Aim: The incidence of shoulder replacement surgery has increased significantly in the past 10 years, becoming the 3rd most performed total joint arthroplasty after hip and knee and is expected to continue to rise with the increase in the active senior population of the United States. This case study describes rehabilitation following total shoulder arthroplasty (TSA) using a combination of traditional intervention and Total Motion Release (TMR) techniques. TMR is an intervention technique based on the concept of contralateral movement to affect fascial glide and neuromuscular dysfuntion. Case description: The patient was a 71-year old female who underwent a total shoulder replacement for treatment of significant osteoarthritis. Initially she presented with significant pain, loss of strength, range of motion (ROM) and function. Intervention: Traditional therapeutic exercise and manual therapy was combined with TMR techniques, including contralateral arm raise, straight leg raise and spine twist, to control pain and allow the patient earlier achievement of shoulder ROM. Outcome: Subjective report included decreased pain and improved function assessed with the QuickDASH, as well as satisfaction with the rapidity of recovery. Improved passive range of motion (PROM), active range of motion (AROM), posture and strength was also recorded at discharge. Discussion: A combination of traditional intervention and TMR techniques were successful in controlling pain early in rehabilitation, as well as restoring function and ROM. This case study supports the use of TMR during TSA rehabilitation.