Anaplastic Thyroid Carcinoma in a Young Woman: A Rare Case of Survival

Pichardo-Lowden, Ariana; Durvesh, Saima; Douglas, S.F.; Todd, William U.; Bruno, Michael A.; Goldenberg, David

doi:10.1089/thy.2009.0025

Cited by 20 publications

(9 citation statements)

References 32 publications

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“…Interestingly, this case harbored neither TERT promoter mutation nor BRAF V600E mutation as examined in the present study. There have been many case reports on similar long-term survivors of ATC (27)(28)(29)(30)(31)(32)(33)(34). It would be interesting to know if such cases of ATC, like our case, also do not harbor TERT promoter mutations.…”

Section: Notesmentioning

confidence: 75%

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

Shi

Liu

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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Section: Notesmentioning

confidence: 75%

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

Shi

Liu

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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“…ATC is usually a disease of the elderly however, the diagnosis has also been made in those under Months Fig. 1 Overall disease specific survival 50 [7,8]. The male to female ratio was 1.1:1.…”

Section: Discussionmentioning

confidence: 99%

Dyspnea as a prognostic factor in anaplastic thyroid carcinoma

Tashima

Mitzner

Durvesh

et al. 2011

Eur Arch Otorhinolaryngol

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Anaplastic thyroid cancer (ATC) is a rare but aggressive form of thyroid cancer. In this study, we review a single institution's experience with ATC over past 34 years. Through retrospective review, we attempted to identify the prognostic factors affecting the survival at our institution. We reviewed the records of 33 patients diagnosed with ATC by pathology over the last three decades. At our institution, median age at diagnosis was 68 years, the male to female ratio was 1.1:1, mean survival was 10 months and median survival was 4.7 months. Thirty-nine percentage of patients were treated with chemotherapy and 52% received radiation treatment. Thirty-six percentage received both chemotherapy and radiation and 58% of patients were treated with surgical intervention. Four of the patients received surgical intervention with curative intent. Tracheotomy was performed in 40% of patients. Eight patients survived more than 10 months. Univariate analysis showed that age greater than 60 and dyspnea at presentation were associated with decreased survival and that surgical intervention was associated with increased survival. Multivariate analysis identified only dyspnea at the time of presentation to be a significant independent prognostic factor affecting the mortality. While long-term survival is possible in some patients, ATC has a poor prognosis despite the attempts at aggressive treatment. In this study, we report that dyspnea was the only independent factor found to negatively affect the survival. This finding is unique in our study and supports the role of using signs at the time of presentation as potential prognostic factors for those patients with this aggressive disease.

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“…The oldest person with anaplastic thyroid cancer was 104 years old [6]. Anaplastic thyroid cancer is rare under 40 years of age [9]. In childhood, its appearance is quite rare and has been described only in few cases in the world.…”

Section: Discussionmentioning

confidence: 99%

Age as a Prognostic Factor in Anaplastic Thyroid Cancer

Živaljević

Tausanovic

Paunović

et al. 2014

International Journal of Endocrinology

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Background. Anaplastic thyroid cancer (ATC) is one of the tumors with the shortest survival in human medicine. Aim. The aim was to determine the importance of age in survival of patients with ATC. Material and Methods. We analyzed the data on 150 patients diagnosed with ATC in the period from 1995 to 2006. The Kaplan-Meier method and log-rank test were used to determine overall survival. Prognostic factors were identified by univariate and multivariate Cox regression analysis. Results. The youngest patient was 35 years old and the oldest was 89 years old. According to univariate regression analysis, age was significantly associated with longer survival in patients with ATC. In multivariate regression analysis, patients age, presence of longstanding goiter, whether surgical treatment is carried out or not, type of surgery, tumor multicentricity, presence of distant metastases, histologically proven preexistent papillary carcinoma, radioiodine therapy, and postoperative radiotherapy were included. According to multivariate analysis, besides surgery (P = 0.000, OR = 0.43, 95% CI = 0.29–0.63), only patients age (P = 0.023, OR = 0.68, 95% CI = 0.49–0.95) was independent prognostic factor of favorable survival in patients with ATC. Conclusion. Age is a factor that was independently associated with survival time in ATC. Anaplastic thyroid cancer has the best prognosis in patients younger than 50 years.

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Anaplastic Thyroid Carcinoma in a Young Woman: A Rare Case of Survival

Cited by 20 publications

References 32 publications

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

Dyspnea as a prognostic factor in anaplastic thyroid carcinoma

Age as a Prognostic Factor in Anaplastic Thyroid Cancer

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