Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet's disease: A case report and review of literature

Luo, Jianxi; Jiang, Ying-Han; Lei, Zi; Miao, Yi

doi:10.12998/wjcc.v7.i20.3377

Cited by 3 publications

(3 citation statements)

References 20 publications

(29 reference statements)

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“…Cutaneous manifestations of ALCL have been noted in the literature to mimic dermatologic conditions such as eczema, pyoderma gangrenosum, and squamous cell carcinoma [ 17 ]. Luo et al [ 2 ] reported a case of ALK-negative ALCL presenting as Behcet's disease, with recurrent penile and oral ulcers initially treated with steroids without improvement and later diagnosed 4 weeks later with penile tissue biopsy. Oliveira et al [ 3 ] described a case of pcALCL presenting as a large pyogenic granuloma mimicking skin infection.…”

Section: Discussionmentioning

confidence: 99%

“…ALCL is a malignancy of CD30-positive T lymphocytes with distinct immunophenotypic characteristics. The 2016 revision of the World Health Organization classification of lymphoid neoplasms classifies ALCL into four categories: primary cutaneous, systemic anaplastic lymphoma kinase (ALK) positive, systemic ALK-negative, and breast implant-associated ALCL [ 2 ]. Primary cutaneous ALCL (pcALCL) has an indolent course with a 5-year survival rate of up to 96% [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Anaplastic Large Cell Lymphoma Presenting as Ulcerative Facial Mass: A Case Report

Knauss¹,

Glosser²,

Beran³

et al. 2022

Case Rep Oncol

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Anaplastic large cell lymphoma (ALCL) is a rare form of non-Hodgkin lymphoma (NHL) that can be aggressive with rapid speed, thus mandating a timely diagnosis to optimize treatment and deter progression. NHL classically presents with lymphadenopathy and constitutional symptoms. However, ALCL can present with nonspecific cutaneous manifestations with minimal or absent constitutional symptoms. The cutaneous involvement may resemble common dermatologic conditions, delaying diagnosis. We present a case of an aggressive cutaneous ALCL lesion mimicking facial cellulitis that rapidly progressed from a small comedone to a large, exophytic mass over the course of 1 month. Prior to presentation at our institution, the patient was previously diagnosed and treated for suspected bacterial infection with no response to therapy. Core needle biopsy of the forehead lesion confirmed the diagnosis of anaplastic lymphoma kinase-negative ALCL. Chemotherapy with brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone was planned for a total of 6–8 cycles with curative intent. By cycle 5, positron emission tomography and computed tomography demonstrated response to therapy with no enlarged or metabolically active lymph nodes appreciated. Our case report highlights the importance of developing a broad differential diagnosis for ulcerative facial masses, particularly when unresponsive to antimicrobial therapies. Lymphomas should be included in the differential diagnosis of patients with rapidly growing facial lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anaplastic Large Cell Lymphoma Presenting as Ulcerative Facial Mass: A Case Report

Knauss¹,

Glosser²,

Beran³

et al. 2022

Case Rep Oncol

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show abstract

“…Anaplastic large cell lymphoma (ALCL) is a rare CD30-positive T-cell non-Hodgkin lymphoma. The 2017 World Health Organization classification, which is the most recent classification, categorizes ALCL into anaplastic lymphoma kinase (ALK)-positive ALCL and ALK-negative ALCL [ 1 ]. The extranodal involvement of ALCL is rarer in the gastrointestinal tract than in the bones and bone marrow [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Successful treatment of post chemotherapy esophageal cicatricial atresia in a pediatric patient with anaplastic large cell lymphoma through minimally invasive esophagectomy: a case report

et al. 2021

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Background Anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell lymphoma, which is a rare type of non-Hodgkin lymphoma. ALCL rarely presents in the gastrointestinal tract, and the esophageal involvement in of ALCL is extremely rare. Case presentation An 11-year-old boy who complained of abdominal pain and cough was diagnosed with ALK-positive ALCL on the basis of systemic lymphadenopathy findings and immunohistochemistry results of pleural effusion. Although remission was observed after chemotherapy at 5 months after diagnosis, dysphagia persisted, and esophagoscopy revealed a severe stricture in the middle thoracic esophagus. At 9 months after diagnosis, allogeneic bone marrow transplantation was performed to ensure that complete remission was maintained; however, dysphagia and saliva retention did not improve. Approximately 10 months after diagnosis, esophagoscopy revealed a blind end in the middle thoracic esophagus, similar to that in congenital esophageal atresia. Subsequently, we performed minimally invasive subtotal esophagectomy under thoracoscopy and laparoscopy and gastric conduit reconstruction via the retrosternal route more than 2 years after allogeneic bone marrow transplantation. The final pathological diagnosis was esophageal atresia with esophagitis, with no malignancy. During postoperative evaluation, the patient required swallowing training for a few months, although no major complications were noted. Oral intake was possible, and complete remission was maintained at 14 month post-surgery. Conclusions Oncologists must consider the possibility of acquired esophageal cicatricial atresia as a complication during chemotherapy for ALCL. If esophageal obstruction or esophageal atresia occur and if remission is maintained, esophagectomy and esophageal reconstruction are useful treatment options for maintaining oral intake.

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Rapidly progressing primary pulmonary lymphoma masquerading as lung infectious disease: A case report and review of the literature

Jiang¹,

Zhang²,

Wu³

et al. 2021

WJCC

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BACKGROUND Primary anaplastic large cell lymphoma of the lung represents a diagnostic challenge due to diverse manifestations and non-specific radiological findings, particularly in cases that lack extra-pulmonary manifestations and lung biopsy. CASE SUMMARY A 40-year-old woman presented with a 6-d history of fever, dry coughing, and dyspnea. Her white blood cell count was 20100/mm 3 with 90% neutrophils. PaO 2 was 60 mmHg and SaO 2 was 90% when breathing ambient air. Chest computed tomography (CT) identified a solid nodule, 15 mm in diameter, with a poorly defined boundary in the upper right lung, and several smaller solid nodules throughout both lungs. Pulmonary artery CT and subsequent bedside X-ray showed diffuse patchy shadows throughout both lungs. Repeated cultures of blood samples and alveolar lavage failed to identify any pathogen. Due to the mismatch between clinical and imaging features, we conducted a bone marrow biopsy, and the results showed proliferation along all three lineages but no atypical or malignant cells. The patient received empirical antibacterial, antiviral, and antifungal treatments, as well as corticosteroids. The patient’s condition deteriorated rapidly despite treatment. The patient died 6 d after hospitalization due to respiratory failure. Post-mortem lung biopsy failed to show inflammation but identified widespread infiltration of alveolar septum by anaplastic lymphoma kinase (ALK)-positive anaplastic cells. CONCLUSION ALK-positive anaplastic large cell lymphoma could present as a primary pulmonary disease without extra-pulmonary manifestations.

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Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet's disease: A case report and review of literature

Cited by 3 publications

References 20 publications

Anaplastic Large Cell Lymphoma Presenting as Ulcerative Facial Mass: A Case Report

Anaplastic Large Cell Lymphoma Presenting as Ulcerative Facial Mass: A Case Report

Successful treatment of post chemotherapy esophageal cicatricial atresia in a pediatric patient with anaplastic large cell lymphoma through minimally invasive esophagectomy: a case report

Rapidly progressing primary pulmonary lymphoma masquerading as lung infectious disease: A case report and review of the literature

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