Anatomic and electro-physiologic connectivity of the language system: A combined DTI-CCEP study

Conner, Christopher R.; Ellmore, Timothy M.; Disano, Michael A.; Pieters, Thomas A.; Potter, Andrew W.; Tandon, Nitin

doi:10.1016/j.compbiomed.2011.07.008

Cited by 84 publications

(79 citation statements)

References 68 publications

(96 reference statements)

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“…This procedure is repeated 10-50 times for signal averaging of the evoked response. CCEPs typically consist of an early (10-30 ms) negative surface deflection termed the N1 and a later (80-250 ms) slow wave termed the N2 (figure 2a) [50,52,[61][62][63]. Considerable waveform heterogeneity of the N1 and N2 components of the CCEP exists across spatially diverse recording sites following stimulation (figure 2b).…”

Section: (B) Overview Of Cortico-cortical Evoked Potentialsmentioning

confidence: 99%

“…provide a neuronal basis of neuroimaging signals that are used widely to study brain connectivity and function. For example, the N1 of the CCEP partially reflects both structural [61] and functional [52] connections between cortical regions, whereas the N2 partially reflects functional connections [52]. The N1 potential occurs between 10 and 30 ms and is thought to reflect excitation of local cortex ( [62]; see Information in Box 1).…”

Section: Relationship Between Anatomical Functionalmentioning

confidence: 99%

“…Additionally, seizure-generating regions in each patient can be compared to similar anatomical but non-seizure-generating regions in a large population to serve as a control. Finally, CCEP databases based on the grids and strips approach [50,52,60,61,63,66] can supplement those based on the SEEG approach [67,118], and both can be compared to other effective connectivity measures including microstimulation and TMS.…”

Section: Limitations Of Cortico-cortical Evoked Potential Mappingmentioning

confidence: 99%

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Mapping human brain networks with cortico-cortical evoked potentials

Keller

Honey

Mégevand

et al. 2014

Phil. Trans. R. Soc. B

182

212

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The cerebral cortex forms a sheet of neurons organized into a network of interconnected modules that is highly expanded in humans and presumably enables our most refined sensory and cognitive abilities. The links of this network form a fundamental aspect of its organization, and a great deal of research is focusing on understanding how information flows within and between different regions. However, an often-overlooked element of this connectivity regards a causal, hierarchical structure of regions, whereby certain nodes of the cortical network may exert greater influence over the others. While this is difficult to ascertain non-invasively, patients undergoing invasive electrode monitoring for epilepsy provide a unique window into this aspect of cortical organization. In this review, we highlight the potential for cortico-cortical evoked potential (CCEP) mapping to directly measure neuronal propagation across large-scale brain networks with spatio-temporal resolution that is superior to traditional neuroimaging methods. We first introduce effective connectivity and discuss the mechanisms underlying CCEP generation. Next, we highlight how CCEP mapping has begun to provide insight into the neural basis of non-invasive imaging signals. Finally, we present a novel approach to perturbing and measuring brain network function during cognitive processing. The direct measurement of CCEPs in response to electrical stimulation represents a potentially powerful clinical and basic science tool for probing the large-scale networks of the human cerebral cortex.

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Section: (B) Overview Of Cortico-cortical Evoked Potentialsmentioning

confidence: 99%

Section: Relationship Between Anatomical Functionalmentioning

confidence: 99%

Section: Limitations Of Cortico-cortical Evoked Potential Mappingmentioning

confidence: 99%

See 1 more Smart Citation

Mapping human brain networks with cortico-cortical evoked potentials

Keller

Honey

Mégevand

et al. 2014

Phil. Trans. R. Soc. B

182

212

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“…Current induced by stimulation is likely to spread through direct connections, as illustrated by numerous cortico-cortical evoked potential studies (Conner et al, 2011;Matsumoto et al, 2004). This does not cause a major problem if the network of interest is based on direct connections, in which case the current spread is likely to be intended for network stimulation.…”

