Anaplastic Carcinoma of the Pancreas: Clinical and Morphological Characteristics

Подзолков, В. И.; Pokrovskaya, A. E.; Vargina, T. S.; Ponomarev, A. B.; Kogan, Yevgenia A.; Lerner, J V

doi:10.1159/000511037

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…The stroma is biologically highly active and significantly influences tumor growth, metastatic spread, and resistance to therapy [ 4 ]. Therefore, it is likely that CAFs influence the biology of PDAC through several mechanisms [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma

Mandys

Popov

Gürlich

et al. 2023

IJMS

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Therapy for pancreatic ductal adenocarcinoma remains challenging, and the chances of a complete cure are very limited. As in other types of cancer, the expression and role of miRNAs in controlling the biological properties of this type of tumor have been extensively studied. A better insight into miRNA biology seems critical to refining diagnostics and improving their therapeutic potential. In this study, we focused on the expression of miR-21, -96, -196a, -210, and -217 in normal fibroblasts, cancer-associated fibroblasts prepared from a ductal adenocarcinoma of the pancreas, and pancreatic carcinoma cell lines. We compared these data with miRNAs in homogenates of paraffin-embedded sections from normal pancreatic tissues. In cancer-associated fibroblasts and cancer cell lines, miRNAs differed significantly from the normal tissue. In detail, miR-21 and -210 were significantly upregulated, while miR-217 was downregulated. Similar transcription profiles were earlier reported in cancer-associated fibroblasts exposed to hypoxia. However, the cells in our study were cultured under normoxic conditions. We also noted a relation to IL-6 production. In conclusion, cultured cancer-associated fibroblasts and carcinoma cells reflect miR-21 and -210 expression similarly to the cancer tissue samples harvested from the patients.

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Section: Introductionmentioning

confidence: 99%

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma

Mandys

Popov

Gürlich

et al. 2023

IJMS

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A case of anaplastic carcinoma of the pancreas with intrasplenic huge mass formation

Miyata

Nishiki

Shinden

et al. 2023

Journal of Surgical Case Reports

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Anaplastic carcinoma of the pancreas (ACP) is an aggressive pancreatic tumor that grows rapidly, and its clinical characteristics are poorly defined because of its rarity. Thus, preoperative diagnosis is difficult and most definitive diagnoses are generally made by surgery, highlighting the importance of collecting more cases of ACP. We report a case of a 79-year-old woman with ACP that was difficult to diagnose preoperatively. Abdominal enhanced computed tomography revealed a large and expansive tumor in the spleen containing multilocular cystic and solid components. The first preoperative diagnosis was splenic angiosarcoma, and the tumor could be resected by distal pancreatectomy, total gastrectomy and partial transverse colectomy. ACP was first diagnosed based on postoperative histopathological findings. ACP that spreads to the spleen and forms an intrasplenic mass is rare. However, ACP should be included in the differential diagnosis of such patients, and further research of ACP is essential for a favorable prognosis.

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Anaplastic Carcinoma of the Pancreas: Clinical and Morphological Characteristics

Cited by 2 publications

References 4 publications

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma

Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma

A case of anaplastic carcinoma of the pancreas with intrasplenic huge mass formation

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