Anatomic Study of the Quadrigeminal Cistern in Patients With 3-Dimensional Magnetic Resonance Cisternography

Columbano, Laura; Stieglitz, Lennart; Wrede, Karsten H.; Samii, Amir; Samii, Madjid; Luedemann, Wolf

doi:10.1227/01.neu.0000368384.06288.4c

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…The inferior colliculi may be especially vulnerable to rapid thiamine depletion, as may occur in the sequalae of parenteral hyperalimentation (Vortmeyer et al, 1992;Kishimoto et al, 2012). MRI studies occasionally report overt pathology involving the quadrigeminal plate such as the presence of cancer or cysts (e.g., Mancuso et al, 1988;Weindling et al, 1988;Herrmann et al, 1992;Fischer et al, 1994;Ono et al, 1998), but quantitative volumetric measures of the quadrigeminal plate are scarce (cf., Aiba et al, 1997;Angeles Fernandez-Gil et al, 2010;Columbano et al, 2010). To our knowledge, MRI-based inferior colliculi volume in WKS has not been reported.…”

Section: Thiamine Deficiency: Wernicke-korsakoff Syndrome (Wks)mentioning

confidence: 87%

The Inferior Colliculus in Alcoholism and Beyond

Bordia

Zahr

2020

Front. Syst. Neurosci.

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Post-mortem neuropathological and in vivo neuroimaging methods have demonstrated the vulnerability of the inferior colliculus to the sequelae of thiamine deficiency as occurs in Wernicke-Korsakoff Syndrome (WKS). A rich literature in animal models ranging from mice to monkeys—including our neuroimaging studies in rats—has shown involvement of the inferior colliculi in the neural response to thiamine depletion, frequently accomplished with pyrithiamine, an inhibitor of thiamine metabolism. In uncomplicated alcoholism (i.e., absent diagnosable neurological concomitants), the literature citing involvement of the inferior colliculus is scarce, has nearly all been accomplished in preclinical models, and is predominately discussed in the context of ethanol withdrawal. Our recent work using novel, voxel-based analysis of structural Magnetic Resonance Imaging (MRI) has demonstrated significant, persistent shrinkage of the inferior colliculus using acute and chronic ethanol exposure paradigms in two strains of rats. We speculate that these consistent findings should be considered from the perspective of the inferior colliculi having a relatively high CNS metabolic rate. As such, they are especially vulnerable to hypoxic injury and may be provide a common anatomical link among a variety of disparate insults. An argument will be made that the inferior colliculi have functions, possibly related to auditory gating, necessary for awareness of the external environment. Multimodal imaging including diffusion methods to provide more accurate in vivo visualization and quantification of the inferior colliculi may clarify the roles of brain stem nuclei such as the inferior colliculi in alcoholism and other neuropathologies marked by altered metabolism.

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Section: Thiamine Deficiency: Wernicke-korsakoff Syndrome (Wks)mentioning

confidence: 87%

The Inferior Colliculus in Alcoholism and Beyond

Bordia

Zahr

2020

Front. Syst. Neurosci.

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“…and Juarez-Jimenez, 2014). While MRI studies occasionally report overt pathology involving the quadrigeminal plate such as the presence of cancer or cysts (e.g., Ono et al, 1998;Weindling et al, 1988), quantitative volumetric measures of the quadrigeminal plate are scarce (cf., Columbano et al, 2010). To our knowledge, only 2 studies provide evidence for effects of AUD on the quadrigeminal plate.…”

Section: Discussionmentioning

confidence: 98%

“…EtOH‐induced molecular alterations have been noted in the superior colliculi (Booker and Collins, 1997; Hetzler et al, 1981) that may underlie psychomotor hyperactivity (Kleinert‐Altamirano and Juarez‐Jimenez, 2014). While MRI studies occasionally report overt pathology involving the quadrigeminal plate such as the presence of cancer or cysts (e.g., Ono et al, 1998; Weindling et al, 1988), quantitative volumetric measures of the quadrigeminal plate are scarce (cf., Columbano et al, 2010). To our knowledge, only 2 studies provide evidence for effects of AUD on the quadrigeminal plate.…”

Section: Discussionmentioning

confidence: 98%

Jacobian Mapping Reveals Converging Brain Substrates of Disruption and Repair in Response to Ethanol Exposure and Abstinence in 2 Strains of Rats

