Anatomic Location and Histopathologic Subtype of Basal Cell Carcinomas in Adults Younger than 40 or 90 and Older

Betti, Roberto; Radaelli, Giovanni; Mussino, Fabio; Menni, S.; Crosti, C.

doi:10.1111/j.1524-4725.2008.34410.x

Cited by 40 publications

(59 citation statements)

References 24 publications

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“…This latter type was associated with lesions on the neck, trunk and limbs and with younger ages in women, which gives weight to earlier observations that this may be a type of lesion that is physiopathologically different from other types of BCC. 24,25 The superficial histological type and lesions located on the trunk were more common at younger ages only in the group of female patients. This, associated with the trend described above of an increase in the proportion of extra-cephalic lesions in this subgroup, may indicate that the risk behavior for this type of lesion, such as greater recreational exposure to the sun, particularly when the lesion is situated on the trunk, represents a more recent type of behavior in women compared to men.…”

Section: Discussionmentioning

confidence: 99%

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

Souza

Thomé

Menegotto

et al. 2011

An. Bras. Dermatol.

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BACKGROUND: Basal cell carcinoma accounts for 75% of skin cancer. Sun exposure and genetics are related to its etiology. It's expected that biological and behavioral differences provide different patterns of involvement between sexes. OBJECTIVES: To evaluate the topography of lesions and their correlations with gender, age and histological type. METHODS: Retrospective study of basal cell carcinoma patients treated between 1999 and 2008 in the Skin Cancer Clinic of Santa Casa de Misericordia of Curitiba. We evaluated sex, age, location, histological type, margins commitment, sun exposure and family skin cancer history. RESULTS: We found 1042 lesions in 545 patients (61% women), being more numerous in men (p<0.01). Their ages ranged between 27 and 95 years (median=65). Men had more sun exposure (p<0.01). The lesions were more frequent extra-cephalic recently (p<0.01). The margin involvement was higher in the head (p<0.01). The superficial type was less frequent on the head (p<0.01) and was associated with younger ages in women (p<0.01). The head housed 74% of lesions and the legs 2%. Women had a predilection for the legs, nose and upper lip and men to trunk, ears and scalp (p <0.05). The surgeries in the medial epicanthus and scalp occurred at younger ages (p=0.01). CONCLUSIONS: We identified significant associations between the topography of lesions, gender, age and histological type, demonstrating the possible pathophysiological diversity and differential risk factors operation. In the period studied we found no trend of increase in the proportion of young or women among patients. Keywords: Age distribution; Carcinoma, basal cell; Pathology; Sex distribution; Topography Resumo: FUNDAMENTOS: O carcinoma basocelular corresponde a 75% dos tumores cutâneos. A exposição solar e a genética estão relacionadas à sua etiologia. Espera-se que diferenças comportamentais e biológicas proporcionem padrões diferenciados de acometimento entre os sexos. OBJETIVOS: Avaliar a topografia das lesões e suas correlações com gênero, idade e tipo histológico. MÉTODOS: Estudo retrospectivo de pacientes tratados por carcinoma basocelular entre 1999 e 2008 no ambulatório de câncer da pele da Santa Casa de Misericórdia de Curitiba. Avaliamos sexo, idade, localização, tipo histológico, situação das margens, histórico de fotoexposição e antecedentes familiares de câncer cutâneo. RESULTADOS: Contabilizamos 1.042 lesões em 545 pacientes (61% mulheres), sendo mais numerosas nos homens (p < 0,01). As idades variaram entre 27 e 95 anos (mediana = 65). Os homens apresentavam mais fotoexposição (p < 0,01). As lesões extracefálicas foram mais frequentes recentemente (p < 0,01). O comprometimento de margens foi maior na cabeça (p < 0,01). O tipo superficial foi menos frequente na cabeça (p < 0,01) e se associou a idades menores nas mulheres (p < 0,01). A cabeça abrigou 74% das lesões, e as pernas, 2%. As mulheres apresentaram predileção para pernas, nariz e lábio superior e os homens para tronco, orelhas e couro cabeludo (p < 0,05). As ciru...

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Section: Discussionmentioning

confidence: 99%

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

Souza

Thomé

Menegotto

et al. 2011

An. Bras. Dermatol.

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“…7,9,15 Owing to their tendency for deeper invasion and an increased likelihood for perineural invasion, 16 the higher-risk types are more difficult to treat because they often involve more extensive surgery, an increased number of stages when treated with Mohs micrographic surgery, 15,17 and not all treatment modalities are suitable for such tumors. 8,18,19 The distribution of BCC by age, subtype, and anatomic distribution was recently studied by Betti et al 20 They found that younger patients are less likely to present with BCCs on the head and neck compared with elderly patients, but there was no difference in the incidence in the more aggressive subtype morpheic (morpheaform or sclerosing) BCC between the age groups. 20 Betti et al 21 revisited the concept of differential presentation of BCC by anatomic location and histologic subtype more recently and concluded that more aggressive subtypes (morpheic and infiltrative) are far more likely to present on the head and neck compared with other locations (odds ratio 4.6, 95% confidence interval 3.42-6.08).…”

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confidence: 97%

Basal cell carcinoma on the ear is more likely to be of an aggressive phenotype in both men and women

Jarell

Mully

2012

Journal of the American Academy of Dermatology

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“…Morpheic BCCs were mostly on the head and neck, and prevalence did not differ between age groups. Nodular BCCs were mostly on the head and neck in older patients [11].…”

Section: Discussionmentioning

confidence: 99%

Addiction to Tanning - A New Cause of Early Onset of Nonmelanoma Skin Cancer

Wollina¹

2009

TODJ

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Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer world wide. UV exposure plays a significant role in the pathogenesis of this tumor that is more common in older people. In the past, BCC in people younger than 30 years of age have been seen in connection with genetic diseases like Gorlin-Goltz syndrome. The histological type was mostly superficial and most common localization was on the trunk. Nowadays, frequent indoor tanning is a risk behavior that might lead to early development of facial and aggressive BCC in people younger than 30 years of age. This is illustrated by a case report of a 29-year old addictive indoor tanner, skin type I, who developed a solid BCC of the nose after more than 10 years of weekly tanning. Current health campaigns and preventive programs seem to be ineffective in this subgroup of patients. New strategies need to be developed.

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Anatomic Location and Histopathologic Subtype of Basal Cell Carcinomas in Adults Younger than 40 or 90 and Older

Abstract: A different distribution of site and subtype occurs in younger and older patients. Subtype is associated with site independent of age and sex. These findings suggest that, at least in some patients, the anatomic location of BCC may favor the development of a particular subtype.

Cited by 40 publications

References 24 publications

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

Topografia do carcinoma basocelular e suas correlações com o gênero, a idade e o padrão histológico: um estudo retrospectivo de 1.042 lesões

Basal cell carcinoma on the ear is more likely to be of an aggressive phenotype in both men and women

Addiction to Tanning - A New Cause of Early Onset of Nonmelanoma Skin Cancer

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