Anaplastic Large Cell Lymphomas: A Study of 75 Pediatric Patients

dʼAmore, Emanuele S.G.; Menin, Andrea; Bonoldi, Emanuela; Bevilacqua, P.; Donofrio, Vittoria; Gambini, Claudio; Forni, Marco; Gentile, A; Boldrini, R.; Magro, Gaetano; Pillon, Marta; Rosolen, Angelo; Stefania, Cazzavillan; Alaggio, Rita

doi:10.2350/06-04-0082

Cited by 8 publications

(13 citation statements)

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“…[18] A recent study of 75 cases of pediatric ALCLs from Italy revealed an ALK positivity in 90.7% of ALCL cases. [35] In our series the ALK positivity was seen in 81.5% of ALCL cases.…”

Section: Discussionsupporting

confidence: 50%

Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India

et al. 2011

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“…[18] A recent study of 75 cases of pediatric ALCLs from Italy revealed an ALK positivity in 90.7% of ALCL cases. [35] In our series the ALK positivity was seen in 81.5% of ALCL cases.…”

Section: Discussionsupporting

confidence: 50%

Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India

et al. 2011

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“…5,6 ALCL represents approximately 10%-15% of pediatric/adolescent non-Hodgkin lymphomas, as compared to 2% of adult non-Hodgkin lymphomas and 30%-40% of pediatric large cell lymphomas. The median age at diagnosis for pediatric patients is approximately 10.2-11.0 years, [7][8][9] and systemic ALCL rarely occurs in infants. [9][10][11][12] Most patients with ALKnegative ALCL are adults (age range, 40-65 years), with a slight male predominance.…”

Section: Discussionmentioning

confidence: 99%

A Primary Systemic ALCL Present Initially as Cutaneous Localized Skin Lesions

Alsayyah

Alhumidi

2015

The American Journal of Dermatopathology

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Anaplastic large cell lymphoma (ALCL) is classified into systemic and primary cutaneous subtypes. A primary systemic ALCL present initially as cutaneous localized skin lesions is a rare presentation. We present an unusual case of a 13-year-old boy with systemic ALCL who presented with cutaneous nodules. The systemic nature of this lymphoma was confirmed by immunohistochemical positivity of anaplastic lymphoma kinase and epithelial membrane antigen. Confirmation of this diagnosis will lead to a poorer prognosis and more aggressive systemic therapy.

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“…The difficulties in assessing the immunophenotype might be one important reason why immunophenotypic markers predicting the outcome of ALCL could not be detected in large series. 11,[15][16][17][18] Flow-cytometric immunophenotyping has only been performed on a very limited number of samples not taking the morphological subtype into account. 19,20 To overcome these limitations we performed immunofluorescence multi-staining combining antibodies for ALK to specifically identify lymphoma cells with antibodies directed against CD30, CD3, CD5, CD8, Ki67, CD56 and phosphorylated STAT3 (pSTAT3).…”

Section: Introductionmentioning

confidence: 99%

Expression of CD8 is associated with non-common type morphology and outcome in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

et al. 2013

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Anaplastic lymphoma kinase-positive anaplastic large T-cell lymphoma is characterized by morphological variability. Morphological variants (non-common subtype) are associated with a poor outcome. They display abundant reactive bystander cells admixed with the lymphoma cells. So far, the difficulty in distinguishing lymphoma cells from bystander cells by visual inspection has prevented detailed and reliable immunophenotypic analysis using conventional immunohistochemistry. To overcome these limitations, we analyzed 124 cases of pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma treated within clinical trials using immunofluorescence multi-staining and digital image analysis combining antibodies against anaplastic lymphoma kinase to specifically identify lymphoma cells with antibodies against CD30, CD3, CD5, CD8, Ki67 and phosphorylated STAT3. Non-common type anaplastic lymphoma kinase-positive anaplastic large cell lymphomas express CD8 more frequently than common type anaplastic lymphoma kinase-positive anaplastic large cell lymphomas (35.4% and 5.6%, respectively; P=0.0002). CD8 expression was associated with a poorer outcome. Importantly, in a multivariate analysis including clinical risk factors, histological subtype and CD8 expression, CD8-positivity proved to be an independent prognostic predictor of worse outcome (hazard ratio for survival 3.38, P=0.042).

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Anaplastic Large Cell Lymphomas: A Study of 75 Pediatric Patients

Cited by 8 publications

References 0 publications

Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India

Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India

A Primary Systemic ALCL Present Initially as Cutaneous Localized Skin Lesions

Expression of CD8 is associated with non-common type morphology and outcome in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

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