Anaplastic myxopapillary ependymoma of the sacrum: A case report

Abstract

Background: Myxopapillary ependymoma (MPE) with anaplastic features is extremely rare. There are very few such case reports in the medical literature. Case Description: A 23-year-old female presented with lower back pain, and both urinary and fecal dysfunction. The patient underwent gross total surgical excision of the MR documented expansile intrasacral tumor. The histology was compatible with a MPE containing anaplastic features. Conclusion: The medical literature contains a few comparable cases of subcutaneous sacrococcygeal MPE with anaplastic components. Here, however, we have a young female with an anaplastic intrasacral MPE treated with gross total surgical excision.

Myxopapillary Ependymoma Metastasis Mimicking Pulmonary Embolism: An Illustrative Case

“…Resection remains the gold standard treatment of MPEs. 6 7 However, treatment for metastatic MPEs is not standardized nationwide. Chemotherapy, radiation, and in one instance immunotherapy after initial resection of the primary lesion have been used previously.…”

“…5 Many studies demonstrate that adjuvant radiotherapy following resection is associated with increased progression-free survival (PFS). [6][7][8] However, other studies do not report significant differences in 5-year PFS, recurrence rate, or overall survival benefit with adjunctive radiotherapy or chemotherapy compared with surgical resection alone. 5,[7][8][9] In addition, MPEs rarely metastasize outside of the cerebrospinal axis, and pediatric patients show higher rates of central nervous system dissemination and extramedullary presentation than adults.…”

“…[6][7][8] However, other studies do not report significant differences in 5-year PFS, recurrence rate, or overall survival benefit with adjunctive radiotherapy or chemotherapy compared with surgical resection alone. 5,[7][8][9] In addition, MPEs rarely metastasize outside of the cerebrospinal axis, and pediatric patients show higher rates of central nervous system dissemination and extramedullary presentation than adults. 1,[10][11][12] A few published cases that show MPEs spread outside the neuroaxis into other organ systems, most commonly to the lymphatic system.…”

“…5 Many studies demonstrate that adjuvant radiotherapy following resection is associated with increased progression-free survival (PFS). 6 7 8 However, other studies do not report significant differences in 5-year PFS, recurrence rate, or overall survival benefit with adjunctive radiotherapy or chemotherapy compared with surgical resection alone. 5 7 8 9…”

“…6 7 8 However, other studies do not report significant differences in 5-year PFS, recurrence rate, or overall survival benefit with adjunctive radiotherapy or chemotherapy compared with surgical resection alone. 5 7 8 9…”