Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat

Hammond, Constance; Rouzaire-Dubois, B.; Féger, J.; Jackson, A.; Crossman, Alan R.

doi:10.1016/0306-4522(83)90045-3

Cited by 183 publications

(91 citation statements)

References 22 publications

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“…In contrast to those findings, other reports in rodents [2] and primates [3] have demonstrated that nucleus subthalamicus (STN) projections to the PPN were exclusively ipsilateral. …”

Section: Rationales For Bilateral Versus Unilateral Ppn Dbscontrasting

confidence: 50%

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Techniques, Side Effects, and Postoperative Imaging

Hamani

Lozano

Mazzone

et al. 2016

Stereotact Funct Neurosurg

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The pedunculopontine nucleus (PPN) region has received considerable attention in clinical studies as a target for deep brain stimulation (DBS) in Parkinson disease. These studies have yielded variable results with an overall impression of improvement in falls and freezing in many but not all patients treated. We evaluated the available data on the surgical anatomy and terminology of the PPN region in a companion paper. Here we focus on issues concerning surgical technique, imaging, and early side effects of surgery. The aim of this paper was to gain more insight into the reasoning for choosing specific techniques and to discuss shortcomings of available studies. Our data demonstrate the wide range in almost all fields which were investigated. There are a number of important challenges to be resolved, such as identification of the optimal target, the choice of the surgical approach to optimize electrode placement, the impact on the outcome of specific surgical techniques, the reliability of intraoperative confirmation of the target, and methodological differences in postoperative validation of the electrode position. There is considerable variability both within and across groups, the overall experience with PPN DBS is still limited, and there is a lack of controlled trials. Despite these challenges, the procedure seems to provide benefit to selected patients and appears to be relatively safe. One important limitation in comparing studies from different centers and analyzing outcomes is the great variability in targeting and surgical techniques, as shown in our paper. The challenges we identified will be of relevance when designing future studies to better address several controversial issues. We hope that the data we accumulated may facilitate the development of surgical protocols for PPN DBS.

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“…In contrast to those findings, other reports in rodents [2] and primates [3] have demonstrated that nucleus subthalamicus (STN) projections to the PPN were exclusively ipsilateral. …”

Section: Rationales For Bilateral Versus Unilateral Ppn Dbscontrasting

confidence: 50%

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Techniques, Side Effects, and Postoperative Imaging

Hamani

Lozano

Mazzone

et al. 2016

Stereotact Funct Neurosurg

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“…1). In the rat the neurons of STN are characterized by an important dendritic field around the cell bodies, thus suggesting that excitatory recurrent collaterals could represent the element of circuitry subserving the synchronization of closely spatially related neurons (Hammond et al, 1983). Strong synchronization in STN cell firing could also modify propagation of signals from the neocortex to the output BG nuclei.…”

Section: Discussionmentioning

confidence: 99%

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

Lintas¹,

Силькис²,

Albèri³

et al. 2012

Brain Research

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Abnormal neuronal activity in the subthalamic nucleus (STN) plays a crucial role in the pathophysiology of Parkinson's disease (PD). In this study we investigated changes in rat STN neuronal activity after 28 days following the injection of 6-OHDA in the substantia nigra pars compacta (SNc). This drug provoked a lesion of SNc that induced a dopamine and lesioned (n = 83) groups was similar, as well as the firing rate. In 6-OHDA treated rats we observed a significant increase (from 26% to 48%) in the number of pairs with synchronous firing. These data suggest that the synchronous activity of STN cells, provoked by loss of DA cells in SNc, is likely to be among the most significant dysfunctions in the basal ganglia of Parkinsonian patients. We raise the hypothesis that in normal conditions, DA maintains a balance between funneling information via the hyperdirect cortico-subthalamic pathway and parallel processing through the parallel cortico-basal ganglia-subthalamic pathways, both of which are necessary for selected motor behaviors..

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“…Furthermorc, ascending DA projections from the VTA to the NA are important for the reinforcing effects of drugs (Koob and Bloom, 1988) as weIl as the analgesic effects of morphine (Morgan and , amphetamine (Morgan and Franklin, 1991), and cocaine (Lin et al, 1989: Pertovaara et al, 1988 Graybiel, 1983: Beninato andSpencer, 1987;Clarke et al, 1987), subthalamic nuclei (Hammond et al, 1983: Hallanger et al, 1987 t globus pallidus, and neostriatum (Saper and Lowey, 1982;Jackson and Crossrnan, 1983;Spann and Grofova, 1989), as weIl as descending projections to the deep cerebellar nuclei 17 (Dellovade et al, 1988;Newman and Ginsberg 1 1988), the nucleus reticularis gigantocellularis in the region of the medioventral medulla Rye et al, 1987;Spann and Grofova, 1989), the pontomedullary reticular nuclei (Rye et al, 1988), and the spinal cord (Goldsmith and van der Kooy, 1988;Rye et al, 1988;Spann and Grofova, 1989). Based on these observations Graybiel and Ragsdale (1978) and Alexander and Crutcher (1990) propose that the PPTg is one of the subsidiary basal ganglia circuits.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test

Olmstead

Franklin

1993

Neuroscience

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Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat

Cited by 183 publications

References 22 publications

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Techniques, Side Effects, and Postoperative Imaging

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Techniques, Side Effects, and Postoperative Imaging

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test

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