Zhao

Pohl

Sullivan

et al. 2020

Alcoholism Clin & Exp Res

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Background In a previous study using Jacobian mapping to evaluate the morphological effects on the brain of binge (4‐day) intragastric ethanol (EtOH) on wild‐type Wistar rats, we reported reversible thalamic shrinkage and lateral ventricular enlargement, but persistent superior and inferior colliculi shrinkage in response to binge EtOH treatment. Methods Herein, we used similar voxel‐based comparisons of Magnetic Resonance Images collected in EtOH‐exposed relative to control animals to test the hypothesis that regardless of the intoxication protocol or the rat strain, the hippocampi, thalami, and colliculi would be affected. Results Two experiments [binge (4‐day) intragastric EtOH in Fisher 344 rats and chronic (1‐month) vaporized EtOH in Wistar rats] showed similarly affected brain regions including retrosplenial and cingulate cortices, dorsal hippocampi, central and ventroposterior thalami, superior and inferior colliculi, periaqueductal gray, and corpus callosum. While most of these regions showed significant recovery, volumes of the colliculi and periaqueductal gray continued to show response to each proximal EtOH exposure but at diminished levels with repeated cycles. Conclusions Given the high metabolic rate of these enduringly affected regions, the current findings suggest that EtOH per se may affect cellular respiration leading to brain volume deficits. Further, responsivity greatly diminished likely reflecting neuroadaptation to repeated alcohol exposure. In summary, this unbiased, in vivo‐based approach demonstrating convergent brain systems responsive to 2 EtOH exposure protocols in 2 rat strains highlights regions that warrant further investigation in both animal models of alcoholism and in humans with alcohol use disorder.

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“…Various intracranial structures forming the supracollicular region were assessed on the basis of major anatomy books . The quadrigeminal cistern boundaries interpretation was based on human imaging anatomy works and previous reports in veterinary literature …”

Section: Methodsmentioning

confidence: 99%

“…I n the human anatomical literature, the term “quadrigeminal cistern” (also named cisterna quadrigeminalis or cisterna venae magnae cerebri ) refers to the subarachnoid space located between the splenium of the corpus callosum and the upper portion of the cerebellum . The quadrigeminal cistern of the dog is mentioned in the major anatomy books, but is not reported in the Nomina Anatomica Veterinaria (NAV) and there are no published anatomical studies describing this structure to date.…”

Section: Introductionmentioning

confidence: 99%

Multidetector Computed Tomographic and Low‐field Magnetic Resonance Imaging Anatomy of the Quadrigeminal Cistern and Characterization of Supracollicular Fluid Accumulations in Dogs

Bertolini

Ricciardi²,

Caldín³

2016

Vet Radiology Ultrasound

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Focal fluid accumulations in the supracollicular region are commonly termed quadrigeminal cysts and may be either subclinical or associated with neurologic deficits in dogs. Little published information is available on normal imaging anatomy and anatomic relationships for the canine quadrigeminal cistern. Objectives of this observational, cross-sectional study were to describe normal quadrigeminal cistern anatomy and determine the prevalence and characteristics of supracollicular fluid accumulations in dogs. Normal descriptions were accomplished using computed tomographic (CT) cisternography in one canine cadaver, and CT and magnetic resonance imaging (MRI) studies of the brain in four prospectively recruited dogs with no evidence of intracranial disease. Prevalence and characteristics descriptions were accomplished using a retrospective review of brain CT or MRI studies performed during the period of 2005-2015. The normal quadrigeminal cistern consistently exhibited a complex H shape and was separated from the third ventricle by a thin membrane. Prevalence of supracollicular fluid accumulations (SFAs) was 2.19% among CT studies (n = 4427) and 2.2% among MRI studies (n = 626). Dogs with SFA were significantly younger than control dogs (P < 0.0001). Shih-tzu (OR = 111.6), Chihuahua (OR = 81.1), and Maltese (OR = 27.6) breed dogs were predisposed (P < 0.0001). Among dogs with SFAs, the following three patterns were defined: (1) third ventricle (49.54%), (2) quadrigeminal cistern (13.51%), and (3) both third ventricle and quadrigeminal cistern (36.93%). Authors recommend that the term supracollicular fluid accumulation (SFA) should be used rather than the term quadrigeminal cyst to describe these focal fluid accumulations in dogs.

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Anatomic Study of the Quadrigeminal Cistern in Patients With 3-Dimensional Magnetic Resonance Cisternography

Cited by 7 publications

References 31 publications

The Inferior Colliculus in Alcoholism and Beyond

The Inferior Colliculus in Alcoholism and Beyond

Jacobian Mapping Reveals Converging Brain Substrates of Disruption and Repair in Response to Ethanol Exposure and Abstinence in 2 Strains of Rats

Multidetector Computed Tomographic and Low‐field Magnetic Resonance Imaging Anatomy of the Quadrigeminal Cistern and Characterization of Supracollicular Fluid Accumulations in Dogs

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