Anaplastic large cell lymphoma with axial skeletal lesions portends a poor prognosis

Al-Asaadi, Zahra; Sammour, Fatin; Patel, Ketan; Chetty, Naren; Dubrey, Simon W

doi:10.12968/hmed.2015.76.10.606

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Considering the limitations of the treatment strategy, our patient was mobilized with stem cells before radiotherapy, and enough stem cells were collected as an alternative treatment. Unlike in conventional nodular ALCL, the significance of ALK + in patients with primary bone ALCL has not been clearly determined ( 5 , 6 ).…”

Section: Discussionmentioning

confidence: 99%

Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with primary bone involvement: a case report

Cheng,

Huang,

Chen

et al. 2024

AME Case Rep

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Background Lymphomas originating in bone but not involving visceral or regional lymph nodes are diagnosed as primary bone lymphoma (PBL). Few case reports of anaplastic large-cell lymphoma (ALCL) originating in bone have been reported. The purpose of this report is to describe the difficulty in diagnosing and complete treatment process of this rare type of bone lymphoma. Case Description We describe a case of anaplastic lymphoma kinase positive (ALK + ) ALCL patient with primary multiple bone lesions. The patient was initially in the local hospital due to lumbosacral pain and was diagnosed with multiple myeloma. However, after receiving two cycles of bortezomib, lenalidomide and dexamethasone (VRD) chemotherapy, the patient’s pain increased. After discussion with the patient and his family, the patient finally agreed to accept the biopsy of the T10 and L2 vertebral bodies and diagnosed as ALK + ALCL stage IV with primary bone involvement. After receiving multiple cycles of chemotherapy, local bone radiotherapy and denosumab treatment, the patient’s bone pain and osteolytic lesions were improved. Regular follow-up shows that the patient’s bone pain has been controlled and he is generally in good condition. Conclusions ALK + ALCL originating primarily in the bone may be easily misdiagnosed and hence require appropriate evaluation in the upfront setting. In consideration of the lack of relevant experience due to the rarity of the disease, choosing a suitable treatment regimen requires comprehensive consideration. In the next clinical work, we must observe relevant cases to summarize the treatment experience better.

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Section: Discussionmentioning

confidence: 99%

Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with primary bone involvement: a case report

Cheng,

Huang,

Chen

et al. 2024

AME Case Rep

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“…In patients with knee prosthesis lymphomas are rare, and among ALCL cases only ALK-negative variants have been documented [ 5 ]. Among bony ALCL cases, common sites include the iliac bones [ 6 ], the sternum [ 7 ], the proximal femur [ 8 ], vertebrae, and ribs [ 9 , 10 , 11 ]. Primary non-Hodgkin’s lymphoma of the knee joint has also been reported, and in rare cases, it has been found to involve the synovium [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Anaplastic Large Cell Lymphoma of the Knee Joint

Zade,

Rao,

Patil

et al. 2023

JOCR

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Introduction: Anaplastic large cell lymphoma (ALCL), which makes up only 2–5% of instances of NHL, is a rare and aggressive form of the disease. Anaplastic Lymphoma Kinase (ALK)-positive ALCL is a variant of the illness that is identified by the presence of an ALK gene fusion. The disease is most commonly confined to the nodes, but extranodal spread has been reported. Skin and soft tissue are the most frequently identified locations for extranodal involvement, while joints are extremely rare. We describe a rare case of ALCL affecting the knee joint that is ALK -positive. Case Report: A 51-year-old female presented with pain in her right knee. It was diagnosed as synovitis and treated accordingly. The symptoms did not relieve and a magnetic resonance imaging (MRI) scan was performed that indicated a meniscus tear. She was treated for it; however, the symptoms worsened. She underwent two more scans (1 MRI and 1 PET) that indicated an enhancing polypoidal mass in the knee joint, and two arthroscopic procedures. The histopathology report indicated an ALK-positive ALCL. She was treated with Brentuximab vedotin + CHP followed by involved-site radiotherapy to the postoperative region with margins. The patient has had a complete clinical and pathological response which was assessed after 1 year from the start of the treatment. Conclusion: This is the first instance of primary ALK-positive ALCL affecting the knee joint that has been documented, to the best of our knowledge. The case emphasizes the significance of taking ALCL into account when determining the differential diagnosis of knee joint tumors as well as the requirement for a thorough assessment of extranodal involvement. Keywords: Lymphoma, knee joint, ALCL, extranodal lymphoma, ISRT, chemotherapy, arthroscopic surgery.

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Anaplastic large cell lymphoma with axial skeletal lesions portends a poor prognosis

Cited by 2 publications

References 7 publications

Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with primary bone involvement: a case report

Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with primary bone involvement: a case report

A Rare Case of Anaplastic Large Cell Lymphoma of the Knee Joint

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