Anaplastic large cell lymphoma with primary involvement of the skeletal muscle: A case report

Yang, Zongyou; Liu, Yueju; Guo, Fang; Chen, Wei; Yin, Yingchao; Chen, Zhaoyu; Li, Han; Luo, Yang; Zhang, Yingze

doi:10.3892/ol.2015.3087

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The diagnosis of the present case was established on the biopsy tissue after careful exclusion of the morphological mimickers. Had there been material available for cell block preparation, a diagnosis might have been reached using the immunocytochemical studies 8. Rhabdomyosarcomas, the most common sarcoma in children and adolescents, show monomorphic round and occasional spindle cell morphology with evidence of myogenesis.…”

Section: Discussionmentioning

confidence: 99%

ALK-positive anaplastic large cell lymphoma of skeletal muscle masquerading as soft tissue sarcoma

et al. 2022

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Anaplastic large cell lymphoma (ALCL) is a subtype of T cell non-Hodgkin’s lymphoma and can present as an extranodal disease. Primary ALCL of skeletal muscle is rare. We report a case of ALK-positive ALCL involving the left thigh and anterior chest wall in a 12-year-old male child. The fine needle aspiration cytology from the lesion showed cellular smears with singly scattered and occasional clusters of large pleomorphic atypical cells. A diagnosis of poorly differentiated malignant neoplasm was rendered. On core biopsy, the histomorphological features posed a diagnostic challenge with a myriad of morphological mimickers. The diagnosis was established by excluding specific entities by relevant immunostains and confirming the diagnosis by strong expression of CD30 and ALK on immunohistochemistry. Fluorescence in-situ hybridisation confirmed the characteristic t(2:5) translocation. Presentation of ALCL with skeletal muscle involvement is uncommon, and the diagnosis relies on broadening the diagnostic possibilities and judicious use of immunohistochemical markers.

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Section: Discussionmentioning

confidence: 99%

ALK-positive anaplastic large cell lymphoma of skeletal muscle masquerading as soft tissue sarcoma

et al. 2022

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“…Some reporters have reported cases of ALK− ALCL with extranodal involvement of the skeletal muscles. [ 5 , 11 , 12 ]…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin lymphoma of multiple extranodal involvement seen on MRI, FDG PET–CT scans

Wang

Meng²,

Wang³

et al. 2017

Medicine

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Rationale:Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma (NHL). The most common extranodal sites of ALCL are skin, subcutaneous tissue, bone, lung, and gastrointestinal organs. This study reports a case of ALCL with multiple extranodal involvement, especially the whole body skeletal muscles, with the aim to share the imaging features of the ALCL including magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT).Patient concerns:A 54-year-old female patient presented with two-month history of bilateral shoulder pain, which had exacerbated for 6 days prior to admission. MRI scans revealed multiple hyperintense on T2-weighted image (T2WI) and marked inhomogenous diffuse or rim enhancement masses in shoulder muscles. The probable diagnoses must include metastatic carcinoma in the skeletal muscle, purulent abscess, soft-tissue sarcoma and lymphoma. For our patient, however, she did not have a history of cancer or hyperleukocytosis. 18F-FDG PET-CT was made for further evaluation and identified whether there is another related lesion. PET-CT image showed widespread FDG uptake lesions, including cervical/retroperitoneal lymphnodes, subcutaneous tissue, hepar and multiple groups of whole body muscles.Diagnoses:An ultrasound-guided tissue biopsy was performed on the left cervical lymphnodes. Histological and immunohistochemical examination showed ALK- ALCL.Interventions:Clinicians planned to give our patient systemic chemotherapy.Outcomes:Our patient died of multiple organ failure four weeks after her first visit to our hospital.Lessons:This disease should be considered when patient presented diffuse muscle swelling in particular when a history of cancer and hyperleukocytosis was not supported. The presence of soft tissue masses in skeletal muscles on MRI scans, as well as multiple marked focal tracer uptake on PET-CT and immunohistochemical analysis of the mass, may help the recognition of ALCL and the state of illness evaluation, allowing for the appropriate treatment strategy to be initiated.

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“…ALK positive ALCL represents approximately 3% of adult non-Hodgkin’s lymphomas and 10%-15% of childhood lymphomas[ 2 ]. ALCL mostly affects lymph nodes, while the involvement of extranodal sites, including the soft tissue, bone, lung, and liver, is uncommon[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of the literature

Zheng¹,

Yin²,

Hui³

et al. 2021

WJCC

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BACKGROUND Primary bone lymphoma (PBL) is an uncommon extranodal disease that represents approximately 1%-3% of lymphomas. Anaplastic lymphoma kinase (ALK) positive anaplastic large-cell lymphoma (ALCL) is an extremely rare type of PBL. The aim of this report is describe the symptoms, diagnosis, and treatment of primary bone ALK-positive ALCL. CASE SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 mo. After extensive evaluation, positron emission tomography-computed tomography (CT) examination showed multiple osteolytic bone lesions without other sites lesions. CT-guided biopsy of the T10 vertebral body was performed, and the pathology results showed that neoplastic cells were positive for ALK-1, CD30, and CD3. A diagnosis of primary bone ALK positive ALCL was ultimately made. The patient was in partial response after four cycle soft cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy, and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of therapy. CONCLUSION Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement, and lymphoma should be considered in the differential diagnosis of primary bone lesions.

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Anaplastic large cell lymphoma with primary involvement of the skeletal muscle: A case report

Cited by 4 publications

References 23 publications

ALK-positive anaplastic large cell lymphoma of skeletal muscle masquerading as soft tissue sarcoma

ALK-positive anaplastic large cell lymphoma of skeletal muscle masquerading as soft tissue sarcoma

Non-Hodgkin lymphoma of multiple extranodal involvement seen on MRI, FDG PET–CT scans

Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of the literature

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