Anästhesie bei seltenen Erkrankungen

Bíró, Péter; Vagts, Dierk A.; Emmig, Uta; Kaltofen, Heike

doi:10.1007/978-3-662-44368-2

Cited by 2 publications

(2 citation statements)

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“…The anesthetic risk is present at each procedure but particular syndromes may provide an additional risk. 18 However, very little is known about the anesthetic risk of MWS. The survey through social media has advantages and disadvantages, as well summarized in a recent article by William Davies: 19 fast turnaround, low costs, a large number of patients recruited (often seen individually in different hospitals) but the evaluation of the point of view of the individuals or the caregivers, the compilation of retrospective questionnaire was on a voluntary basis and this may introduce an additional bias.…”

Section: Discussionmentioning

confidence: 99%

Anesthesia in Mowat-Wilson Syndrome: Information on 11 Italian Patients

Spunton¹,

Garavelli

Mainardi

et al. 2018

Pediatric Reports

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Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the ZEB2 gene and characterized by typical clinical features. The congenital malformations typical of this syndrome call for early diagnostic and surgical procedures requiring general anesthesia, but few information about the anesthesiology management of such patients is available. We enrolled 11 families of patients with Mowat-Wilson syndrome who had undergone surgical or diagnostic procedures requiring general anesthesia, and sent them a retrospective questionnaire including 16 open questions about the procedures. They were further contacted by phone for a semistructured interview. A total of 37 procedures requiring general anesthesia was reported in 11 patients. Only two patients reported anesthesia-related complications during the procedure. No true additional anesthesiarelated risk was present for the patients with MW syndrome, besides difficult intubation, weaning and lower respiratory tract infection. Perception of risk, however, is derived by non-medical observation on the part of the parents.

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Section: Discussionmentioning

confidence: 99%

Anesthesia in Mowat-Wilson Syndrome: Information on 11 Italian Patients

Spunton¹,

Garavelli

Mainardi

et al. 2018

Pediatric Reports

Self Cite

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“…Рассматриваемая проблема перспективна для дальнейшей разработки, учитывая высокую частоту этого состояния, низкую информированность анестезиологов о его природе, появление новых препаратов для общей анестезии, многокомпонентность самой анестезии, что повышает риск развития ЦАС [14]. Также следует отметить, что при использовании галантамина как универсального препарата для профилактики ЦАС и декураризации уменьшается общее…”

Section: результаты и их обсуждениеunclassified

Central anticholinergic syndrome following general anaesthesia: prevention and treatment with galantamine

Данилов

Лебединский

Kurapeev

2018

HERALD of North-Western State Medical University named after I.

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Prolonged emergence, excitation and shivering after general anaesthesia are well-known, though only in German-speaking countries they are considered to be forms of single central anticholinergic syndrome (CAS), while in others this term is not associated with general anaesthesia. In Russia the problem is augmented with lack of physostigmine — the first choice for CAS in Germany. We present our analysis of implementing galantamine instead of physostigmine for CAS prevention and management while administering this drug for decurarization. 130 patients undergoing general anaesthesia were divided into three groups depending on decurarization — group I (n = 54) without decurarization, in group II (n = 29) we used galantamine, in group III (n = 47) — neostigmine. In all the groups we assessed CAS incidence and its galantamine treatment effectiveness. Diagnostic criteria for CAS comatose form was unconsciousness 5 min later reaching inhalational agent zero end-expiratory concentration. Using the criteria we found CAS incidence in group I was 26,9%, in group II there were no cases of the syndrome, in group III the incidence was 14,9%. Thus, galantamine 0,3–0,4 mg · kg–1 (max 0,78 mg · kg–1) IV not only prevents CAS but is also effective in its treatment.

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Anästhesie bei seltenen Erkrankungen

Cited by 2 publications

References 0 publications

Anesthesia in Mowat-Wilson Syndrome: Information on 11 Italian Patients

Anesthesia in Mowat-Wilson Syndrome: Information on 11 Italian Patients

Central anticholinergic syndrome following general anaesthesia: prevention and treatment with galantamine

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