive analyses and inter-rater reliability analyses (Cohen’s kappa) to determine the level of agreement between assessor and participant item ratings. A paired t-test was conducted to compare assessor and participant total scores. Results The frequency of anosognosia amongst items varied (29.2%-83.3%), and Kappa statistics ranged from −0.07 (no agreement) to 0.23 (fair agreement) for item ratings. There was a significant difference t(36) =3.02, p≤.01) between assessor (M=8.0, SD= 5.2) and participant-rated (M=5.3, SD=4.5) total CBS scores. Conclusion Anosognosia is prevalent among those with neglect. Findings highlight the importance of assessing for anosognosia.

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Section: Discussionmentioning

confidence: 99%

“…Neuroanatomical relationships to neglect subtypes (e.g. personal, peripersonal) have also been identified (Corbetta & Shulman, 2011; Rousseaux et al, 2015). It is possible that neuroanatomical correlates exist for different subtypes of anosognosia of neglect as well.…”

Section: Discussionmentioning

confidence: 99%

Examining Anosognosia of Neglect

Grattan

Skidmore

Woodbury

2017

OTJR: Occupation, Participation and Health

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“…Heterogeneous findings were observed, causing lively controversies (for review Karnath and Rorden, 2012). In the right hemisphere, spatial neglect has been reported to be associated with parietal lesions to the inferior parietal lobule and temporo-parietal junction (Chechlacz et al, 2010;Karnath et al, 2011;Rousseaux et al, 2015), the superior and middle temporal cortex as well as the insula (Karnath et al, 2004Committeri et al, 2007;Sarri et al, 2009;Chechlacz et al, 2010;Saj et al, 2012;Rousseaux et al, 2015) and the ventrolateral prefrontal cortex (Committeri et al, 2007;Thiebaut De Schotten et al, 2014). These cortical areas were also found to be involved in the human left hemisphere when patients show spatial neglect after a left hemisphere stroke (Suchan and Karnath, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…These might have contributed to the heterogeneous results of previous lesion-symptom mapping investigations in spatial neglect using mass-univariate VLBM (Karnath et al, 2004Committeri et al, 2007;Sarri et al, 2009;Chechlacz et al, 2010;Saj et al, 2012;Thiebaut De Schotten et al, 2014;Rousseaux et al, 2015) and DTI/white matter fiber analyses (Thiebaut De Schotten et al, 2005;Urbanski et al, 2008Urbanski et al, , 2011Karnath et al, 2009;Shinoura et al, 2009;Ciaraffa et al, 2013;Thiebaut De Schotten et al, 2014;Umarova et al, 2014;Lunven et al, 2015;Vaessen et al, 2016;Carter et al, 2017). While using meta-analytic approaches combining various VLBM results, one might be able to find all critical parts of the presumed network.…”

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confidence: 99%

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Using machine learning-based lesion behavior mapping to identify anatomical networks of cognitive dysfunction: spatial neglect and attention

Wiesen

Sperber

Yourganov

et al. 2019

Preprint

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Previous lesion behavior studies primarily used univariate lesion behavior mapping techniques to map the anatomical basis of spatial neglect after right brain damage. These studies led to inconsistent results and lively controversies. Given these inconsistencies, the idea of a widespread network that might underlie spatial orientation and neglect has been pushed forward. In such case, univariate lesion behavior mapping methods might have been inherently limited in uncover the presumed network in a single study due to limited statistical power. By using multivariate lesion-mapping based on support vector regression, we aimed to validate the network hypothesis directly in a large sample of 203 newly recruited right brain damaged patients. In a single analysis, this method identified a network of parietal, temporal, frontal, and subcortical regions, which also included white matter tracts connecting these regions. The results were compared to univariate analyses of the same patient sample using different combinations of lesion volume correction and statistical thresholding. The comparison revealed clear benefits of multivariate lesion behavior mapping in identifying brain networks. KeywordsStroke; spatial attention; support vector regression; VLSM; voxel-based lesion behavior mapping; multivariate Abbreviations VLBM -Voxel-based lesion behavior mapping; MLBM -Multivariate lesion behavior mapping; SVR -Support vector regression; SVR-LSM -Support vector regression based lesionsymptom mapping; FDR -false discovery rate; FWE -Family Wise Error; dTLVC -Direct Total Lesion Volume Control

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Disconnections in personal neglect

et al. 2022

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Personal neglect is a disorder in the perception and representation of the body that causes the patients to behave as if the contralesional side of their body does not exist. This clinical condition has not been adequately investigated in the past as it has been considered a symptom of unilateral spatial neglect, which has mainly been studied with reference to extrapersonal space. Only a few studies with small samples have investigated the neuroanatomical correlates of personal neglect, and these have mainly focused on discrete cortical lesions and modular accounts, as well as being based on the hypothesis that this disorder is associated with somatosensory and spatial deficits. In the present study, we tested the novel hypothesis that personal neglect may be associated not only with discrete cortical and subcortical lesions, but also with disconnections of white matter tracts. We performed an advanced lesion analyses in a large sample of 104 right hemisphere damaged patients, 72 of whom were suffering from personal neglect. Results from the analyses of the grey and white matter were controlled for co-occurrent clinical variables such as extrapersonal neglect, anosognosia for hemiplegia and motor deficits, along with other lesion-related variables such as lesion size and the interval from the lesion onset to neuroimaging recordings. Our results reveal that personal neglect is associated with lesions in a medial network which involves the temporal cortex (Heschl’s gyrus), the ventro-lateral nuclei of the thalamus and the fornix. This suggests that personal neglect involves a convergence between sensorimotor processes, spatial representation and the processing of self-referred information (episodic memory).

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Anatomical and psychometric relationships of behavioral neglect in daily living

Cited by 33 publications

References 42 publications

Examining Anosognosia of Neglect

Examining Anosognosia of Neglect

Using machine learning-based lesion behavior mapping to identify anatomical networks of cognitive dysfunction: spatial neglect and attention

Disconnections in personal neglect

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