Anastomotic leakage and presacral abscess formation after locally advanced rectal cancer surgery: Incidence, risk factors and treatment

Vermeer, T.A.; Orsini, R.G.; Daams, Freek; Nieuwenhuijzen, Grard A. P.; Rutten, H.J.T.

doi:10.1016/j.ejso.2014.03.019

Cited by 55 publications

(32 citation statements)

References 38 publications

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“…The etiology of rectal cancer is still not very clear, and the incidence is closely linked to the social environment, eating habits, genetic factors, and others. It is generally accepted that superabundant animal fat and protein intake and inadequate dietary fiber intake are high risk factors for rectal cancer (Vermeer et al, 2014;Zhang et al, 2014a). Because of the low location of the disease, it is easy to be diagnosed by digital rectal examination and sigmoidoscopy (Maas et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Metabolomics for Identification of Metabolic Pathways and Deciphering the Effect Mechanism of Dioscin on Rectal Cancer From Cell Metabolic Profiles Coupled With Chemometrics Analysis

Wang

2020

Front. Pharmacol.

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High-throughput liquid chromatography-mass spectrometry (LC-MS)-based metabolomics can provide the holistic analysis of the low molecular weight endogenous metabolites in cells and reflect the changes of cellular regulation and metabolic pathways. Our study designed to reveal the potentially pharmacological effects of dioscin on SW480 rectal cancer cells using nontargeted metabolomics method to probe into small molecular metabolites and pathway changes. After the cell assay of proliferation, apoptosis, migration, and invasion, the dioscin-treated cell samples were prepared for nontargeted metabolomics analysis based on LC-MS tool to describe the metabolic profiles. Dioscin has prevented cell proliferation and accelerated cell apoptosis, and it also inhibited the SW480 rectal cancer cells' migration and invasion. A total of 22 metabolites were selected as promising biomarkers of pharmacological reaction of dioscin to rectal cancer, and eight highly correlated pathways including D-glutamine and D-glutamate metabolism, pyruvate metabolism, arachidonic acid metabolism, phenylalanine metabolism, tryptophan metabolism, glycolysis or gluconeogenesis, citrate cycle (TCA cycle), and butanoate metabolism were identified. It showed that strategies based on cell metabolomics are helpful tools to discover the small molecular metabolites to elucidate the action mechanism of drug.

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Section: Introductionmentioning

confidence: 99%

High-Throughput Metabolomics for Identification of Metabolic Pathways and Deciphering the Effect Mechanism of Dioscin on Rectal Cancer From Cell Metabolic Profiles Coupled With Chemometrics Analysis

Wang

2020

Front. Pharmacol.

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“…A potential application of this membrane can be represented by the need of promoting a faster closure of intestinal wounds following an anastomotic procedure. In fact, anastomotic leakage after the surgical treatment of intestinal cancers remains a major clinical concern and effective solutions are yet to be found [21,22]. In this perspective, such a polysaccharide-based membrane could be wrapped around the sutured part of the intestine (anastomosis) in order to enable the in situ release of the bioactive component (HA), thus promoting a faster wound closure.…”

Section: Introductionmentioning

confidence: 99%

Enhanced bioadhesivity of dopamine-functionalized polysaccharidic membranes for general surgery applications

et al. 2016

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“…Despite advances in surgical technique, anastomotic complications continue to be associated with a significant rate of morbidity and mortality; including potential permanent stoma formation, increased length of hospital stay [2], increased local recurrence [3] and significant financial implications for an ever strained health service. Anastomotic leaks occur in 5–15% of patients following a colorectal anastomosis [4–6] and are more frequently observed in those of a male sex, a BMI > 35 kg/m 2 , those who have had pre-operative chemo-radiation, or patients with tumours > 5 cm in size or within 7 cm of the anal verge [7]. Intraoperative assessment of anastomotic integrity is now common practice, whether by an air leak test, endoscopy, intraoperative dye test or laser fluorescence angiography.…”

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confidence: 99%

Early anastomotic complications in colorectal surgery: a systematic review of techniques for endoscopic salvage

et al. 2019

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BackgroundAnastomotic complications following colorectal surgery are associated with significant morbidity and mortality. For patients in whom systemic sepsis is absent or well controlled, minimal access techniques, such as endoscopic therapies, are being increasingly employed to reduce the morbidity of surgical re-intervention. In this review, we aim to assess the utility of endoscopic management in the acute setting of colorectal anastomotic complications, focusing on anastomotic leak.MethodA literature search was performed for published full text articles using the PubMed, Cochrane and Scopus databases using the search criteria string “colorectal anastomotic (“leak” OR “bleed”), “endoscopy”, endoscopic management”. Additional papers were detected by scanning the references of relevant papers. Data were extracted from each study by two authors onto a dedicated pro-forma. Given the nature of the data extracted, no meta-analysis was performed.ResultsA total of 89 papers were identified, 16 of which were included in this review; an additional 14 papers were obtained from reference searches. In patients who are not physiologically compromised, there are promising data regarding the salvage rate of stents, over-the-scope endoscopic clips, vacuum therapy and fibrin glue in the early management of colorectal anastomotic leak. There is no consensus regarding the optimal approach, and data to assist the physician in patient selection are lacking. Whilst data on salvage (i.e. healing and avoidance of surgery) are well understood, no data on functional outcomes are reported.ConclusionEndoscopic therapy in the management of stable patients with colorectal anastomotic leaks appears safe and in selected patients is associated with high rates of technical success. Challenges remain in selecting the most appropriate strategy, patient selection, and understanding the functional and long-term sequelae of this approach. Further evidence from large prospective cohort studies are needed to further evaluate the role of these novel strategies.

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Anastomotic leakage and presacral abscess formation after locally advanced rectal cancer surgery: Incidence, risk factors and treatment

Cited by 55 publications

References 38 publications

High-Throughput Metabolomics for Identification of Metabolic Pathways and Deciphering the Effect Mechanism of Dioscin on Rectal Cancer From Cell Metabolic Profiles Coupled With Chemometrics Analysis

High-Throughput Metabolomics for Identification of Metabolic Pathways and Deciphering the Effect Mechanism of Dioscin on Rectal Cancer From Cell Metabolic Profiles Coupled With Chemometrics Analysis

Enhanced bioadhesivity of dopamine-functionalized polysaccharidic membranes for general surgery applications

Early anastomotic complications in colorectal surgery: a systematic review of techniques for endoscopic salvage

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