Anaplastic astroblastoma: a rare glial tumour

Binesh, Fariba; Akhavan, Ali; Navabii, Hossein; Mehrabaniyan, Mohammadreza

doi:10.1136/bcr.06.2011.4323

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…A bimodal distribution is commonly observed, with the majority of reported cases occurring in patients between 10 to 30 years of age. [4] This is in contrast to glioblastoma multiforme (GBM), meningioma, and oligodendroglioma, which affect older adults, while ependymoma and atypical teratoid rhabdoid tumor (ATRT) are often found in younger children. There is also a female predominance among patients diagnosed with astroblastoma.…”

Section: Discussionmentioning

confidence: 99%

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

Samples¹,

Henry²,

Bazán³

et al. 2016

Surg Neurol Int

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Background:Astroblastoma is a rare neuroepithelial tumor that often originates in the cerebral hemisphere of children and young adults. Diagnosis of this obscure neoplasm can be difficult because these tumors are so infrequently encountered and share common radiological and neuropathological features of other glial neoplasms. As such, it should be included in the differential diagnosis of astrocytoma and ependymoma if the clinical and radiographic features suggest it. Standardized treatment of astroblastomas remains under dispute because of the lack of knowledge regarding the tumor and a paucity of studies in the literature.Case Description:We present a case of a low-grade astroblastoma diagnosed in a 30-year-old female with seizures, headache, and vision changes. She underwent gross total resection and, without evidence of high-grade features, adjuvant therapy was not planned postoperatively. Post-operative surveillance suggested early recurrence, warranting referral to radiation therapy. Patient ended up expiring despite adjuvant therapy secondary to extensive recurrence and tumor metastasis.Conclusions:Astroblastoma must be considered in the differential of supratentorial tumors in children and young adults. Treatment of such, as suggested by most recent literature, includes gross total resection and adjuvant radiotherapy for lesions exhibiting high-grade features.

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Section: Discussionmentioning

confidence: 99%

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

Samples¹,

Henry²,

Bazán³

et al. 2016

Surg Neurol Int

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“…Lack of peritumoral edema is not uncommon. Although astroblastoma in most circumstances shows the aforementioned features, it can be confused with other brain tumors, including neuroectodermal, ependymoma, and other gliomas [1]. Moreover, depending solely upon the morphological features does not allow for differentiation between high-or low-grade tumor, which necessitates a pathological diagnosis [1,6].…”

Section: Discussionmentioning

confidence: 99%

“…Astroblastoma pathological features include short processes forming perivascular pseudorosettes, vessel hyalinization, and a fibrillar pattern [1]. The differentiation between astroblastoma and nonglial tumors can be done by immunohistochemical features that show different degrees of positivity to S-100, vimentin, and GFAP [2,10,19].…”

Section: Discussionmentioning

confidence: 99%

“…The tumor progression was reported in many cases as unpredictable; however, well-differentiated forms are less infiltrative and show lower clinical progression in terms of symptoms and complications [1]. Some authors support the use of radiation in high-grade tumors to retard their aggressive behavior although the role of radiation is not yet well-defined in astroblastoma management [8,13,21].…”

Section: Discussionmentioning

confidence: 99%

“…Astroblastoma is a rare glial tumor of uncertain origin occurring in children and adults. However, it rarely emerges as a congenital lesion or among the elderly [1,2]. Astroblastoma makes up to 3% of all glioma types [2].…”

Section: Introductionmentioning

confidence: 99%

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Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature

Samkari¹,

Hmoud²,

Almehdar³

et al. 2015

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Astroblastoma is a rare brain tumor occurring in children and adults, rarely in the elderly. It constitutes up to 3% of all brain tumors. We report a case of a 14-year-old girl who presented with recurrent seizures and minimal right hemiparesis. Magnetic resonance imaging (MRI) revealed a left fronto-parietal brain tumor. It was managed with subtotal resection in a local hospital. Subsequently, she was referred to Princess Nora Oncology Center for further characterization and management. Pathology slide revision revealed well-differentiated astroblastoma. Upon follow up, the patient had multiple recurrences of the same tumor and emergence of a new lesion at the area of Sylvian fissure. Excision of the emerging tumor revealed anaplastic astroblastoma. Astroblastoma is a glial tumor that predominantly affects females. Its clinical progression is unpredictable, with high recurrence rate. Surgical intervention is considered the mainstay of treatment, while radiotherapy and chemotherapy effectiveness is debatable. To our knowledge, this is the first reported case of well-differentiated and anaplastic astroblastoma as two separate neoplastic lesions in the same patient with its clinical, radiological, and pathological features.

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Astroblastoma

Mallick¹

2021

Evidence Based Practice in Neuro-Oncology

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Anaplastic astroblastoma: a rare glial tumour

Cited by 10 publications

References 22 publications

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature

Astroblastoma

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