Anatomía patológica de los tumores del estroma gastrointestinal primarios no metastásicos en España. Resultados del estudio GRISK

Medina, Luis Ortega; Raventós, Vicente Artigas; Argüelles, Álvaro Díaz de Liaño; Hernández, Juan Ángel Fernández; Pousa, Antonio López; Poza, José Luis Lucena de la; Delgado, C.

doi:10.1016/j.patol.2009.11.002

Cited by 1 publication

(2 citation statements)

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“…Its annual incidence rates range from 6.8 and 14.5 cases per million in the U.S. States and in Sweden, respectively [2]. GISTs include benign and malignant neoplasia that immunohistochemically stain positively for KIT (CD117) and that phenotypically differentiate into cells of Cajal.…”

Section: Introductionmentioning

confidence: 99%

“…Subsequently, in 2003, a new mutation in PDGFRA and the sensitivity of GISTs to tyrosine kinase inhibitors such as imatinib were demonstrated. These findings represent an important advance in the clinical management and our understanding of the biology of this tumour [2]. Although the mutations in KIT and PDGFRA represent the basis of GIST oncogenesis, 5-10% of the GIST cases are negative for mutations in KIT [3].…”

Section: Introductionmentioning

confidence: 99%

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Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma

et al. 2012

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BackgroundGastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies in adults (<2%). GISTs can be located at any level of the gastrointestinal tract; the stomach is the most common location (60-70%), in contrast to the rectum, which is most rare (4%). When a GIST invades into the adjacent prostate tissue, it can simulate prostate cancer. In this study, we report on a case comprising the unexpected collision between a rectal GIST tumour and a prostatic adenocarcinoma.FindingsWe describe the complexity of the clinical, endoscopic and radiological diagnosis, of the differential diagnosis based on tumour biopsy, and of the role of neoadjuvant therapy using imatinib prior to surgical treatment.ConclusionsAlthough isolated cases of coexisting GISTs and prostatic adenocarcinomas have previously been described, this is the first reported case in the medical literature of a collision tumour involving a rectal GIST and prostatic adenocarcinoma components.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1238437468776331.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%