Anatomic Study of the Corneal Thickness of Young Emmetropic Subjects

Sanchis‐Gimeno, Juan A.; Lleó-Pérez, A.; Alonso, Luis Martı́nez; Rahhal, M.S.; Martı́nez-Soriano, Francisco

doi:10.1097/01.ico.0000126323.20767.89

Cited by 25 publications

(18 citation statements)

References 32 publications

(45 reference statements)

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“…In the current study, the potential effect of magnification on ECD was accounted for by the NAVIS software, which contains an internal calibration for magnification. 14 CCT measurement in this study (529 mm) was slightly less than that reported by Sanchis-Gimeno et al 30 (554 ± 16 mm), who studied the corneal thickness of 1000 young (range 20-30 years) emmetropic subjects using a similar Orbscan II slit-scanning corneal topography system. Comparison of CCT with other published reports is limited due to differences in measurement technique.…”

Section: Discussioncontrasting

confidence: 67%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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Purpose Despite the importance of a healthy endothelial layer in anterior segment surgery, the possible influence of corneal parameters on endothelial cell density (ECD) has largely been ignored in the young adult eye. This study investigated the possible associations between corneal tomographic parameters and ECD values in young adults. Methods Subjects aged 21-30 years, with normal corneas were recruited. Mean ECD, mean cell area (MCA), coefficient of variation for cell area (COVA), and proportion of hexagonal cells were derived by in vivo confocal microscopy. The Orbscan II system was used to measure corneal parameters including: thickness, horizontal corneal diameter, corneal curvature, anterior and posterior elevation, and eccentricity. Results Sixty-two subjects (42 female, 20 male) were included (mean age 25±3 years). Overall mean ECD was 3169±309 cells/mm 2 with no differences between genders. Mean percentage of hexagonality was 53 ± 5%, male subjects (55%) had a higher percentage of hexagonal cells than female subjects (51%) (P ¼ 0.02). Central corneal thickness (CCT) was 529±43 lm. Central ECD was significantly correlated with CCT (Pearson's r ¼ 0.26, P ¼ 0.04). However, horizontal corneal diameter (r ¼ 0.19, P ¼ 0.14), anterior corneal curvature (r ¼ À0.07, P ¼ 0.6), and posterior corneal curvature (r ¼ À0.07, P ¼ 0.6) were not correlated with ECD or percentage of hexagonality. There was no statistically significant association between anterior chamber depth (3.6±0.3 mm) and ECD (r ¼ 0.15, P ¼ 0.3). Conclusion Corneal thickness is related to ECD in normal young adult eye, with lower ECD values identified in thinner corneas; however, corneal diameter and corneal curvature do not have a significant correlation with ECD.

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Section: Discussioncontrasting

confidence: 67%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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“…However, during ultrasound pachymetry the physician must place the ultrasonic probe subjectively over the ocular surface taking the center of the pupil as a reference point, and the pressure when placing the probe on the ocular surface must be very delicate. 1 Moreover, this process requires topical anesthesia, which can modify CCT values. 2 Noncontact techniques, such as scanning-slit corneal topography (SSCT) and noncontact specular microscopy (NCSM), avoid the disadvantages of contact ultrasound pachymetry.…”

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confidence: 99%

Quantitative Anatomical Differences in Central Corneal Thickness Values Determined With Scanning-Slit Corneal Topography and Noncontact Specular Microscopy

Sanchis‐Gimeno

Herrera²,

Lleó-Pérez³

et al. 2006

Cornea

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“…Currently, there is a lack of information on the emmetropic CCT values over a lifetime because CCT studies are usually not performed on these eyes [2]. Previous studies carried out on emmetropic subjects have not analyzed the effect of age in CCT values [2]. Nevertheless, studies carried out on non-emmetropic eyes have detected contradictory results when analyzing the CCT values depending on the age of the subjects [3,4].…”

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

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Caucasian Emmetropic Aged Subjects have Reduced Corneal Thickness Values

Sanchis‐Gimeno

Lleó-Pérez²,

Alonso³

et al. 2004

Int Ophthalmol

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We aimed to analyze the possible changes in corneal thickness values according to age in emmetropic subjects. The central corneal thickness values of 100 emmetropic subjects (n = 100) were analyzed with the DGH 2000 AP ultrasonic pachymeter (DGH Technology, Inc., San Diego, CA, USA) by one experienced physician. The mean age of the subjects was 40.6 +/- 12.1 years old (range, 21-64). Analysis of the central corneal thickness (CCT) values by age subgroups indicated that subjects aged between 20 and 30 years had the higher CCT values. Differences in CCT values between the age groups were significant (p < 0.001; 1-way ANOVA test). A significant correlation between CCT values and age was found (r = -0.974; p < 0.001). In sum, it seems that there is a decrease in CCT values with age in emmetropic subjects.

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Anatomic Study of the Corneal Thickness of Young Emmetropic Subjects

Abstract: In emmetropic corneas the difference between the minimum paracentral thickness and the maximum paracentral thickness was similar to the difference between the central thickness and the minimum paracentral thickness.

Cited by 25 publications

References 32 publications

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Quantitative Anatomical Differences in Central Corneal Thickness Values Determined With Scanning-Slit Corneal Topography and Noncontact Specular Microscopy

Caucasian Emmetropic Aged Subjects have Reduced Corneal Thickness Values

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