Anatomic, Physiologic and Metabolic Imaging in Neuro-Oncology

Chawla, Sanjeev; Poptani, Harish; Melhem, Elias R.

doi:10.1007/978-0-387-75587-8_1

Cited by 8 publications

(3 citation statements)

References 138 publications

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“…As new volumetric and physiologic imaging techniques [71,72], as well as other end points such as neuropsychologic testing and quality-of-life measures, become validated and more widely available, these parameters will be incorporated into future criteria determining response in highgrade gliomas.…”

Section: Updated Response Criteria In High-grade Gliomasmentioning

confidence: 99%

Response Assessment Challenges in Clinical Trials of Gliomas

et al. 2010

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Accurate, reproducible criteria for determining tumor response and progression after therapy are critical for optimal patient care and effective evaluation of novel therapeutic agents. Currently, the most widely used criteria for determining treatment response in gliomas is based on two-dimensional tumor measurements using neuroimaging studies (Macdonald criteria). In recent years, the limitation of these criteria, which only address the contrast-enhancing component of the tumor, have become increasingly apparent. This review discusses challenges that have emerged in assessing response in patients with gliomas and approaches being introduced to address them.

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Section: Updated Response Criteria In High-grade Gliomasmentioning

confidence: 99%

Response Assessment Challenges in Clinical Trials of Gliomas

et al. 2010

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“…Unfortunately, soft tissue contrast resolution of CT is inferior to MRI [1] even with modern multidetector and dual source scanners, which means that some important intracranial lesions that would have been detected by MRI could be missed on CT.…”

Section: ' 2011 the British Institute Of Radiologymentioning

confidence: 99%

CT stroke window settings: an unfortunate misleading misnomer?

Turner

Holdsworth²

2011

BJR

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ABSTRACT. This commentary will discuss the use of the ''stroke window'' settings in the evaluation of CT head examinations and advocate their more widespread use in patients who present with neurological symptoms in addition to patients with suspected stroke. We present examples of the use of stroke windows, which revealed subtle abnormalities that were not readily apparent on default brain window settings and were subsequently confirmed on MRI or follow-up CT. As a result we suggest that stroke windows should be routine in the review of all CT head examinations.

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“…Although in vivo MRS is often used for detection and characterization of brain tumors (10), the use of MRS in LSDs has been limited (11,12). High resolution NMR spectroscopy of brain extracts and urine samples of cats with AMD has identified resonances from several oligosaccharides, as well as anomeric proton signals from partially degraded mannose moieties using 2D-NMR spectroscopic techniques (13,14).…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats

Magnitsky¹,

Vite²,

Delikatny³

et al. 2010

NMR Biomed.

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A genetic deficiency of lysosomal alpha-mannosidase causes the lysosomal storage disease alphamannosidosis (AMD), in which oligosaccharide accumulation occurs in neurons and glia. The purpose of this study was to evaluate the role of magnetic resonance spectroscopy (MRS) in detecting the oligosaccharide accumulation in AMD. Five cats with AMD and eight age-matched normal cats underwent in vivo MRS studies with a single voxel short echo time (20 ms) STEAM spectroscopy sequence on a 4.7T magnet. Two voxels were studied in each cat, from the cerebellar vermis and the occipital cortex. Metabolites of brain samples from these regions were extracted with perchloric acid and analyzed by high resolution NMR spectroscopy. A significantly elevated unresolved resonance signal between 3.4 and 4. ppm was observed in the cerebellar vermis and occipital cortex of all AMD cats, which was absent in normal cats. This resonance was shown to be from carbohydrate moieties by high resolution NMR of tissue extracts. Resonances from the Glc-NAc group (1.8-2.2 ppm) along with anomeric proton signals (4.6-5.4 ppm) from undigested oligosaccharides were also observed in the extract spectra from AMD cats. This MRS spectral pattern may be a useful biomarker for AMD diagnosis as well as for assessing responses to therapy.

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Anatomic, Physiologic and Metabolic Imaging in Neuro-Oncology

Cited by 8 publications

References 138 publications

Response Assessment Challenges in Clinical Trials of Gliomas

Response Assessment Challenges in Clinical Trials of Gliomas

CT stroke window settings: an unfortunate misleading misnomer?

Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats

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