Anaplastic ductal carcinoma of the pancreas with more than 10-year postoperative survival. Report of 3 cases

Saegusa, Shotaro; Sekoguchi, Tsutomu; Kuriyama, Naohisa; Ido, Masayoshi; Ito, Fumito; Yamazaki, Yoshio

doi:10.2958/suizo.20.46

Cited by 30 publications

(1 citation statement)

References 3 publications

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“…The clinical outcome of anaplastic carcinoma of the pancreas is abysmal after surgical resection [21]. However, some authors have reported a rare case of long survival after surgery and a case that responded well to chemotherapy or radiotherapy [22,23]. We treated the patient with gemcitabine as adjuvant chemotherapy and with radiotherapy for the local recurrence.…”

Section: Discussionmentioning

confidence: 97%

A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor

Murata

Tomita

Sakaguchi

et al. 2009

Clin J Gastroenterol

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We report a case of anaplastic carcinoma of the pancreas with production of granulocyte-colony stimulating factor (G-CSF) in a 59-year-old male. He was referred to our hospital with a chief complaint of epigastralgia and suffered from leukocytosis. Differential diagnosis included pancreatic tumors and submucosal tumor of the stomach, but definite preoperative diagnosis could not be made. He underwent distal pancreactomy, total gastrectomy with Roux-en-Y reconstruction and splenectomy. He recovered uneventfully postoperatively and was discharged from hospital on the 14th postoperative day. Histological examination showed anaplastic carcinoma of the pancreas. Since the peripheral leukocyte count was sharply decreased after the operation, we suspected the tumor would be producing G-CSF. Then immunohistochemistry showed a positive stain in the tumor. Therefore, we diagnosed the tumor as anaplastic carcinoma of the pancreas producing G-CSF. Three months after the resection, local recurrence was detected by abdominal computed tomography. The patient died of hemorrhagic shock due to tumor invasion of the intestine 8 months after the operation.

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Section: Discussionmentioning

confidence: 97%

A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor

Murata

Tomita

Sakaguchi

et al. 2009

Clin J Gastroenterol

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A Case of Giant Cell Type Anaplastic Carcinoma of the Pancreas With Hemosuccus Pancreaticus

Mizukami¹,

Sasada²,

Hashida³

et al. 2008

Pancreas

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A Case of Pleomorphic Carcinoma of the Pancreas

Suzuki¹,

Harada²,

Suzuki³

et al. 2008

Pancreas

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Vol 22, No 2, pp 110Y116. It is generally accepted that disorder of coagulation-fibrinolysis system occurs in acute pancreatitis. 1 Patients presenting coagulative abnormalities on admission have high incidence of DIC, MODS and poor prognosis. 2,3 This study aimed to investigate the disorder of coagulation-fibrinolysis system in patients with severe acute pancreatitis (SAP). Diagnosis and evaluation of the severity of acute pancreatitis were made according to the Japanese criteria (Japanese severity score; JSS). In the criteria, SAP is defined as JSSQ2. The subjects were 145 patients with SAP in our department between 1990 and 2006. On admission, aberrant rates of platelet count, prothrombin timeinternational normalized ratio (PT-INR), antithrombin III, thrombin-antithrombin III complex (TAT), activated protein C, fibrin/fibrinogen degradation products, D-dimer, plasminogen activator inhibitor-1, and thrombomodulin were 34%, 32%, 41%, 100%, 91%, 78%, 100%, 58%, 58%, respectively, and those of TAT and D-dimer were very high. PT-INR (R = 0.404), TAT (R = 0.392), and platelet count (R = j0.196) had significant correlation with JSS. TAT concentration on admission was higher in patients of Stage 3&4 (9e JSSe 27) (33 T 14 ng/ml) than Stage 2 (2e JSSe 8) (22 T 4 ng/ml). PT-INR and TAT in non-survivors (1.4 T 0.1 and 43 T 17 ng/ml) were significantly higher than those in survivors (1.1 T 0.0 and 19 T 4 ng/ml). Mortality rate in patients with PT-INRQ1.15 on admission (41%) was significantly higher than that in patients with PT-INRG1.15 on admission (16%). Mortality rate in patients with TATQ45 ng/ml on admission (75%) was significantly higher than that in patients with TATG45ng/ml on admission (17%) (Fig. 1). These results suggest that TAT may be a useful marker for severity and prognosis in SAP. Particularly in patients with TATQ45 ng/ml on admission, intensive care should be performed in a highly specialized institution.JPS SELECTED ABSTRACT 1 FIGURE 1. A: ROC curve of TAT for predicting death in severe acute pancreatitis. B: Prediction of mortality by TAT on admission.luminal LCRF content 4-h after BPJD was significantly lower in rats treated with TI than in controls. The hypertrophied pancreas may require a smaller dose of CCK to increase protein secretion.

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Anaplastic ductal carcinoma of the pancreas with more than 10-year postoperative survival. Report of 3 cases

Cited by 30 publications

References 3 publications

A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor

A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor

A Case of Giant Cell Type Anaplastic Carcinoma of the Pancreas With Hemosuccus Pancreaticus

A Case of Pleomorphic Carcinoma of the Pancreas

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