Section: The Road Ahead: Additional Considerations Regarding Direct Vmentioning

confidence: 99%

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Kim¹,

Ekstrom

Tandon³

2016

Neurobiology of Learning and Memory

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A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. that disrupting frontal or parietal regions also impairs memory performance, suggesting that these regions also play necessary roles in declarative memory. On the other hand, a handful of both invasive and non-invasive studies have also suggested modest improvements in memory performance following stimulation. These studies typically target brain regions connected to the hippocampus or other memory "hubs," which may affect endogenous activity in connected areas like the hippocampus, suggesting that to augment declarative memory, altering the broader endogenous memory network activity is critical. Together, studies reporting memory improvements / impairments are consistent with the idea that a network of distinct brain "hubs" may be crucial for successful memory encoding and retrieval rather than a single primary hub such as the hippocampus. Thus, it is important to consider neurostimulation from the network perspective, rather than from a purely localizationalist viewpoint. We conclude by proposing a novel approach to neurostimulation for declarative memory modulation that aims to facilitate interactions between multiple brain "nodes" underlying memory rather than considering individual brain regions in isolation.

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“…Actual stimulus intensities in the present study varied from 3 to 8 mA, which is lower than the 10-15 mA used in previous studies of extraoperative CCEP recordings in patients with epilepsy. 4,7,8,21 The reference electrode was placed in the area of the contralateral mastoid process. The bandpass filter for data acquisition was set at 5-1500 Hz with a sampling rate of 5000 Hz for each channel.…”

Section: Intraoperative Ccep Monitoringmentioning

confidence: 99%

Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection: initial experience with 13 cases

Saito¹,

Tamura

Muragakı

et al. 2014

JNS

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Object The objective in the present study was to evaluate the usefulness of cortico-cortical evoked potentials (CCEP) monitoring for the intraoperative assessment of speech function during resection of brain tumors. Methods Intraoperative monitoring of CCEP was applied in 13 patients (mean age 34 ± 14 years) during the removal of neoplasms located within or close to language-related structures in the dominant cerebral hemisphere. For this purpose strip electrodes were positioned above the frontal language area (FLA) and temporal language area (TLA), which were identified with direct cortical stimulation and/or preliminary mapping with the use of implanted chronic subdural grid electrodes. The CCEP response was defined as the highest observed negative peak in either direction of stimulation. In 12 cases the tumor was resected during awake craniotomy. Results An intraoperative CCEP response was not obtained in one case because of technical problems. In the other patients it was identified from the FLA during stimulation of the TLA (7 cases) and from the TLA during stimulation of the FLA (5 cases), with a mean peak latency of 83 ± 15 msec. During tumor resection the CCEP response was unchanged in 5 cases, decreased in 4, and disappeared in 3. Postoperatively, all 7 patients with a decreased or absent CCEP response after lesion removal experienced deterioration in speech function. In contrast, in 5 cases with an unchanged intraoperative CCEP response, speaking abilities after surgery were preserved at the preoperative level, except in one patient who experienced not dysphasia, but dysarthria due to pyramidal tract injury. This difference was statistically significant (p < 0.01). The time required to recover speech function was also significantly associated with the type of intraoperative change in CCEP recordings (p < 0.01) and was, on average, 1.8 ± 1.0, 5.5 ± 1.0, and 11.0 ± 3.6 months, respectively, if the response was unchanged, was decreased, or had disappeared. Conclusions Monitoring CCEP is feasible during the resection of brain tumors affecting language-related cerebral structures. In the intraoperative evaluation of speech function, it can be a helpful adjunct or can be used in its direct assessment with cortical and subcortical mapping during awake craniotomy. It can also be used to predict the prognosis of language disorders after surgery and decide on the optimal resection of a neoplasm.

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Anatomic and electro-physiologic connectivity of the language system: A combined DTI-CCEP study

Cited by 84 publications

References 68 publications

Mapping human brain networks with cortico-cortical evoked potentials

Mapping human brain networks with cortico-cortical evoked potentials

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection: initial experience with 13 cases

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