Anatomic correction of transposition of the great arteries associated with ventricular septal defect: midterm results in 50 patients.

Bical, O; Hazan, E; Lecompte, Y; Fermont, L; Karam, Joseph; Jarreau, Marie‐Madeleine; Viet, Tien Tran; Sidi, Daniel; Leca, F; Neveux, Jean-Yves

doi:10.1161/01.cir.70.5.891

Cited by 46 publications

(9 citation statements)

References 14 publications

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“…The heart weight to body weight ratios of the hearts included in our study are shown in Table 1. The heart to body weight ratios shown for the nonbanded control hearts (7.6 g heart wt/kg body wt) are in good agreement with previously published data (7.4 g heart wt/kg body wt) (13). It should be noted that to obtain meaningful statistics it was necessary to group the banded hearts.…”

Section: Physiologic Studies Of Banded and Nonbanded Heartssupporting

confidence: 88%

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Troponin T Expression in Normal and Pressure-Loaded Fetal Sheep Heart

McAuliffe

Robbins

1991

Pediatr Res

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ABSTRACT. The effects of cardiac hypertrophy in adult patients with Tetralogy of Fallot, although the pattern of Mhc animals on the expression of a number of genes are well isotype expression was not changed. More is known about the established. There is, however, a paucity of information response of the adult myocardium to pressure overload. It is now about the effect of pressure overload on the expression of well documented, in various animal models of cardiac hypertrogenes coding for the contractile proteins in the prenatal phy, that perturbations occur. Often, in the adult models, the developing heart. The prenatal cardiac muscle can increase reexpression of fetal or perinatal isoforms is observed (5-7). cell number in response to stress, whereas the adult heart Additionally, changes in the levels of expression of enzymes increases cell mass. Thus, the response of the fetal heart associated with Ca2+ handling, such as the sarcoplasmic reticuto pressure overload cannot be assumed to be identical to lum AT^^^^, have been noted (8).that of adult myocardium. W e studied the effect of banding These alterations in gene expression appear to be an intrinsic the great vessels of fetal sheep hearts on the expression of property of the myocardium. The change in the pattern of troponin (TNT). In other vertebrates, TNT mRNA is expression of a given protein varies from animal to animal. For generated by alternative splicing of a primary transcript. example, in the smaller rodents, in response to hypertrophy Thus, both the levels and patterns of TNT isOforms caused by pressure overload induced by banding, a shift from crated by alternative splicing in the heart could be influ-the V, to Vi Mhc isOtype in the loaded ventricle occurs (9); such enced by pressure overload.

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Section: Physiologic Studies Of Banded and Nonbanded Heartssupporting

confidence: 88%

“…Prior studies have found gradients varying from 15-45 mm Hg (13)(14). In the study of Shapiro et al (15), the RV pressure was found to be 9-93% greater than LV pressure in five of six animals studied, but 18% less than LV pressure in one animal.…”

Section: Discussionmentioning

confidence: 99%

Troponin T Expression in Normal and Pressure-Loaded Fetal Sheep Heart

McAuliffe

Robbins

1991

Pediatr Res

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“…21,70 –76 Prevalence of aortic regurgitation in patients who have reached 20 years of age is not known, but may be appreciable. 77 More importantly, the frequency of the regurgitation after ASO seems to increase with time 48,52,55,58,59,78,79 and isolated cases have had significant regurgitation requiring valve replacement. 27,80 –82…”

Section: Neoaortic Valve Regurgitation and Stenosismentioning

confidence: 99%

Outcomes after Arterial Switch Operation for Simple Transposition

Raja¹,

Shauq

Kaarne

2005

Asian Cardiovasc Thorac Ann

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Without intervention, babies born with transposed great arteries (TGA) are doomed to a rapid death. Jatene and coworkers deserve the credit for performing the first successful arterial switch operation (ASO) in a patient with TGA and ventricular septal defect (VSD) in 1975. Since then ASO has become the procedure of choice in most medical centers. This review article summarizes the historical aspects of arterial switch operation and assesses this procedure's outcomes.

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“…The technique of repair, and early results, have been described previously. 15 Patients with small ventricular septal defects not requiring surgery 8 were included in the group with intact ventricular septum. Common additional lesions are detailed in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Early reports described supravalvar pulmonary stenosis in patients where a conduit was used in anastomosis of the pulmonary trunk during the arterial switch. 8 ' 23 Various techniques were devised to avoid this. The Lecompte maneuver has been widely used to obviate the need for such conduits.…”

Section: Right Ventricular and Left Ventricular Outflow Gradientsmentioning

confidence: 99%

Hemodynamic and angiographic findings following arterial switch repair for complete transposition

et al. 1996

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The arterial switch operation is the treatment of choice for complete transposition, and for the Taussig-Bing anomaly, with good early and mid-term results. This retrospective study examined the findings obtained at routine follow-up cardiac catheterization after primary arterial switch repair. We catheterized 111 patients after a mean of 16.9 months after surgery. These included 67 patients with an intact ventricular septum, 33 with a ventricular septal defect, and 11 with the Taussig-Bing anomaly. Right ventricular pressures were mildly elevated (mean 33.9±10.2 mm Hg) in the overall group with a mean pressure ratio between right and left ventricles of 0.34±0.1. Of the patients 74% had gradients across the right ventricular outflow tract of under 20 mm Hg, while three (2.7%) had gradients over 30 mm Hg. A significant gradient across the left ventricular outflow tract occurred in one patient (0.9%), while significant neo-aortic stenosis was not seen. The neo-aortic root remained dilated, with mild aortic valvar incompetence being seen in 12%, with none having higher grades of regurgitation. Left ventricular ejection fraction was normal in all patients, while left ventricular end-diastolic pressure was elevated in 38%. Coronary arterial stenosis was not seen, but one patient (0.9%) had left ventricular apical dyskinesia. Overall, therefore, we conclude that cardiac hemodynamics and ventricular systolic function after primary arterial switch are good. Minor gradients to the pulmonary arteries, and mild neo-aortic valvar incompetence were commonly noted. Left ventricular end-diastolic pressure was elevated in over a third of the patients. These subclinical and subtle abnormalities warrant ongoing follow-up to determine their long-term significance.

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Anatomic correction of transposition of the great arteries associated with ventricular septal defect: midterm results in 50 patients.

Cited by 46 publications

References 14 publications

Troponin T Expression in Normal and Pressure-Loaded Fetal Sheep Heart

Troponin T Expression in Normal and Pressure-Loaded Fetal Sheep Heart

Outcomes after Arterial Switch Operation for Simple Transposition

Hemodynamic and angiographic findings following arterial switch repair for complete transposition

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