Anaphylaxis with Latrodectus Antivenin Resulting in Cardiac Arrest

Murphy, Christine; Hong, Jeannie J.; Beuhler, Michael C.

doi:10.1007/s13181-011-0183-1

Cited by 31 publications

(18 citation statements)

References 34 publications

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“…Some Latrodectus venom includes proteinases and other potentially cyctotoxic components (Duan et al 2008). Latrodectus antivenom is effective against S. grossa venom -although potentially very dangerous as a treatment through anyphylaxis related to injection of sera (Graudins et al 2002;Isbister & Fan 2011;Murphy et al 2011;Garb & Hayashi 2013).…”

Section: Cytotoxicity Ulceration Necrotic Arachnidism and Putative Bacterial Carriagementioning

confidence: 99%

The 'Noble false widow' spider Steatoda nobilis is an emerging public health and ecological threat.

Hambler¹

2019

Preprint

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Steatoda nobilis, the 'Noble false widow' spider, has undergone massive population growth in southern Britain and Ireland, at least since 1990. It is greatly under-recorded in Britain and possibly globally. Now often the dominant spider on and in buildings in the region, the species occurs on many items which increase a risk of bites to people - including household furniture, railings, handles, lighting and street furniture. There is a lack of awareness amongst the public, medics and arachnologists as to the likely bite rate and severity with this spider, and there is under-recording of bites. There is thus a possibility of bites being left without adequate rapid treatment and monitoring - with a low but non-trivial risk of necrosis or sepsis. A plausible incident of anaphylactic shock is identified, requiring professional confirmation and case study. Further study of bite significance is urgently required but a typically precautionary approach should be adopted in the interim. A lag of over a century between introduction and the species rapidly becoming common in Britain indicates the risk of complacency over invasive species. Local eradication will be very difficult, so education is required on identification and response to possible bites. The species may become a widespread public health concern and a global conservation problem - particularly on islands with endemic invertebrates. Arachnologists typically have a conflict of interest which may result in understatement of risks. Research priorities include: assays for venom cytotoxicity and microbial carriage; improved immunological and clinical surveillance for possible spider bites; and monitoring of the global distribution and ecological impacts. This paper aims to facilitate and stimulate inter-disciplinary knowledge exchange and gathering, to enable more appropriate and proportionate responses to bites, infestations and invasions. Version 4 of this preprint has been peer-reviewed and recommended by Peer Community In Zoology (https://doi.org/10.24072/pci.zool.100001).

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Section: Cytotoxicity Ulceration Necrotic Arachnidism and Putative Bacterial Carriagementioning

confidence: 99%

The 'Noble false widow' spider Steatoda nobilis is an emerging public health and ecological threat.

Hambler¹

2019

Preprint

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“…There are several commercial antivenoms available, and the use of antivenom has been shown to decrease pain duration and severity such that discharge home is more likely [ 14 , 17 ]. Adverse events associated with the use of antivenom include anaphylaxis, serum sickness and rarely death [ 14 , 17 - 19 ]. As such, it is highly suggested that consultation with a clinical toxicologist or another widow bite expert is carried out.…”

Section: Discussionmentioning

confidence: 99%

A Case of Brown Widow Envenomation in Central Florida

Earwood

Ladde

Giordano

2020

Cureus

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Latrodectus geometricus, also known as the brown widow or brown button spider, is an unrenowned relative of the American black widow. While brown widow envenomation is generally thought of as mild, it does have the potential to lead to moderate or severe features similar to black widow bites. We report a case of brown widow envenomation that led to a moderate reaction including rash, local pain, pain radiating proximally in the extremity and nausea. Poison control was consulted for aid in spider identification. The patient was treated for pain control and muscle relaxation and monitored for eight hours. After proper tetanus prophylaxis, the patient was successfully discharged home with well-controlled, but continued mild symptoms. This case highlights a little-known, but clinically relevant species of widow spider with a wide distribution. Expeditious identification and treatment of brown widow bites can increase patient comfort, satisfaction, and discharge rates.

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“…11 Most reports show that BSW antivenin is well tolerated, particularly in the pediatric population. 5,6,14 In spite of these reports, antivenin is still considered to be safe and effective in rapidly relieving symptoms in cases of severe envenomation. In 1 Australian study using antivenin to the red black spider (Latrodectus hasselti), the incidence of serum sickness was 1% to 7%.…”

Section: Discussionmentioning

confidence: 99%

Recognition and Successful Treatment of Priapism and Suspected Black Widow Spider Bite With Antivenin

Goel¹,

Yabrodi²,

Fortenberry³

2014

Pediatric Emergency Care

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Priapism, although uncommon in preadolescent children, is considered a true emergency. Envenomation by a black widow spider bite has been reported to induce priapism as a manifestation of its toxicity. Early recognition and timely administration of antivenin have been reported to be effective in relieving priapism. Clinicians who care for children need to be aware of this unusual presentation. The diagnosis is traditionally from either direct observation of a spider bite or capture of a spider. We report a case of a previously healthy 2-year-old boy who presented with severe irritability, leg cramps, and stomach ache. The diagnosis of a likely black widow spider envenomation was made on the basis of clinical suspicion and suggestive physical findings in absence of demonstrated exposure. This case highlights the importance of early recognition and successful resolution of symptoms with administration of antivenin and supportive care.

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Anaphylaxis with Latrodectus Antivenin Resulting in Cardiac Arrest

Cited by 31 publications

References 34 publications

The 'Noble false widow' spider Steatoda nobilis is an emerging public health and ecological threat.

The 'Noble false widow' spider Steatoda nobilis is an emerging public health and ecological threat.

A Case of Brown Widow Envenomation in Central Florida

Recognition and Successful Treatment of Priapism and Suspected Black Widow Spider Bite With Antivenin

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