Anästhetikainduzierte Neurotoxizität

Becke, Karin; Schreiber, Markus; Philippi-Höhne, C.; Strauß, J.; Engelhard, Kristin; Sinner, Barbara

doi:10.1007/s00101-013-2143-4

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…[ 24 ] Consequently, its administration in the epidural space has been seriously questioned recently,[ 25 ] and the use of neuraxial ketamine for pediatric postoperative analgesia is decreasing in some countries. [ 26 ] Although no major neurological complications after a single dose of 0.25–0.5 mg/kg ketamine were observed,[ 27 ] preclinical safety studies and larger long-term epidemiological trials investigating possible neurological complications after CK administration are warranted, and topical administration of ketamine could be a safe alternative.…”

Section: Discussionmentioning

confidence: 99%

Topical versus caudal ketamine/bupivacaine combination for postoperative analgesia in children undergoing inguinal herniotomy

Abdel‐Ghaffar

Moeen

2017

Saudi J Anaesth

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Background:Multiple studies claim that caudal administration of ketamine causes effective postoperative analgesia. The aim of this study was to assess the clinical effectiveness of ketamine after caudal or topical administration in pediatric patients undergoing inguinal herniotomy.Patients and Methods:This randomized, comparative, double-blind study included eighty children (aged 6 months to 6 years) received either 1 ml/kg of 0.25% bupivacaine/ketamine 0.5 mg/kg for caudal analgesia (caudal group) or 0.3 ml/kg of 0.25% bupivacaine/ketamine 0.5 mg/kg sprayed by the surgeon around the spermatic cord and upon the ilioinguinal nerve before wound closure for topical analgesia (topical group). The duration of postoperative analgesia, pain scores, rescue analgesic consumption, sedation score, hemodynamic monitoring, and side-effects were evaluated 48 h postoperative.Results:Kaplan–Meier survival analysis of analgesia free time demonstrated a significant advantage of topical ketamine (TK) group over caudal ketamine (CK) group. The duration of postoperative analgesia was longer in TK group than in CK group (28.74 ± 2.88 vs. 21.43 ± 5.01 h, P = 0.000). Fewer children asked for oral analgesics in the topical group (24 of 36, 66.7%) than in the caudal one (28 of 32, 87.5%; P < 0.01). Postoperative pain scores at the 6th till 48th h were lower in topical group with comparable analgesic consumption between two groups. In the caudal group, four subjects suffered from retention of urine: Two presented with a residual motor block and two had photophobia.Conclusion:Wound instillation of bupivacaine/ketamine is a simple, noninvasive, and effective technique that could be a safe alternative to CK for postoperative analgesia in children undergoing inguinal hernia repair.

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Section: Discussionmentioning

confidence: 99%

Topical versus caudal ketamine/bupivacaine combination for postoperative analgesia in children undergoing inguinal herniotomy

Abdel‐Ghaffar

Moeen

2017

Saudi J Anaesth

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“…Balancierte Anästhesietechniken mit kombiniertem Einsatz von Regional- bzw. Lokalanästhesie, Opioiden, Nichtopioidanalgetika und Anästhetika sind sicher und unbedenklich 9 .…”

Section: Indikationen Der Mic Bei Neugeborenen Und Säuglingenunclassified

Minimalinvasive Chirurgie beim Neugeborenen

Wessel¹,

Kaiser²

2022

Neonatologie Scan

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“…“There are nearly no hints that competently performed and clinically well supervised anesthesia with modern shortly effective anesthetics was associated with negative consequences such as cognitive retardation or learning disability” [ 670 ], [ 671 ].…”

Section: Indications Of Surgery Beyond Chronic Rhinosinusitismentioning

confidence: 99%