Anastomotic leaks in stage IV colorectal cancer

Ng, Suat Chin; Stupart, Douglas; Bartolo, D. C. C.; Watters, David

doi:10.1111/ans.14494

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…We did not find any increase in AL among patients with stage IV rectal cancer treated with RT and operated with AR, even though some retrospective data in the literature suggest such an increase [29]. However, there was an increased risk for AL (OR, 8.72) in patients with stage IV rectal cancer who had been previously treated with RT for prostate cancer, even though this is probably a highly selective group of patients.…”

Section: Discussioncontrasting

confidence: 76%

Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer

Sverrisson

Folkvaljon

Chabok

et al. 2019

European Journal of Surgical Oncology

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Introduction: There are little data on the post-operative outcome of anterior resection (AR) for rectal cancer in men who had received radiotherapy for prostate cancer previously. The aim of this study was to assess the rate of anastomotic leakage (AL) after AR in these patients. Methods: All men who underwent bowel resection because of rectal cancer between 2000 and 2016 and had been diagnosed previously with prostate cancer were identified by linking the Swedish Colorectal Cancer Registry with the National Prostate Cancer Register. The medical records of men who underwent AR and had previously received radiotherapy for prostate cancer were reviewed. Results: In total, 13299 men had undergone a bowel resection for rectal cancer, 188 of whom had previously received radiotherapy for prostate cancer. Among those who had received radiation therapy, 59 men (31%) had an AR: 50 men (85%) received a diverting ileostomy, 42 men (71%) had an American Society of Anesthesiologists score of 1e2 and 36 men (61%) had tumour stage 1e2. AL was found in 12/59 men (20%), one of whom had a re-laparotomy. There was no 90-day mortality. Conclusions: In the combined national population-based registries, a minority of patients with rectal cancer had an AR after previous radiotherapy for prostate cancer. These patients were healthy with early cancer stages and, in this selected group of patients, the AL rate was much lower than that reported previously.

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Section: Discussioncontrasting

confidence: 76%

Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer

Sverrisson

Folkvaljon

Chabok

et al. 2019

European Journal of Surgical Oncology

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“…Several studies examined the impact of the disease stage at the time of surgery on the occurrence of AL, with somewhat inconsistent results 11,[15][16][17][18] . While Bakker et al 11 showed no influence of the disease stage on the occurrence of AL, Ng et al 16 report a threefold, and Kaser et al 17 even fourfold increase in the likelihood of AL in patients with metastatic disease at the time of surgery. In our study, histologic grade of tumor 19,20 .…”

Section: Discussionmentioning

confidence: 99%

Difference in Predictors of Anastomotic Leakage Depending on the Level of Anastomosis after Colorectal Cancer Surgery

Jašarović

Stojanović

Mitrović

et al. 2021

ACC

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Anastomotic leak (AL) after colorectal cancer surgery is one of the most serious postoperative complications which has major impact on outcomes. The aim of this study was to investigate preoperative and intraoperative risk factors for AL, as well as to examine whether there are differences in risk factors for AL depending on the primary tumor location. We retrospectively reviewed records of patients having undergone colorectal surgical procedures for malignancies between January 2013 and December 2017 in a single institution. Only procedures with primary anastomosis were included. Of the 153 patients, AL occurred in 10.6% of patients with primary tumor in the sigmoid colon and rectum, and in 8.2% of patients with primary tumor in the proximal sections of the colon. On univariate analysis, delayed oral intake and more advanced histologic stages of the tumor were significantly correlated with AL in patients with tumors in the sigmoid colon and rectum, and multiorgan resection and distant metastases in patients with tumors in the proximal sections of the colon. In conclusion, risk factors for the occurrence of AL vary depending on the primary tumor location and further investigation is needed to provide better insight into these differences.

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“…Accordingly, cancer stage was not included in the analysis, though several studies have demonstrated the negative impact of stage IV disease on ALs and overall morbidity. 38 Also, the NSQIP mortality data did not include the cause of death. Mortality in AL patients was assumed to be secondary to overwhelming sepsis or an event secondary to an overall proinflammatory state, causing potential misclassification bias in our failure to rescue analysis.…”

Section: Discussionmentioning

confidence: 99%

Predicting Anastomotic Leak After Elective Colectomy: Utility of a Modified Frailty Index

Dressler

Shah

Lueckel

et al. 2022

Diseases of the Colon &Amp; Rectum

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BACKGROUND: Anastomotic leak is the most dreaded complication following colonic resection. While patient frailty is increasingly being recognized as a risk factor for surgical morbidity and mortality, the current colorectal body of literature has not assessed the relationship between frailty and anastomotic leak.OBJECTIVE: Evaluate the relationship between patient frailty and anastomotic leak as well as patient frailty and failure to rescue in patients who experienced an anastomotic leak.

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Anastomotic leaks in stage IV colorectal cancer

Cited by 10 publications

References 11 publications

Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer

Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer

Difference in Predictors of Anastomotic Leakage Depending on the Level of Anastomosis after Colorectal Cancer Surgery

Predicting Anastomotic Leak After Elective Colectomy: Utility of a Modified Frailty Index

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